Search results for "Rite"
showing 10 items of 2726 documents
Angiotensin II dependent cardiac remodeling in the eel Anguilla anguilla involves the NOS/NO system
2017
Angiotensin II (AngII), the principal effector of the Renin-Angiotensin System (RAS), plays an important role in controlling mammalian cardiac morpho-functional remodelling. In the eel Anguilla anguilla, one month administration of AngII improves cardiac performance and influences the expression and localization of molecules which regulate cell growth. To deeper investigate the morpho-functional chronic influences of AngII on the eel heart and the molecular mechanisms involved, freshwater eels (A. anguilla) were intraperitoneally injected for 2 months with AngII (1 nmol g BW-1). Then the isolated hearts were subjected to morphological and western blotting analyses, and nitrite measurements.…
Pharmacogenomic Characterization of Cytotoxic Compounds from Salvia officinalis in Cancer Cells.
2015
Salvia officinalis is used as a dietary supplement with diverse medicinal activity (e.g. antidiabetic and antiatherosclerotic effects). The plant also exerts profound cytotoxicity toward cancer cells. Here, we investigated possible modes of action to explain its activity toward drug-resistant tumor cells. Log10IC50 values of two constituents of S. officinalis (ursolic acid, pomolic acid) were correlated to the expression of ATP-binding cassette (ABC) transporters (P-glycoprotein/ABCB1/MDR1, MRP1/ABCC1, BCRP/ABCG2) and epidermal growth factor receptor (EGFR) or mutations in RAS oncogenes and the tumor suppressor gene TP53 of the NCI panel of cell lines. Gene expression profiles predicting se…
Co-maternité : entre désir et réalité
2011
International audience
Crystal structure of sinhalite MgAlBO4 under high pressure
2015
We report on high-pressure angle-dispersive X-ray diffraction data up to 27 GPa for natural MgAlBO4 sinhalite mineral and ab initio total energy calculations. The experimental bulk modulus of sinhalite is B-0 = 171(3) GPa with a first-pressure derivative of B-0' = 4.2(3). A comparison with other olivine-type compounds shows that the value for B0 is 27% larger than that of Mg2SiO4 forsterite and 29% smaller than that of Al2BeO4 chrysoberyl. These differences are interpreted, on the basis of our ab initio calculations, in terms of the relative incompressibility of Al-O bonds in AlO6 octahedra (with a calculated bulk modulus of 250(1) GPa) as compared to Mg-O bonds in MgO6 octahedra (with a ca…
Cytotoxicity of cucurbitacin E from Citrullus colocynthis against multidrug-resistant cancer cells
2019
Abstract Background Cucurbitacin E (CuE) is an oxygenated tetracyclic triterpenoid isolated from the fruits of Citrullus colocynthis (L.) Schrad. Purpose This study outlines CuE's cytotoxic activity against drug-resistant tumor cell lines. Three members of ABC transporters superfamily, P-glycoprotein (P-gp), breast cancer resistance protein (BCRP) and ABCB5 were investigated, whose overexpression in tumors is tightly linked to multidrug resistance. Further factors of drug resistance studied were the tumor suppressor TP53 and the epidermal growth factor receptor (EGFR). Methods Cytotoxicity assays (resazurin assays) were used to investigate the activity of Citrullus colocynthis and CuE towar…
The Intention-to-Treat Effect of Bridging Treatments in the Setting of Milan Criteria–In Patients Waiting for Liver Transplantation
2019
In patients with hepatocellular carcinoma (HCC) meeting the Milan criteria (MC), the benefit of locoregional therapies (LRTs) in the context of liver transplantation (LT) is still debated. Initial biases in the selection between treated and untreated patients have yielded conflicting reported results. The study aimed to identify, using a competing risk analysis, risk factors for HCC-dependent LT failure, defined as pretransplant tumor-related delisting or posttransplant recurrence. The study was registered at www.clinicaltrials.gov (identification number NCT03723304). In order to offset the initial limitations of the investigated population, an inverse probability of treatment weighting (IP…
L’abside in facciata: soluzioni “antisismiche” del XVIII secolo in Sicilia
2015
Nel corso del Settecento vennero progettate e costruite in Sicilia facciate chiesastiche caratterizzate da conformazioni curvilinee. Forme convesse e concave, posizionate in corrispondenza del partito centrale della facciata rendono queste strutture assimilabili alle absidi. Scelte di natura estetica hanno inizialmente innescato fenomeni emulativi sulla base della ricezione dei modelli diffusi dalla seconda metà del Seicento in Sicilia dalle incisioni riproducenti le facciate inflesse prodotte dai maestri del Barocco romano. Finora l'interesse verso questi modelli è apparso lo schema interpretativo più pertinente per spiegare gli indirizzi progettuali dei maggiori artefici operanti nel Sett…
Hybrid layers of etch-and-rinse versus self-etching adhesive systems.
2010
Objective: To evaluate the effectiveness in the formation of resin tags, adhesive lateral branches and hybrid layers of five adhesive systems, when bonding to dentine. Material and Methods: Flat dentin surfaces from 25 molars were bonded with several adhesive systems according to the manufacturers? instructions. Composite build-ups were constructed incrementally with Tetric Ceram. The Specimens were sectioned parallel to the long axis. One section was treated with phosphoric acid and sodium hypochlorite in order to reveal the hybrid layer formation. The other section was stored in 30% hydrochloric acid to detect resin tags and adhesive lateral branch formation. Results: The two etch-and-rin…
Prestazioni di accessibilità nei siti archeologici: criteri per la valutazione e miglioramento
2021
Knowledge of the heritage on the part of the visitor is the premise for its conservation and enhancement. In order to appreciate the identity of the site completely, the visitor must enter into an active relationship with the heritage, in a multi-sensorial, safe and comfortable manner. But is this always the case? Archaeological heritage is considered a sort of limited case, in which the general critical conditions of accessibility are emphasized. For this reason, this research, applying a systemic approach, is geared towards evaluating whether, in some of these sites, selected as case-studies, the solutions for accessibility comply with technical and performance features in accordance with…
Carbonate/evaporitic sedimentation during the Messinian salinity crisis in active accretionary wedge basins of the northern Calabria, southern Italy
2020
Abstract This work deals with Messinian deposits belonging to the Neogene infill of the Rossano and Belvedere Basins, respectively developed along the fore-arc and the back-arc areas of the north Calabria accretionary wedge. The main goal is to characterize the carbonate and evaporitic sedimentation during the Messinian Salinity Crisis, in the general framework of the basin architecture and the interplay between eustatic vs tectonic controlled sea-level variations. Fieldwork integrated with seismic lines and well logs interpretations led to the revision of the general stratigraphy of the basins and the proposal of a new sequential stratigraphic model driven by cyclic sea-level variations. E…