Search results for "Rifa"
showing 10 items of 130 documents
Composition influence on pulmonary delivery of rifampicin liposomes.
2012
The effects of lipid concentration and composition on the physicochemical properties, aerosol performance and in vitro toxicity activity of several rifampicin-loaded liposomes were investigated. To this purpose, six liposome formulations containing different amounts of soy phosphatidylcholine and hydrogenated soy phosphatidylcholine, with and without cholesterol and oleic acid, were prepared and fully characterized. Uni- or oligo-lamellar, small (~100 nm), negatively charged (~60 mV) vesicles were obtained. Lipid composition affected aerosol delivery features of liposomal rifampicin; in particular, the highest phospholipid concentration led to a better packing of the vesic…
Gut Microbiota Cannot Compensate the Impact of (quasi) Aposymbiosis in Blattella germanica
2021
Simple Summary The German cockroach Blattella germanica is a good model to study complex symbiotic relationships because the following two symbiotic systems coexist in a single individual: the endosymbiont Blattabacterium (living inside specialized cells called bacteriocytes) and the gut microbiota. Although the role of the endosymbiont has been fully elucidated, the function of the gut microbiota remains unclear. The study of the gut microbiota will benefit from the availability of insects deprived of Blattabacterium. Our goal is to determine the effect of the removal (or, at least, the reduction) of the endosymbiont population on the cockroach’s fitness, in a normal gut microbiota communi…
Klinik und Therapie der fr�hen lepromat�sen Lepra an einem Fallbeispiel
1994
Taking into account the increase in worldwide human migration, leprosy is of growing importance in the differential diagnosis of dermatological diseases encountered in Central Europe. We report on the case of a young man from Ghana who developed hypopigmented maculae and plaques on his trunk and proximal limbs. The diagnosis of lepromatous leprosy could be made in consideration of the histological pattern of infiltrating leucocytes and detection of numerous acid-fast mycobacteria on skin biopsy. The results of the physical examination as well as routine laboratory and immunological parameters were consistent with this form of leprosy. Due to glucose-6-phosphate-dehydrogenase deficiency, tre…
Lymphadenitis colli durch nichttuberkulöse Mykobakterien (NTM) im Kindesalter - Eine Fallserie und Literaturübersicht
2003
Objective Lymphadenitis colli due to NTM should always be considered in children with cervical Lymphadenitis. For Germany there is a lack of data concerning the incidence, the epidemiology, the diversity and frequency of the different bacteria, the diagnosis, the clinical manifestation and the medical treatment. Methods By means of a questionnaire, which was retrospective for 1985 to 1994 and was sent to 277 children's hospitals in Germany, we collected data on Lymphadenitis colli in Germany. In our study we also incorporated cases from the "National Laboratory for Mycobacteria" in Borstel as well as six cases from our hospital in Mainz. Therefore our data includes both clinical (28) and la…
Quality of life as a therapeutic objective in the management of hepatic encephalopathy and the potential role of rifaximin-α
2021
Objective Quality of life (QoL) is impaired in patients with hepatic encephalopathy and rifaximin-α can improve QoL within 6 months. This study assessed the importance of QoL as a therapeutic objective in hepatic encephalopathy management; whether QoL is routinely assessed in hepatic encephalopathy patients in clinical practice and the role of rifaximin-α in this context. Methods A survey was conducted of healthcare professionals (HCPs) from Europe and Australia involved in hepatic encephalopathy management. HCPs rated the importance of a range of therapeutic objectives on a 1–7 Likert scale (1 = not at all important; 7 = extremely important). HCPs were also required to provide three patien…
Bakteriofāga izcelsmes dsRNS (Larifan) ietekme uz melanomas augšanu peļu audzēju modeļos
2020
Melanoma ir ļaundabīgs audzējs, kas veidojas galvenokārt ādā no tur esošajiem melanocītiem. Melanomai ir raksturīga strauja slimības gaita un agrīna metastazēšanās. Tā ir rezistenta pret standarta terapeitiskajām metodēm. Ievērojamais nesenais progress melanomas ārstēšanā arī nav devis gaidītos rezultātus, tāpēc joprojām tiek meklēti jauni melanomas ārstēšanas paņēmieni. Larifan ir bakteriofāga izcelsmes dsRNS (bf-dsRNS), kas iegūta biotehnoloģiskā ceļā no ar bakteriofāgu inficētām E.Coli šūnām. Tai piemīt spējas inducēt interforus (IFN), un tā tiek veiksmīgi pielietota kā pretvīrusu līdzeklis ar retām blakusparādībām. Larifan piemīt arī pret- audzēju aktivitāte. Maģistra darba mērķis bija …
Rifampicin is not an inhibitor of tyrosinase
2022
Rifampicin has been previously described as an inhibitor of tyrosinase (Chai et al., Int. J. Biol. Macromol. 102 (2017) 425–430). However, rifampicin contains a p-diphenol group and compounds with such a moiety have been shown before to reduce tyrosinase-generated o-quinones. Rifampicin also shows strong absorption in a region completely overlapping with the visible absorption band of dopachrome, the oxidation product of L-tyrosine and L-dopa, whose concentration is measured spectrophotometrically in the standard enzymatic assay to monitor the activity of tyrosinase. We have demonstrated that rifampicin is also rapidly oxidized by o-quinones generated from catechols by tyrosinase or by trea…
Lack of reactivation of tuberculosis in patients with psoriasis treated with secukinumab in a real-world setting of latent tuberculosis infection
2022
Background Some biologics for psoriasis, especially anti-tumor necrosis factor (TNF)-alpha therapies, may re-activate latent tuberculosis (TBC) infection with consequent morbidity and mortality. However, there is a low reported incidence of conversion to positive TBC status among patients with psoriasis treated with second-generation biologic therapies, particularly anti-interleukin (IL)-17 therapies such as secukinumab. Objectives To evaluate the safety profile of secukinumab in psoriasis patients with latent TBC infection. Methods Real-life data were collected by retrospective chart review on patients with moderate-to-severe psoriasis who showed positivity for TBC screening at baseline an…
Intestinal protozoa in HIV-infected patients: effect of rifaximin in Cryptosporidium parvum and Blastocystis hominis infections
1999
In HIV-1 infected patients severe enteritis and chronic diarrhea are often documented as a consequence of multiple opportunistic infections. We analyzed 48 HIV-1 positive patients for the presence of intestinal pathogenic protozoa. Patients with CD4 > or = 200/mm3 showed a higher prevalence of a single pathogenic protozoa than patients with CD4 or = 200/mm3, who presented enteric and systemic symptoms due to Criptosporidium or Blastocystis associated with enteropathogenic bacteria
La Llegenda del llibreter assassí de Barcelona. Tradizione e traduzione. Note al margine dell’edizione italiana
2013
Riassunto: La recente pubblicazione in Italia della traduzione de La llegenda del llibreter assassi di Ramon Miquel i Planas offre lo spunto per un confronto con alcune precedenti traduzioni in castigliano e per una breve riflessione di metodo sulla traduzione. Le due versioni spagnole (1991 e 2011) si configurano infatti, a differenza di quella italiana, come libere rielaborazioni dell’originale dal momento che ne alterano la struttura, trasformando il testo e piegandolo a nuove finalita. L’elemento di interesse di questa «manipolazione» risiede nel fatto che essa e in qualche modo autorizzata dalla stessa natura miscellanea dell’opera di Miquel i Planas, al contempo libro erudito e antolo…