Search results for "Rna expression"

showing 3 items of 43 documents

Centenarian offspring: A model for understanding healthy aging

2018

Centenarians exhibit extreme longevity showing a compression of morbidity. We showed previously that microRNA expression profiles and plasma protein carbonylation in centenarians and young people are similar, whereas they are very different from that found in old individuals. This suggests that centenarians have a better control of homeostasis and are protected against oxidative damage. In this study, we aimed to determine if such characteristic microRNA expression profile and lower protein oxidation status in centenarians may be inherited by their offspring. For this purpose, we collected plasma and peripheral blood mononuclear cells from 90 septuagenarians, 68 centenarians and 46 centenar…

medicine.medical_specialtyOffspringProtein CarbonylationMicroRNA Expression ProfileBiologyProtein oxidationBiochemistryPeripheral blood mononuclear cellBlood proteinsEndocrinologyPhysiology (medical)Internal medicinemicroRNAmedicineCentenarianFree Radical Biology and Medicine
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Oxidative stress and mrna expression after an oral unsaturated fat load test in subjects with abdominal obesity

2014

medicine.medical_specialtybusiness.industryMrna expressionUnsaturated fatmedicine.disease_causechemistry.chemical_compoundEndocrinologychemistryInternal medicinemedicinemedicine.symptomCardiology and Cardiovascular MedicinebusinessAbdominal obesityOxidative stressAtherosclerosis
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Glucose transporter 4 mRNA expression in subcutaneous adipose tissue of women with PCOS remains unchanged despite metformin withdrawal: is there a ce…

2021

Purpose: Metformin induces GLUT-4 mRNA expression in insulin target tissues in PCOS. It is unclear how long this impact is sustained after withdrawal of metformin. We aimed to compare the effect of metformin withdrawal on GLUT-4 mRNA expression in subcutaneous adipose tissue after prior short (ST, 1 year, N = 11) and long term (LT, at least 3 years, N = 13) treatment in obese PCOS women. Methods: At baseline and 6 months after withdrawal, biopsy of subcutaneous adipose tissue followed by quantitative PCR analysis was performed to determine GLUT-4 mRNA expression. Results: We found no time/effect differences in GLUT-4 mRNA expression in ST (2-dCt at baseline 0.42 (0.16–0.48) vs 2-dCt after 6…

medicine.medical_specialtyendocrine system diseasesEndocrinology Diabetes and Metabolismmedicine.medical_treatmentMrna expressionGlucose Transport Proteins FacilitativeSubcutaneous FatAdipose tissueQuantitative PCR analysisEndocrinologyInternal medicineBiopsymedicineHumansRNA MessengerAdipose tissue GLUT-4 mRNA Metformin PCOS Adipose Tissue Female Humans RNA Messenger Subcutaneous Fat Metformin Polycystic Ovary Syndromemedicine.diagnostic_testbusiness.industryInsulinGlucose transporternutritional and metabolic diseasesMetforminMetforminEndocrinologyAdipose TissueFemaleSubcutaneous adipose tissuebusinessPolycystic Ovary Syndromemedicine.drug
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