Search results for "Risk factor."

showing 10 items of 4316 documents

Focus on the unique mechanisms involved in thoracic aortic aneurysm formation in bicuspid aortic valve versus tricuspid aortic valve patients: clinic…

2013

OBJECTIVES: The involvement of different factors in the onset of thoracic aortic aneurysm (TAA) in patients with a bicuspid aortic valve (BAV) vs those with a tricuspid aortic valve (TAV) is well recognized. However, the molecular, genetic and cellular mechanisms driving TAA remain unclear. The aim of this study was to identify the different mechanisms involved in TAA development in patients with BAV vs TAV. METHODS: Aorta specimens and DNA samples were collected from 24 BAV (18 men and 6 women; mean age: 54.2 ± 14.39 years) and 110 TAV (79 men and 31 women, mean age: 66 ± 9.8 years) patients. A control group of 128 subjects (61 men and 67 woman, mean age: 61.1 ± 5.8 years) was also enrolle…

Aortic valveMaleThoracicHeart Valve DiseasesApoptosisPilot ProjectsBicuspid aortic valve; Clinical implications; Identifying different genetic and histological profiles; Thoracic aortic aneurysm; Tricuspid aortic valve; Adult; Aged; Aortic Aneurysm Thoracic; Aortic Valve; Apoptosis; Comorbidity; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Heart Valve Diseases; Histocytochemistry; Humans; Male; Matrix Metalloproteinase 9; Middle Aged; Pilot Projects; Polymorphism Single Nucleotide; Risk Factors; Tricuspid ValveComorbidityBicuspid aortic valveBicuspid Aortic Valve DiseaseGene FrequencyFibrosisRisk FactorsClinical implicationsTricuspid valvebiologyHistocytochemistryGeneral MedicineSingle NucleotideMiddle AgedAortic Aneurysmmedicine.anatomical_structureMatrix Metalloproteinase 9Aortic ValveCardiologyFemaleTricuspid ValveCardiology and Cardiovascular MedicinePulmonary and Respiratory MedicineAdultmedicine.medical_specialtyBicuspid aortic valveGenotypeThoracic aortic aneurysmTricuspid aortic valvePolymorphism Single Nucleotidemedicine.arteryInternal medicineThoracic aortic aneurysmAscending aortamedicineSettore MED/05 - Patologia ClinicaHumansGenetic Predisposition to DiseasePolymorphismIdentifying different genetic and histological profilesAgedAortaAortic Aneurysm Thoracicbusiness.industryAngiotensin-converting enzymeSettore MED/23 - Chirurgia Cardiacamedicine.diseasebiology.proteinSurgerybusinessEuropean journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
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Outcomes of aortic valve repair according to valve morphology and surgical techniques

2012

OBJECTIVES: The aim of this study was to assess the impact of aortic valve morphology and different surgical aortic valve repair techni- ques on long-term clinical outcomes. METHODS: Between February 2003 and May 2010, 216 patients with aortic insufficiency underwent aortic valve repair in our institu- tion. Ages ranged between 26 and 82 years (mean 53 ± 15 years). Aortic valve dysfunctions, according to functional classification, were: type I in 55 patients (25.5%), type II in 126 (58.3%) and type III in 35 (16.2%). Sixty-six patients (27.7%) had a bicuspid valve. Aortic valve repair techniques included sub-commissural plasty in 138 patients, plication in 84, free-edge reinforcement in 80,…

Aortic valveMaleTime Factorsmedicine.medical_treatmentKaplan-Meier EstimateAortic valve repairRecurrenceRisk FactorsMitral valve80 and overHospital MortalityCoronary Artery BypassAortaUltrasonographyAged 80 and overTricuspid valveCalcinosisCardiac Valve AnnuloplastyMiddle AgedAortic valve repair • Bicuspid aortic valve • Tricuspid aortic valve • Aortic annulus stabilization medicine.anatomical_structureTreatment OutcomeAortic ValveReplantationcardiovascular systemCardiologyChordae TendineaeMitral ValveFemaleChordae tendineaeCardiology and Cardiovascular MedicineAdult; Aged; Aged 80 and over; Aorta; Aortic Valve; Aortic Valve Insufficiency; Blood Vessel Prosthesis Implantation; Calcinosis; Chordae Tendineae; Coronary Artery Bypass; Disease-Free Survival; Female; Hospital Mortality; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Mitral Valve; Proportional Hazards Models; Recurrence; Replantation; Risk Assessment; Risk Factors; Time Factors; Treatment Outcome; Ultrasonography; Cardiac Valve Annuloplasty; Suture TechniquesPulmonary and Respiratory MedicineAdultmedicine.medical_specialtyAortic Valve InsufficiencyRisk AssessmentCardiac Valve AnnuloplastyDisease-Free SurvivalBlood Vessel Prosthesis ImplantationBicuspid valveInternal medicinemedicineHumansAgedProportional Hazards ModelsMitral valve repairbusiness.industrySuture TechniquesSettore MED/23 - Chirurgia CardiacaOriginal ArticlesSurgerySurgerybusiness
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A multicentre European registry to evaluate the Direct Flow Medical transcatheter aortic valve system for the treatment of patients with severe aorti…

