Search results for "Risk Analysis"
showing 10 items of 375 documents
Valoración de la ingesta dietética a nivel poblacional mediante cuestionarios individuales: sombras y luces metodológicas
2007
El desarrollo de la moderna metodología necesaria para caracterizar con rigor la ingesta de individuos y poblaciones data de hace sólo dos décadas, cuando germinó la epidemiología nutricional. La razón del carácter reciente de esta disciplina radica en el hecho de que la valoración de la ingesta dietética a nivel poblacional presenta retos complejos, que sólo van siendo superados a medida que investigamos y mejoramos los instrumentos metodológicos disponibles. En el presente artículo se revisan los métodos alternativos para estimar la ingesta de alimentos y nutrientes en los individuos. Tras una sucinta descripción de los métodos indirectos y directos de valoración del consumo alimentario, …
Safety analysis in the LBE-Cooled XADS plant through an integrated use of HAZOP, FAULT TREE and thermalhydraulic transient analyses
2004
A detailed description of possible accidental scenarios, with their frequency of occurrence and their consequences, taking into account both internal and external causes that might contribute to them, can be attained by using the most important risk analysis methodologies (HAZard and OPerability studies, HAZOP; Event Tree, ET; Fault Tree, FT; etc.). As it is known, the Fault Tree methodology is aimed at the evaluation of the frequency of an undesired accidental event (Top Event, TE), and is used to describe this one as a combination of primary events identified, for example, by a HAZOP analysis [1]. However, the classic HAZOP analysis, while allowing to perform an exhaustive study of the ex…
Putting the “bio” in “biotherapeutics”/checkpoints for biosimilars/application of biosimilars
2016
Abstract / Executive summary The number of biosimilar medicines on the market is steadily increasing, due, in part, to patent expiration of several top-selling biologic medicines. These three e-learning modules discuss the basic concepts behind biosimilar medicines and highlight key regulatory considerations when using biosimilar medicines in medical practice.
Open Data Quality Evaluation: A Comparative Analysis of Open Data in Latvia
2020
Nowadays open data is entering the mainstream - it is free available for every stakeholder and is often used in business decision-making. It is important to be sure data is trustable and error-free as its quality problems can lead to huge losses. The research discusses how (open) data quality could be assessed. It also covers main points which should be considered developing a data quality management solution. One specific approach is applied to several Latvian open data sets. The research provides a step-by-step open data sets analysis guide and summarizes its results. It is also shown there could exist differences in data quality depending on data supplier (centralized and decentralized d…
Defining and measuring the network flexibility of humanitarian supply chains: insights from the 2015 Nepal earthquake
2019
International audience; The efficient and effective response to disasters critically depends on humanitarian supply chains (HSCs). HSCs need to be flexible to adapt to uncertainties in needs, infrastructure conditions, and behavior of other organizations. The concept of ‘network flexibility’ is, however, not clearly defined. The lack of an unanimous definition has led to a lack of consistent understanding and comparisons. This paper makes a threefold contribution: first, it defines the concept of network flexibility for HSC in the context of sudden onset disasters. Second, it proposes a framework to measure network flexibility in HSCs. Third, we apply our framework to the 2015 Nepal earthqu…
Assessing Cloud Infrastructure Costs in Communications-Intensive Applications
2012
By deploying cloud infrastructure services, companies strive at achieving faster time to market, improved scalability, lower up-front costs, and lower IT management overhead, among other benefits. However, in longer term, the use of cloud infrastructure may incur significant costs; furthermore, these costs depend both on the required infrastructure resources and on the mode of infrastructure deployment. Therefore, the choice of a particular deployment mode should be justified with a systematic analysis of the associated costs. In this paper, a model for assessing the costs of alternative cloud infrastructure deployment scenarios is introduced. This model decomposes the infrastructure costs …
Safety studies of a hydrogen refuelling station: Determination of the occurrence frequency of the accidental scenarios
2009
At present, the hydrogen vehicles technology appears to have future Prospective for reduction in greenhouse gas emissions. Nevertheless, the development of such a technology requires appropriate infrastructures for production, Storage and refuelling stages in a refuelling station. This one presents safety challenges due to the hydrogen chemicophysical characteristics. So, to avoid hazards, it is necessary to implement safety practices that, if early adopted in the development of a fuelling station project, can allow very low impact, safety being incorporated in the project itself. However, a drawback is the not sufficient experience and the scarcity of the relevant data collection. To deepe…
Risk Assessment and Analysis
2014
Once threats are identified, they must be assessed or evaluated, which is the objective of this chapter. There is usually a large number of threats, making it impossible or unprofitable to analyze them all, meaning selection of the threats that will be addressed is important. It is a decision-making process; an example is proposed and solved by one of the many techniques available. The chapter proposes a very standard requested study, which is the assessment of the economic and financial risks of a project. This is done through a real-life-example, followed by another appraisal, this time devoted to economic issues, as well as another for transportation, introducing the important concept of…
EVALUATION OF EFFICIENCY IN THE PUBLIC SECTOR
2016
The paper is focused on the efficiency of government activities and possibilities of evaluating it. Nowadays an appropriate use of public finances is an urgent problem of financial management of the state. Therefore, a special emphasis is put on the necessity to evaluate the results of activities of the public sector. These results have become an important element of the public financial system oriented towards results, as they form a stable base for planning and evaluating government budget resources. Being unaware of results, it is impossible to estimate if the aims and tasks set by the government financial policy are real and appropriate to the current situation and financial resources. …
Confidence, tolerance, and allowance in biological engineering: The nuts and bolts of living things
2014
The emphasis of systems and synthetic biology on quantitative understanding of biological objects and their eventual re-design has raised the question of whether description and construction standards that are commonplace in electric and mechanical engineering are applicable to live systems. The tuning of genetic devices to deliver a given activity is generally context-dependent, thereby undermining the re-usability of parts, and predictability of function, necessary for manufacturing new biological objects. Tolerance (acceptable limits within the unavoidable divergence of a nominal value) and allowance (deviation introduced on purpose for the sake of flexibility and hence modularity, i.e. …