Search results for "Risk Analysi"
showing 10 items of 380 documents
Epigenetic biomarkers: Current strategies and future challenges for their use in the clinical laboratory
2017
Epigenetic modifications and regulators represent potential molecular elements which control relevant physiological and pathological features, thereby contributing to the natural history of human disease. These epigenetic modulators can be employed as disease biomarkers, since they show several advantages and provide information about gene function, thus explaining differences among patient endophenotypes. In addition, epigenetic biomarkers can incorporate information regarding the effects of the environment and lifestyle on health and disease, and monitor the effect of applied therapies. Technologies used to analyze these epigenetic biomarkers are constantly improving, becoming much easier…
Analytical Approaches for the Evaluation of Food Protected Designation of Origin
2016
Abstract The state of the art analytical methodologies used to authenticate the origin and composition of foods will be presented in the frame of the protected designation of origin for European labels. The aforementioned labels guarantee the origin and good production practices in the elaboration of foods for human consumption. Target analytes and analytical procedures, together with the chemometric tools used to discriminate foods from different areas or production methods, will be presented and critically discussed. Examples of some of the most commonly evaluated foods in the scientific literature will be also included.
Is quality of life different between diabetic and non-diabetic people? The importance of cardiovascular risks.
2017
BackgroundTo analyse and compare the impact of cardiovascular risk factors and disease on health-related quality of life (HRQoL) in people with and without diabetes living in the community.MethodsWe used data of 1,905 people with diabetes and 19,031 people without diabetes from the last Spanish National Health Survey (years 2011 +/- 2012). The HRQoL instrument used was the EuroQol 5D-5L, based on time trade-off scores. Matching methods were used to assess any differences in the HRQoL in people with and without diabetes with the same characteristics (age, gender, education level, and healthy lifestyle), according to cardiovascular risk factors and diseases. Disparities were also analysed for…
Prevalence and Risk Factors for Vitamin C Deficiency in North and South India: A Two Centre Population Based Study in People Aged 60 Years and Over
2011
BackgroundStudies from the UK and North America have reported vitamin C deficiency in around 1 in 5 men and 1 in 9 women in low income groups. There are few data on vitamin C deficiency in resource poor countries.ObjectivesTo investigate the prevalence of vitamin C deficiency in India.DesignWe carried out a population-based cross-sectional survey in two areas of north and south India. Randomly sampled clusters were enumerated to identify people aged 60 and over. Participants (75% response rate) were interviewed for tobacco, alcohol, cooking fuel use, 24 hour diet recall and underwent anthropometry and blood collection. Vitamin C was measured using an enzyme-based assay in plasma stabilized …
Cross-sectional assessment of nut consumption and obesity, metabolic syndrome and other cardiometabolic risk factors: the PREDIMED study
2013
INTRODUCTION: Prospective studies have consistently suggested that nut consumption is inversely related to fatal and non-fatal coronary heart disease. Limited data are available on the epidemiological associations between nut intake and cardiometabolic risk factors. OBJECTIVE: To evaluate associations between frequency of nut consumption and prevalence of cardiometabolic risk factors [obesity, metabolic syndrome (MetS), type-2 diabetes, hypertension, and dyslipidemia] in a Mediterranean population at high cardiovascular risk. MATERIALS AND METHODS: Cross-sectional study of 7,210 men and women (mean age, 67 y) recruited into the PREDIMED study. MetS was defined by the harmonized ATPIII and I…
Implementation Methodology of the Resilience Framework
2014
Failure of Critical Infrastructures (CIs) can have severe consequences for our societies. Therefore, CI resilience has attracted increasing attention in industries and policy-making. However, empirical studies on CI resilience are rare. In particular, research on the implementation of policies aiming at an improvement of CI resilience is lacking. Using Group Model Building combined with the Delphi method, and surveys we have developed a framework to improve CI resilience. This research identifies policies to enhance CI resilience against major industrial accidents across four dimensions (technical, organizational, economic and social) and proposes a temporal order to ensure that the benefit…
Assessing Effects of eGovernment Initiatives Based on a Public Value Framework
2012
Published version of a chapter in the book: Electronic Government. Also available from the publisher at: http://dx.doi.org/10.1007/978-3-642-33489-4_21 Assessing effects of eGovernment initiatives is considered an important but challenging endeavor. Assessments are, among other things, important to justify e-government investments. They are challenging because they are complex, often based on locally defined indicators, many times over-emphasizing financial effects, imprecise, faced with a number of contingencies and very seldom validated. Consequently, effect assessments can be seen as imprecise and difficult to compare across different initiatives. This paper addresses some of the challen…
Is morphokinetic analysis the answer?
2013
Abstract Efforts aimed at improving pregnancy rates have focused on the search for additional markers of viability to supplement current criteria for embryo selection. Time-lapse technology represents a powerful tool in assisted reproduction for evaluating embryos dynamically. Whilst standard methods of embryo assessment are based on subjective morphology evaluation at discrete time points, thereby limiting the information produced for embryo selection, time-lapse recording introduces several additional morphokinetic parameters for embryo evaluation. This additional information can improve implantation rates and reproductive outcomes. This review surveys available knowledge on time-lapse im…
Safety study of an LNG regasification plant using an FMECA and HAZOP integrated methodology
2015
Abstract A safety analysis was performed to determine possible accidental events in the storage system used in the liquefied natural gas regasification plant using the integrated application of failure modes, effects and criticality analysis (FMECA) and hazard and operability analysis (HAZOP) methodologies. The goal of the FMECA technique is the estimation of component failure modes and their major effects, whereas HAZOP is a structured and systematic technique that provides an identification of the hazards and the operability problems using logical sequences of cause-deviation-consequence of process parameters. The proposed FMECA and HAZOP integrated analysis (FHIA) has been designed as a …
Automating HAZOP analysis of batch processes
1999
Abstract A support system for the hazard and operabilty studies of batch processes is presented. The search of causes and consequences is automatically performed using similar qualitative models, in form of logic minitrees, for the phases of the operation procedure and the equipment units. More models are considered for the equipment units, one for each subtask in wich they are involved. The search algorithm is integrated by rules for subdividing the plant to be analysed in nodes.