Search results for "Rome"

The rodent tibia fracture model: A critical review and comparison with the complex regional pain syndrome literature

2018

Abstract Distal limb fracture is the most common cause of complex regional pain syndrome (CRPS), thus the rodent tibia fracture model (TFM) was developed to study CRPS pathogenesis. This comprehensive review summarizes the published TFM research and compares these experimental results with the CRPS literature. The TFM generated spontaneous and evoked pain behaviors, inflammatory symptoms (edema, warmth), and trophic changes (skin thickening, osteoporosis) resembling symptoms in early CRPS. Neuropeptides, inflammatory cytokines, and nerve growth factor (NGF) have been linked to pain behaviors, inflammation, and trophic changes in the TFM model and proliferating keratinocytes were identified …

Cannabidiol Treatment Might Promote Resilience to Cocaine and Methamphetamine Use Disorders: A Review of Possible Mechanisms

2019

Currently, there are no approved pharmacotherapies for addiction to cocaine and other psychostimulant drugs. Several studies have proposed that cannabidiol (CBD) could be a promising treatment for substance use disorders. In the present work, the authors describe the scarce preclinical and human research about the actions of CBD on the effects of stimulant drugs, mainly cocaine and methamphetamine (METH). Additionally, the possible mechanisms underlying the therapeutic potential of CBD on stimulant use disorders are reviewed. CBD has reversed toxicity and seizures induced by cocaine, behavioural sensitization induced by amphetamines, motivation to self-administer cocaine and METH, context- …

Descriptive study on subjective experience of genetic testing with respect to relationship, family planning and psychosocial wellbeing among women wi…

2021

AbstractBackgroundDue to increased risk of endometrial and ovarian cancer, women belonging to known Lynch Syndrome (LS) families are recommended to undergo germline testing. Current practice in Finland is to offer counselling to women with pathogenic variant and advocate risk-reducing surgery (RRS) after completion of childbirth. The present study aimed to clarify the impacts of positive germline testing on family planning and reproductive decisions of these women, which are relatively unknown.MethodsSeventy-nine carriers of germline MMR gene pathogenic variant (path_MMR)were identified from the Finnish LS Registry as having genetic testing performed before the age of 45 years and not havin…

C5a complement and cytokine signaling mediate the pronociceptive effects of complex regional pain syndrome patient IgM in fracture mice.

2020

It has been proposed that complex regional pain syndrome (CRPS) is a posttraumatic autoimmune disease. Previously, we observed that B cells contribute to CRPS-like changes in a mouse tibia fracture model, and that early (12 months duration) CRPS patient IgM antibodies have pronociceptive effects in the skin and spinal cord of muMT fracture mice lacking B cells. The current study evaluated the pronociceptive effects of intraplantar or intrathecal injections of early CRPS IgM (5 µg) in muMT fracture mice. Skin and lumbar spinal cord were collected for immunohistochemistry and polymerase chain reaction analyses. Wild-type mice exhibited postfracture increases in complement component C5a and it…

Castello di Rometta

2001

scheda di catalogo del castello di Rometta

Sistema nervioso central y Síndrome de Down

2005

Se describen las alteraciones en el sistema nervioso central y sus repercusiones en los procesos cognitivos básicos de las personas con Síndrome de Down.

Saint Agnes of Rome, the Pope and the “Purpuresque Pavo”: Memory Issues of the Apse Mosaic of Santa Agnese fuori le mura (625-638)

2018

The theme of memory is at the heart of apse mosaic of Santa Agnese fuori le mura. It’s a visual discourse about a roman martyr linked to the founder of new basilica and the “purpuresque pavo”. With the offering of this mosaics, the pope Honorius honours Saint Agnes’s memory. Honorius reaches to blend in a complex system of commemoration. Some close links are forged between the pope and the roman martyr. A true locus memoriae was established on the Via Nomentana since the middle of the IVth century. In the dedicatory inscription, the “purpuresque pavo” reminds the sacrifice of Christ, the martyrdom of Saint Agnes and the resurrection of the Elect. Thus, Honorius left an indelible mark in Rom…

Ridurre il rischio cardiovascolare nella donna mediante stretto follow-up della sindrome metabolica in menopausa: un obiettivo possibile

2009

European guidelines on chronic mesenteric ischaemia - joint United European Gastroenterology, European Association for Gastroenterology, Endoscopy an…

2020

Chronic mesenteric ischaemia is a severe and incapacitating disease, causing complaints of post-prandial pain, fear of eating and weight loss. Even though chronic mesenteric ischaemia may progress to acute mesenteric ischaemia, chronic mesenteric ischaemia remains an underappreciated and undertreated disease entity. Probable explanations are the lack of knowledge and awareness among physicians and the lack of a gold standard diagnostic test. The underappreciation of this disease results in diagnostic delays, underdiagnosis and undertreating of patients with chronic mesenteric ischaemia, potentially resulting in fatal acute mesenteric ischaemia. This guideline provides a comprehensive overvi…

CCDC 650418: Experimental Crystal Structure Determination

2003

Related Article: Y.Jacquot, B.Refouvelet, O.Blacque, M.M.Kubicki, A.Xicluna|2001|C.R.Acad.Sci.,Ser.IIc:Chim.|4|375|doi:10.1016/S1387-1609(01)01243-9