Search results for "Role"

Erste Erfahrungen mit Amisulprid, einem in Deutschland neuen, atypischen Neuroleptikum in der Behandlung von Jugendlichen mit psychischen Erkrankungen

2001

Zusammenfassung: Fragestellung: Neben den klassischen Neuroleptika finden bei Jugendlichen zunehmend atypische Neuroleptika zur Behandlung schizophrener und schizoaffektiver Psychosen Verwendung. Seit Beginn des Jahres 1999 ist in Deutschland in der Behandlung akuter schizophrener Psychosen ein neues, offensichtlich wirkungsvolles Neuroleptikum aus der Gruppe der Benzamide verfügbar: Amisulprid. Erste Erfahrungen mit der Anwendung von Amisulprid werden berichtet. Methode: Zehn gut dokumentierte Behandlungsverläufe bei Jugendlichen unter Behandlung mit Amisulprid werden hinsichtlich Effektivität, unerwünschter Wirkungen und Dosierung berichtet. Ergebnisse: Erste Erfahrungen im Einsatz von Am…

Therapeutic options for homozygous familial hypercholesterolemia: the role of Lomitapide

2020

Background:Lomitapide (Juxtapid® in US and Lojuxta® in Europe) is the first developed inhibitor of the Microsomal Triglyceride Transfer Protein (MTP) approved as a novel drug for the management of Homozygous Familial Hypercholesterolemia (HoFH). It acts by binding directly and selectively to MTP thus decreasing the assembly and secretion of the apo-B containing lipoproteins both in the liver and in the intestine.Aims:The present review aims at summarizing the recent knowledge on lomitapide in the management of HoFH.Results:The efficacy and safety of lomitapide have been evaluated in several trials and it has been shown a reduction of the plasma levels of Low-Density Lipoprotein Cholesterol …

Lomitapide does not alter PCSK9 and Lp(a) levels in homozygous familial hypercholesterolemia patients: analysis on cytokines and lipid profile

2021

Abstract Lomitapide, a drug for the treatment of homozygous familial hypercholesterolemia patients, reduced total and LDL cholesterol but no significant changes were observed on PCSK9 and Lp(a) plasma levels. Some changes of inflammatory mediators were also observed, including hsCRP, which may suggest an anti-inflammatory effect.

Amorphous Ropinirole-Loaded Mucoadhesive Buccal Film: A Potential Patient-Friendly Tool to Improve Drug Pharmacokinetic Profile and Effectiveness

2020

Nowadays the therapeutic strategies to manage Parkinson&rsquo

Highly convergent total synthesis of (+)-anaferine and (−)-dihydrocuscohygrine

2019

A unified and highly convergent total synthesis of anaferine and dihydrocuscohygrine alkaloids has been devised, taking advantage of the dual role of N-sulfinyl amines as nucleophilic nitrogen sources and chiral auxiliaries. A bidirectional cross metathesis reaction followed by a double intramolecular aza-Michael reaction led us to create the whole skeleton of the natural products in a very simple manner.

Dual Role of Vinyl Sulfonamides as N -Nucleophiles and Michael Acceptors in the Enantioselective Synthesis of Bicyclic δ-Sultams

2018

Motor decision and modular control of an hyper-redundant system

2015

This thesis is aimed at better understanding how the Central Nervous System (CNS) plans and controls voluntary movements. When moving, humans must overcome intrinsic (e.g. choosing which muscles to activate) and extrinsic (e.g. choosing where to reach an object) redundancy, requiring selecting one motor solution among several potential ones. To better understand this process, we studied in parallel two important motor control theories: muscular synergies and motor decision. In a first part, we focused on intrinsic redundancy by testing the muscular synergies hypothesis. According to it, the CNS simplifies the control of muscles, in using a limited set of building blocks whose linear combina…

Language Mediation and Aspects of Accommodation in the Use of ELF

2014

There are numerous varieties of English spoken in Italy today, each repre-sented by one or more of the various migrant communities living in the country. These manifestations of World englishes reflect a wide range of lexical, syntactical, phonetic, pragmatic, interpersonal and cultural features. This paper argues that an interpreter or language mediator trained in standard English may not necessarily be able to comprehend or make him/herself understood adequately in other varieties of English. Thus, the recruitment of mediators/interpreters requires a certain amount of caution in terms of language choice. In order to investigate intelligibility, comprehensibility and accommodation in the c…

Employees' work patterns-office type fit and the dynamic relationship between flow and performance

2021

Organizations must improve their employees’ performance in order to compete effectively. Evidence shows that flow experiences enhance performance. However, a dynamic approach to this phenomenon is needed. Furthermore, different work patterns (based on task profiles) can have specific environmental requirements (office types). This research aims to analyze the dynamic relationship between office workers’ flow and in‐role and extra‐role performance, considering work pattern–office type fit as a predictor of the initial level of each of these three variables. A total of 83 workers participated in this diary study. Results of the latent growth model showed a positive association between: (1) th…

Helium isotope systematics of volcanic gases and thermal waters of Guadeloupe Island, Lesser Antilles

2014

Abstract The island of Guadeloupe is located in the middle of the 850 km long Lesser Antilles island arc. Present-day volcanic and geothermal activity is concentrated in two systems both located in the southwestern part of the island (Basse Terre): the La Soufriere volcanic complex and the Bouillante hydrothermal system, some 20 km to the northwest of the volcano. We report here the largest isotopic data set for helium isotopes in hydrothermal gases and waters from both systems, acquired between 1980 and 2012. 3 He/ 4 He ratios in the fumarolic gases of La Soufriere volcano have been quite homogeneous and stable over the last thirty years. The average ratio of 8.2 ± 0.2 R a confirms that th…