Search results for "Risk analysis"
showing 10 items of 375 documents
Uncertainty in urban stormwater quality modelling: The influence of likelihood measure formulation in the GLUE methodology
2009
In the last years, the attention on integrated analysis of sewer networks, wastewater treatment plants and receiving waters has been growing. However, the common lack of data in the urban water-quality field and the incomplete knowledge regarding the interpretation of the main phenomena taking part in integrated urban water systems draw attention to the necessity of evaluating the reliability of model results. Uncertainty analysis can provide useful hints and information regarding the best model approach to be used by assessing its degrees of significance and reliability. Few studies deal with uncertainty assessment in the integrated urban-drainage field. In order to fill this gap, there ha…
Ensuring the Consistency of Biosimilars
2017
Background: Biological products are subject to constant reappraisal by regulatory agencies and pharmaceutical companies once they have entered the market, since every improvement in their manufacturing process has the potential to alter the basic properties of these molecules. Methods: Narrative review focusing on scientific literature as well as legal documents from regulatory agencies. Results: Evaluating the impact of each manufacturing change of these drugs requires rigorous analyses in proportion to the anticipated risk of inducing more or less molecular micro-heterogenicity. There are currently more than 30 biosimilars of TNF-alpha blockers at different stages of testing, each with a …
SU-F-T-248: FMEA Risk Analysis Implementation (AAPM TG-100) in Total Skin Electron Irradiation Technique
2016
Purpose: Total Skin Electron Irradiation (TSEI) is a radiotherapy treatment which involves irradiating the entire body surface as homogeneously as possible. It is composed of an extensive multi-step technique in which quality management requires high consumption of resources and a fluid communication between the involved staff, necessary to improve the safety of treatment. The TG-100 proposes a new perspective of quality management in radiotherapy, presenting a systematic method of risk analysis throughout the global flow of the stages through the patient. The purpose of this work has been to apply TG-100 approach to the TSEI procedure in our institution. Methods: A multidisciplinary team s…
Quality Improvement Based on Big Data Analysis
2016
Big data analysis has become an important trend in computer science. Quality improvement is a constant in current industry trends. In this paper, we present an idea of quality improvement based on big data analysis with the aid of linked data and ontologies in order to implement it in the case of automotive parts production. We consider defective automotive products and try to find the best refurbishment solution for them considering their characteristics. Moreover, we propose to develop a recommender system that is able to give recommendations in order to prevent or to alleviate defects and to provide insights for possible causes that led to these defective parts. This study intends to hel…
Anthropic space and design for all. New knowledge paths for urban planning strategies
2019
Abstract Nowadays city environment shows the presence of a mixed variety of elements, as natural, semi natural and anthropic components that build up both structure and connections of the urban context. This specific structure shapes and directs space and its functions strictly connected with their sustainable potential uses and sustainable development opportunities. The lack of rules and proper planning methods produces inefficient use conditions by resident citizens, entropy, functions' reduction of ecological networks and deep environmental impacts. The consequence comes out to be a great widespread life quality decrease in urban areas. These thoughts lead the authors to rethink the defi…
Toward a holistic environmental impact assessment of marble quarrying and processing: proposal of a novel easy-to-use IPAT-based method.
2016
Marble is a natural dimension stone that is widely used in building due to its resistance and esthetic qualities. Unfortunately, some concerns have arisen regarding its production process because quarrying and processing activities demand significant amounts of energy and greatly affect the environment. Further, performing an environmental analysis of a production process such as that of marble requires the consideration of many environmental aspects (e.g., noise, vibrations, dust and waste production, energy consumption). Unfortunately, the current impact accounting tools do not seem to be capable of considering all of the major aspects of the (marble) production process that may affect th…
Time-lapse technology: evaluation of embryo quality and new markers for embryo selection
2012
Current methods of embryo evaluation rely mainly on static observations of the embryo´s morphology. These observations are inevitably restricted to specific times and, considering that the development of the embryo is a dynamic process, several critical stages in between observations may go unnoticed. These methods are also very subjective, and variations between embryologists may affect critical decisions that will, in turn, affect the overall success of the IVF clinics. On the other hand, an increased number of multiple pregnancies calls for a reduction in the number of embryos transferred, making the selection procedure even more challenging for the embryologist. Therefore, new markers t…
Components of software development risk: how to address them? A project manager survey
2000
Software risk management can be defined as an attempt to formalize risk oriented correlates of development success into a readily applicable set of principles and practices. By using a survey instrument we investigate this claim further. The investigation addresses the following questions: 1) What are the components of software development risk? 2) how does risk management mitigate risk components, and 3) what environmental factors if any influence them? Using principal component analysis we identify six software risk components: 1) scheduling and timing risks, 2) functionality risks, 3) subcontracting risks, 4) requirements management, 5) resource usage and performance risks, and 6) person…
Characterizing antibiotics in LCA-a review of current practices and proposed novel approaches for including resistance
2021
Abstract Purpose With antibiotic resistance (ABR) portrayed as an increasing burden to human health, this study reviews how and to what extent toxicological impacts from antibiotic use are included in LCAs and supplement this with two novel approaches to include ABR, a consequence of antibiotic use, into the LCA framework. Methods We review available LCA studies that deal with toxicological aspects of antibiotics to evaluate how these impacts from antibiotics have been characterized. Then, we present two novel approaches for including ABR-related impacts in life cycle impact assessments (LCIAs). The first approach characterizes the potential for ABR enrichment in the environmental compartme…