Search results for "Rli47"
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Étude des interconnexions dans les réseaux de régulation de Listeria monocytogenes en réponse aux conditions de l'environnement
2019
The facultative intracellular pathogen Listeria monocytogenes is a highly adaptable organism widely distributed in the environment. The ingestion of food contaminated with L. monocytogenes by at-risk individuals can ultimately lead to listeriosis, one of the leading causes of food-borne fatalities in developed countries. Regulatory networks are crucial for the adaptation and survival of this pathogen. The accessory gene regulator (Agr) system has been shown to be involved in virulence, biofilm formation, and survival of L. monocytogenes, affecting the transcription of over 700 genes. The alternative sigma factor Sigma B (σB) controls the general stress response in L. monocytogenes, regulati…
The σ B -dependent regulatory sRNA Rli47 represses isoleucine biosynthesis in Listeria monocytogenes through a direct interaction with the ilvA trans…
2019
International audience; The facultative intracellular pathogen Listeria monocytogenes can persist and grow in a diverse range of environmental conditions, both outside and within its mammalian host. The alternative sigma factor Sigma B (sigma(B)) plays an important role in this adaptability and is critical for the transition into the host. While some of the functions of the sigma(B) regulon in facilitating this transition are understood the role of sigma(B)-dependent small regulatory RNAs (sRNAs) remain poorly characterized. In this study, we focused on elucidating the function of Rli47, a sigma(B)-dependent sRNA that is highly induced in the intestine and in macrophages. Using a combinatio…