Search results for "Ridge"

Encapsulation of xenon by bridged resorcinarene cages with high 129Xe NMR chemical shift and efficient exchange dynamics

2023

Functionalized cages encapsulating xenon atoms enable highly sensitive, background-free molecular imaging through a technique known as HyperCEST 129Xe MRI. Here, we introduce a class of potential biosensor cage structures based on two resorcinarene macrocycles bridged either by aliphatic carbon chains or piperazines. First-principles-based modeling predicts a high chemical shift (about 345 ppm) outside the typical experimental observation window for 129Xe encapsulated by the aliphatically bridged cage and two 129Xe resonances for the piperazine-bridged cages corresponding to single and double loading. Based on the computational predictions as well as 129Xe chemical exchange saturation trans…

Bridges: A World Community for Mathematical Art

2016

Evolutionary plasticity of SH3 domain binding by Nef proteins of the HIV-1/SIVcpz lentiviral lineage

2021

ABSTRACTThe accessory protein Nef of human and simian immunodeficiency viruses (HIV and SIV) is an important pathogenicity factor known to interact with cellular protein kinases and other signaling proteins. A canonical SH3 domain binding motif in Nef is required for most of these interactions. For example, HIV-1 Nef activates the tyrosine kinase Hck by tightly binding to its SH3 domain. An archetypal contact between a negatively charged SH3 residue and a highly conserved arginine in Nef (Arg77) plays a key role here. Combining structural analyses with functional assays, we here show that Nef proteins have also developed a distinct structural strategy - termed the “R-clamp” - that favors th…

What grafting materials produce greater alveolar ridge preservation after tooth extraction? A systematic review and network meta-analysis

2021

Abstract A systematic review and network meta-analysis was conducted to compare different bone-substitute materials used for alveolar ridge preservation after tooth extraction. The electronic search was carried out on Embase, PubMed, Cochrane Library, Web of Science, Scopus, LILACS, and grey literature up to March 22, 2020 (registration number INPLASY202030005). Only randomized controlled trials were included to answer the following PICOS question: ‘What grafting materials produce greater alveolar ridge preservation after tooth extraction?’ The primary outcomes were the alveolar width resorption 1 mm below the alveolar crest and buccal height resorption in millimeters. Of the 4379 studies i…

Schlesien als Brücke - aber wohin? Vielfache Dimensionen einer äußerst beliebten Metapher

2020

Artykuł prezentuje różnorodne aspekty użycia metafory pomostu w odniesieniu do Śląska, ze szczególnym uwzględnieniem Górnego Śląska. Region ten jest przedstawiany metaforycznie jako pomost pomiędzy Polską a Niemcami oraz mieszkańcami obu krajów. Szczególna rola w tworzeniu tych więzi przypada mniejszości niemieckiej, która jest częstokroć określana jako pomost. Metafora ta jest rozszerzana o kolejne płaszczyzny znaczeniowe, jak np. pomost do Europy czy pomost między narodami. Autorka zauważa jednak, że Śląsk nie jest jedynym regionem pretendującym do bycia pomostem. Także inne europejskie miasta, regiony, jak i całe państwa chcą być postrzegane w tej roli.

THE REHABILITATION THROUGH EXTERNAL PRESTRESSING OF HISTORICAL REINFORCED CONCRETE BRIDGES WITH REDUCED PERFORMANCE: A CASE STUDY

2022

Many existing reinforced concrete bridges exhibit behaviour at the Service Limit State and the Ultimate Limit State which can be considered unsatisfactory with respect to the current provisions of Codes, but which are actually deficiencies deriving from obsolete calculation methods, structure age, material degradation, diffuse or localized corrosion and increased loads. Among these, cantilever bridges with half-joints may present a decrease in global safety coefficients for the most stressed current sections of the deck or in the local ones, that affect the performance of elements sensitive to degradation, such as Gerber saddles. In these cases, simple strengthening interventions through ex…

Ancient bridges of Sicily: punctual signs of a past that disappears

2018

Sono indelebili i segni lasciati dall’uomo sul territorio, testimonianze che il tempo conserva e la storia ci consegna e il cui insieme costituisce una trama fittissima che si sovrappone alla struttura fisica dell’ambiente, integrandolo e modificandolo. Grandi opere, monumenti universalmente riconosciuti come capolavori della mente e delle mani dell’uomo, ma anche opere minori, manufatti d’uso comune, beni isolati che costituiscono gli elementi puntuali di una più vasta e complessa organizzazione di fenomeni insediativi, le tessere di un mosaico ricco di sfumature e riflessi, frutto di un lungo processo di stratificazione storica. Alla categoria dei beni isolati appartengono le torri, i cas…

Rilievo e ricostruzione virtuale del Ponte Sud di Hierapolis di Frigia (Turchia)

2015

[ES] El artículo se refiere al levantamiento topográfico y la reconstrucción en 3D de un puente-acueducto romano situado inmediatamente al sur de Hierápolis, en Frigia (suroeste de Turquía), a lo largo del antiguo camino dirigido a Colosas, en el interior de Anatolia. Actualmente sólo se conservan su pilar sur y escasos restos del pilar norte. Se encuentra en una situación muy difícil, en el interior de un valle estrecho y profundo, y nunca se ha estudiado antes. Durante la campaña de trabajo de campo de 2011 de la Misión Arqueológica Italiana, fue examinado con un diferencial de alta precisión del sistema GPS (para la documentación del plan y su posicionamiento en el mapa digital arqueológ…

Dissection of keratin dynamics: different contributions of the actin and microtubule systems.

2005

It has only recently been recognized that intermediate filaments (IFs) and their assembly intermediates are highly motile cytoskeletal components with cell-type- and isotype-specific characteristics. To elucidate the cell-type-independent contribution of actin filaments and microtubules to these motile properties, fluorescent epithelial IF keratin polypeptides were introduced into non-epithelial, adrenal cortex-derived SW13 cells. Time-lapse fluorescence microscopy of stably transfected SW13 cell lines synthesizing fluorescent human keratin 8 and 18 chimeras HK8-CFP and HK18-YFP revealed extended filament networks that are entirely composed of transgene products and exhibit the same dynamic…

Adolphe Gubler y el <em>Journal de Thérapeutique</em> (1874-1883)

1993

El presente trabajo pretende ser un acercamiento a una de las revistas francesas de terapéutica que ejercieron mayor influencia en la medicina española del siglo XIX: el Journal de Thérapeutique. A pesar de que tuvo una pervivencia relativamente corta, desde 1874 a 1883, se publicó durante una de las etapas más importantes de la historia de la terapéutica y farmacología europeas, que se caracterizó ·por acercar a la realidad clínica los nuevos y revolucionarios avances de la farmacología experimental que había iniciado François Magendie con gran éxito. El alma de la publicación fue Adolphe Gubler, que influyó mucho sobre los principales cultivadores del arte de curar españoles del último cu…