2016

Aims Our aim was to assess the clinical outcomes of the Direct Flow Medical Transcatheter Aortic Valve System (DFM-TAVS), when used in routine clinical practice. Methods and results This is a prospective, open-label, multicentre, post-market registry of patients treated with DFM-TAVS according to approved commercial indications. Echocardiographic and angiographic data were evaluated by an independent core laboratory and adverse events were adjudicated and classified according to VARC-2 criteria by an independent clinical events committee. The primary endpoint was freedom from all-cause mortality at 30 days post procedure. Secondary endpoints included procedural, early safety and efficacy en…

Aortic valveMalemedicine.medical_specialtyCardiac Catheterizationmedicine.medical_treatmentAortic Valve InsufficiencyRegurgitation (circulation)030204 cardiovascular system & hematologyTranscatheter Aortic Valve Replacement03 medical and health sciences0302 clinical medicineRisk FactorsInternal medicinemedicineClinical endpointHumans030212 general & internal medicineHeart valveProspective StudiesRegistriesCardiac catheterizationAgedAged 80 and overHeart Valve Prosthesis Implantationbusiness.industryAortic Valve Stenosismedicine.disease3. Good healthClinical trialStenosismedicine.anatomical_structureTreatment OutcomeAortic valve stenosisAortic ValveHeart Valve ProsthesisCardiologyFemaleCardiology and Cardiovascular MedicinebusinessEuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
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Incidence, Predictive Factors, and Prognostic Impact of Silent Atrial Fibrillation After Transcatheter Aortic Valve Implantation.

2018

New onset atrial fibrillation post-transcatheter aortic valve implantation (TAVI) is common and is associated with adverse outcomes. However, silent atrial fibrillation (AF) is poorly documented in the context. This study sought to evaluate the incidence, predictive factors, and prognostic value of Silent AF post-TAVI. All the consecutive patients with TAVI were prospectively analyzed by continuous electrocardiogram monitoring≥48 hours after implantation. Silent AF was defined as asymptomatic episodes lasting at least 30 seconds. The population was divided into 3 groups: history of AF, no-AF, and silent AF. Among the 206 patients implanted with TAVI, 19 (16.1%) developed silent AF. Compared…

Aortic valveMalemedicine.medical_specialtyTime FactorsPopulationContext (language use)030204 cardiovascular system & hematologyAsymptomaticTranscatheter Aortic Valve Replacement03 medical and health sciencesElectrocardiography0302 clinical medicinePostoperative ComplicationsRisk FactorsInternal medicineAtrial FibrillationmedicineHumans030212 general & internal medicineProspective StudiesRegistriesProspective cohort studyeducationAged 80 and overeducation.field_of_studymedicine.diagnostic_testbusiness.industryIncidenceAtrial fibrillationAortic Valve Stenosismedicine.diseasePrognosismedicine.anatomical_structureAortic valve stenosisAortic ValveCardiologyFemaleFrancemedicine.symptomCardiology and Cardiovascular MedicinebusinessElectrocardiographyFollow-Up StudiesThe American journal of cardiology
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Echocardiographic and angiographic evaluation of left ventricular function during percutaneous transluminal aortic valvuloplasty.

