Search results for "Roca"
showing 10 items of 1893 documents
Ischemic type biliary lesions in histidine-tryptophan-ketoglutarate (HTK) preserved liver grafts.
2006
Ischemic type biliary lesions lead to considerable morbidity following orthotopic liver transplantation. The exact pathogenesis is unknown. One major hypothesis is that insufficient perfusion of the arterial vessels of the biliary tree, especially under perfusion with the high viscous University of Wisconsin solution, might be responsible for ischemic type biliary lesions. Due to low viscosity, HTK solution is reported to have a lower incidence of biliary complications. However, there is no data concerning ischemic type biliary lesions in HTK preserved livers. In this paper we report our results after orthotopic liver transplantation with special regard to ischemic type biliary lesions in …
Genetic influences on resting electrocardiographic variables in older women: a twin study.
2009
Background: Previous studies in young and middle-aged men and women have shown that resting electrocardiographic (ECG) variables are influenced by genetic factors. However, the extent to which resting ECG variables are influenced by genetic factors in older women is unknown. Thus, the aim of this study was to estimate the relative contribution of genetic and environmental influences to individual differences in resting ECG variables among older female twins without overt cardiac diseases. Methods: Resting ECG recordings were obtained from 186 monozygotic and 203 dizygotic twin individuals, aged 63–76 years. Quantitative genetic modeling was used to decompose the phenotypic variance in each …
High-Sensitivity Procalcitonin (hs-PCT): A Marker for Identification of Arteriosclerosis and Myocardial Infarction?
2008
Background: Procalcitonin (PCT) is a protein hormone induced by bacterial inflammation that serves as a marker of sepsis. C-reactive protein (CRP) is also known to be a marker of inflammation and, in low concentrations, a prognostic marker for latent or early arteriosclerosis. Arteriosclerosis is considered as an inflammatory process that begins in the wall of an artery. In addition to CRP, the concentration of other markers of inflammation increases in the presence of arteriosclerosis. Methods: To determine if PCT is among these markers, the serum concentration of PCT was quantified in blood samples from healthy individuals (n = 410) and at admission in 774 patients, 92 with peripheral art…
Autonomic dysfunction in a group of lower extremities arterial disease outpatients.
2021
Background: The understanding of the specific role of sympathetic neural control and dysregulation in lower extremities arterial disease (LEAD) is still very limited. Aim of our study was to investigate the autonomic profile in LEAD patients and to evaluate if the eventual autonomic alterations were more severe in patients with advanced disease. Methods: We enrolled all consecutive outpatients with LEAD referred to our Departments between July 2012 and September 2014. They were compared to a group of matched outpatients without LEAD. All patients underwent Holter ECG monitoring. Time-domain analysis of heart rate variability (HRV) was evaluated. Results: Compared to controls, patients with …
The effect of two sulphur-containing pesticides, fenitrothion and endosulfan, on glutathione (GSH) content and on GSH S-transferase and gamma-glutamy…
1988
The glutathione (GSH) system of Procambarus clarkii (P.c.), the American red crayfish, is used as a marker of the effects of Fenitrothion (FT) and Endosulfan (ES), organophosphorus and organochlorinated insecticides, respectively. This system has been shown to be sensitive to different heavy metals poisoning, thus it has a double interest as marker for environmental contamination and as a potential source of xenobiotics or their metabolites to humans, since it is being fished commercially. The GSH content of the organ decreased 24 h after treatment with FT. FT promotes a 2-fold induction of GSH S-transferase (GST) activity at 6 h which is followed by a decrease of it at 24 h. The latter coi…
Ventricular Fibrillation detection using time-frequency and the KNN classifier without parameter extraction
2017
[ES] Este trabajo propone la detección de FV y su discriminación de TV y otros ritmos cardiacos basándose en la representación tiempo-frecuencia del ECG y su conversión en imágen como entrada a un clasificador de vecinos más cercanos (KNN) sin necesidad de extracción de parámetros adicionales. Tres variantes de datos de entrada al clasificador son evaluados. Los resultados clasifican la señal en cuatro clases diferentes: ’Normal’ para latidos con ritmo sinusal, ’FV’ para fibrilación ventricular, ’TV’ para taquicardia ventricular y ’Otros’ para el resto de ritmos. Los resultados para detección de FV mostraron 88,27% de sensibilidad y 98,22% de especificidad para la entrada de imágen equivale…
Severe Tremor After Cotrimoxazole-Induced Elevation of Venlafaxine Serum Concentrations in a Patient With Major Depressive Disorder
2013
: We describe a female patient who was an extensive metabolizer of cytochrome P450 isoenzyme (CYP) 2D6 and an intermediate metabolizer of CYP2C19 (genotype: CYP2C19 *1/*2). She exhibited high serum concentrations of venlafaxine and O-desmethylvenlafaxine and developed severe tremor after comedication with cotrimoxazole (sulfamethazole/trimethoprim). Venlafaxine is mainly metabolized by O- and N-demethylation. O-demethylation is catalyzed by the highly polymorphic CYP2D6 and N-demethylation by several enzymes, CYP2C19, CYP2C9, and CYP3A4. The observed overall pharmacokinetic effect was most probably the result of decreased N-demethylation of venlafaxine by (1) reduced expression of CYP2C19 d…
Dofetilide effects on the inhibition by trains of subthreshold conditioning stimuli.
2004
We investigated the electrophysiological actions of dofetilide upon the ventricular myocardium to determine whether the drug modifies the inhibitory effects of subthreshold stimuli trains upon ventricular refractoriness. In nine Langendorff perfused rabbit hearts, ventricular epicardial electrodes were used to determine the following parameters at baseline and during dofetilide perfusion (0.5 micromolar): effective (ERP) and functional (FRP) refractory periods, conduction velocity (CV), wavelength (WL), and ERP prolongation (inhibitory effect) induced by subthreshold stimuli trains (STr) at pulse frequencies of 100, 300, and 600 Hz. Dofetilide significantly prolongs ventricular refractorine…
The Role of Cardiac Pacing in Heart Block Complicating Acute Myocardial Infarction
1983
The organization of the Coronary Care Unit and the use of electrocardiographic monitoring have allowed a re-evaluation of the incidence of the atrioventricular conduction disturbances in acute myocardial infarction.
Are double potentials markers of a specific zone of the atrioventricular junction in the isolated rabbit heart?
1997
A study is made of the characteristics of the atrial potentials recorded in the Koch triangle and its proximity, their variations on modifying the site of cardiac pacing, and their usefulness as markers of a distinct zone of the AV junction. In 12 isolated and perfused rabbit heart preparations an analysis was made of the endocardial atrial electrograms recorded with a multiple electrode positioned in the AV junction. The electrograms were obtained during spontaneous rhythm and on pacing at the crista terminalis (CT), interatrial septum (IAS), left atrium, and right ventricle. Double potentials were frequently obtained. On pacing at the CT, high-low double potentials (DP [H-L]) were more fr…