1992

Transesophageal echocardiography was used to study the effect of the balloon inflation on left ventricular function in 20 patients with critical aortic stenosis undergoing balloon valvuloplasty. Balloon inflation caused an increase of end-diastolic (15% to 34%) and end-systolic (57% to 72%) left ventricular volume. Left ventricular wall stress increased from 30 +/- 10 x 10(3) dyn/cm2 at diastole and 121 +/- 40 x 10(3) dyn/cm2 at systole to 44 +/- 11 x 10(3) dyn/cm2 and 191 +/- 55 x 10(3) dyn/cm2, respectively, when the balloon was inflated (P less than 0.05). Turbulent regurgitant jet across the mitral valve increased from 15 +/- 2% to 25 +/- 3% during balloon inflation (P less than 0.01). …

Aortic valveMalemedicine.medical_specialtymedicine.medical_treatmentDiastoleMyocardial InfarctionBalloonCoronary AngiographyVentricular Function LeftCatheterizationRisk FactorsMitral valveInternal medicineCoronary CirculationmedicineHumansSystoleCardiac OutputAgedAged 80 and overbusiness.industryHemodynamicsMitral Valve InsufficiencyBlood flowAortic Valve StenosisMiddle Agedmedicine.diseaseAortic valvuloplastyStenosismedicine.anatomical_structureEchocardiographyAortic Valvecardiovascular systemCardiologyFemaleCardiology and Cardiovascular MedicinebusinessCatheterization and cardiovascular diagnosis
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Identification of cardiac organ damage in arterial hypertension: insights by echocardiography for a comprehensive assessment

2020

: Arterial hypertension, a widespread disease, whose prevalence increases with age, represents a major risk factor for cardiovascular events, causing damage in several organs, including the heart. In this context, echocardiography has a clear and pivotal role, being able to assess cardiac morphology and detect haemodynamic changes induced by this disease. 2018 European Society of Cardiology/European Society of Hypertension guidelines on AH identified main echo parameters such as left ventricular mass, relative wall thickness and left atrial volume, for detecting cardiac organ damage. The present review highlights the advantage of additional echocardiographic parameters such as diastolic mea…

Aortic valvemedicine.medical_specialtyarterial hypertensionPhysiologyHeart VentriclesDiastoleHemodynamicsContext (language use)Speckle tracking echocardiographyRegurgitation (circulation)030204 cardiovascular system & hematologyarterial hypertension; cardiac organ damage; diastolic dysfunction; echocardiography; left ventricular hypertrophy03 medical and health sciences0302 clinical medicinecardiac organ damageInternal medicineInternal MedicineMedicineHumans030212 general & internal medicineRisk factorbusiness.industrymedicine.diseasePrognosisleft ventricular hypertrophyStenosismedicine.anatomical_structureEchocardiographyAortic ValveHypertensionCardiologydiastolic dysfunctionCardiology and Cardiovascular Medicinebusiness
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Reductive stress in young healthy individuals at risk of Alzheimer disease.

2013

Oxidative stress is a hallmark of Alzheimer disease (AD) but this has not been studied in young healthy persons at risk of the disease. Carrying an Apo e4 allele is the major genetic risk factor for AD. We have observed that lymphocytes from young, healthy persons carrying at least one Apo e4 allele suffer from reductive rather than oxidative stress, i.e., lower oxidized glutathione and P-p38 levels and higher expression of enzymes involved in antioxidant defense, such as glutamylcysteinyl ligase and glutathione peroxidase. In contrast, in the full-blown disease, the situation is reversed and oxidative stress occurs, probably because of the exhaustion of the antioxidant mechanisms just ment…

Apolipoprotein EAdultMaleAntioxidantGenotypemedicine.medical_treatmentApolipoprotein E4DiseaseBiologymedicine.disease_causeBiochemistryAntioxidantschemistry.chemical_compoundAlzheimer DiseaseRisk FactorsPhysiology (medical)medicineHumansAlleleAlleleschemistry.chemical_classificationGlutathione PeroxidaseGlutathione peroxidaseGlutathioneMiddle Agedmedicine.diseaseGlutathioneOxidative StresschemistryImmunologyFemaleLipid PeroxidationAlzheimer's diseaseOxidative stressBiomarkersFree radical biologymedicine
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Sharing pathogenetic mechanisms between acute myocardial infarction and Alzheimer's disease as shown by partially overlapping of gene variant profile…

2011

Abstract Gene variants that promote inflammation and cholesterol metabolism have been associated with acute myocardial infarction (AMI) and Alzheimer's disease (AD). We investigated a panel of relevant polymorphisms to distinguish genetic backgrounds for AMI and AD: IL10 -1082G/A, IL6 -174G/C, TNF -308G/A, IFNG +874T/A, SERPINA3 -51G/T, HMGCR -911C/A, APOE e2/3/4 (280 AMI cases, 257 AD cases, and 1307 population controls, all Italian (presumed risk alleles are shown in bold). Six genetic risk sets I to VI were identified by fuzzy latent classification: I had low risk; II and III had low risk before age 65 (II, III); low risk sets lacked pro-inflammatory alleles for HMGCR-TNF-APOE. Pro-infla…

Apolipoprotein EAdultMalePopulationMyocardial InfarctionDiseaseAlzheimer DiseaseRisk FactorsGenes OverlappingMedicineHumansSettore MED/05 - Patologia ClinicaGenetic Predisposition to DiseaseMyocardial infarctionAlleleeducationgenetic risk markers common soil alzheimer disease AMI GOM analysysGeneAgedGeneticsAged 80 and overeducation.field_of_studybusiness.industryGeneral NeuroscienceGene Expression ProfilingGenetic VariationGeneral MedicineMiddle Agedmedicine.diseasePsychiatry and Mental healthClinical PsychologyRelative riskImmunologyTumor necrosis factor alphaFemaleGeriatrics and Gerontologybusiness
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Association of plasma markers of cholesterol homeostasis with metabolic syndrome components. A cross-sectional study.

2011

Abstract Background and aims Increased plasma phytosterols, which reflect enhanced cholesterol absorption, have been related to an increased risk of cardiovascular disease (CVD). However, high CVD risk conditions, such as obesity, diabetes and the metabolic syndrome (MetS) have been associated with reduced cholesterol absorption. We investigated associations between plasma noncholesterol sterols and MetS components. Methods and results With a cross-sectional design, we related MetS components to plasma noncholesterol sterol-to-cholesterol ratios measured by gas chromatography in 674 dyslipidemic patients and 361 healthy subjects participating in a prospective cohort study. Plasma phytostero…

Apolipoprotein EAdultMalemedicine.medical_specialtyGenotypeEndocrinology Diabetes and MetabolismMedicine (miscellaneous)LathosterolBiologychemistry.chemical_compoundHigh-density lipoproteinApolipoproteins ERisk FactorsInternal medicineDiabetes mellitusmedicineHomeostasisHumansProspective StudiesProspective cohort studyMetabolic SyndromeNutrition and DieteticsPhytosterolsOdds ratioMiddle Agedmedicine.diseaseLipid MetabolismSitosterolsEuropean Prospective Investigation into Cancer and NutritionEndocrinologyCholesterolCross-Sectional StudiesPhenotypechemistryCardiovascular Diseaseslipids (amino acids peptides and proteins)FemaleMetabolic syndromeCardiology and Cardiovascular MedicineBiomarkersNutrition, metabolism, and cardiovascular diseases : NMCD
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Vascular effects of diet supplementation with plant sterols.

2008

Objectives The purpose of this study was to evaluate vascular effects of diet supplementation with plant sterol esters (PSE). Background Plant sterol esters are used as food supplements to reduce cholesterol levels. Their effects on endothelial function, stroke, or atherogenesis are not known. Methods In mice, plasma sterol concentrations were correlated with endothelial function, cerebral lesion size, and atherosclerosis. Plasma and tissue sterol concentrations were measured by gas-liquid chromatography-mass spectrometry in 82 consecutive patients with aortic stenosis. Results Compared with those fed with normal chow (NC), wild-type mice fed with NC supplemented with 2% PSE showed increase…

Apolipoprotein EAortic valveMalemedicine.medical_specialtyDiet therapyArteriosclerosisCardiovascular SystemBrain Ischemiachemistry.chemical_compoundMiceEzetimibeRisk FactorsInternal medicinepolycyclic compoundsmedicineAnimalsHumansEndotheliumAgedCholesterolbusiness.industryPhytosterolsSterolMice Inbred C57BLEndocrinologymedicine.anatomical_structurechemistryCirculatory systemDietary Supplementslipids (amino acids peptides and proteins)FemalePlant PreparationsCardiology and Cardiovascular MedicinebusinessBlood vesselmedicine.drugJournal of the American College of Cardiology
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