Search results for "Ronyons"

showing 7 items of 7 documents

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

2016

Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular filtration rate (eGFR), combining data across 133,413 individuals with replication in up to 42,166 individuals. We identify 24 new and confirm 29 previously identified loci. Of these 53 loci, 19 associate with eGFR among individuals with diabetes. Using bioinformatics, we show that identified genes at eGFR loci are enriched for expression in kidney tissues and in pathways relevant for kidney development and transmembrane transporter activity, kidney structure, and regulation o…

0301 basic medicineNephrologyGenetics and Molecular Biology (all)estimated glomerular filtration rateestimated glomerular filtration rate chronic kidney disease genetic determinantsGeneral Physics and AstronomyKidney developmentGenome-wide association studyBiochemistrySettore MED/14 - NEFROLOGIARenal InsufficiencyChronicGeneticsAGEN Consortiumddc:616education.field_of_studyKidneyStage renal-diseaseMultidisciplinaryGenome-wide associationCHARGe-Heart Failure GroupGene Expression Regulation; Genome-Wide Association Study; Genotype; Humans; Renal Insufficiency Chronic; Genetic Predisposition to Disease; Biochemistry Genetics and Molecular Biology (all); Chemistry (all); Physics and Astronomy (all)QChemistry (all)MetaanalysisGene Expression Regulation; Genetic Predisposition to Disease; Genome-Wide Association Study; Genotype; Humans; Renal Insufficiency Chronic/geneticsBiological sciencesSerum creatininemedicine.anatomical_structureEfficientRonyons -- FisiologiaHypertensionICBP ConsortiumTransmembrane transporter activitygenetic association loci kidney functionCARDIOGRAMHumanmedicine.medical_specialtyGenotypeSciencePopulationRenal functionECHOGen ConsortiumReplicationBiologyEnvironmentResearch SupportGeneral Biochemistry Genetics and Molecular BiologyN.I.H.genetic determinants03 medical and health sciencesPhysics and Astronomy (all)GENOME-WIDE ASSOCIATION ; FALSE DISCOVERY RATES ; STAGE RENAL-DISEASE ; SERUM CREATININE ; METAANALYSIS ; VARIANTS ; INDIVIDUALS ; POPULATION ; RISK ; HYPERTENSIONKidney functionResearch Support N.I.H. ExtramuralInternal medicineMD MultidisciplinarymedicineGeneticsJournal ArticleHumanseGFRcrea; eGFRcysGenetic Predisposition to Diseaseddc:610GenetikRenal Insufficiency ChronicMortalityeducationddc:613Biochemistry Genetics and Molecular Biology (all)urogenital systemIndividualsExtramuralGeneral Chemistryta3121medicine.diseaseR1030104 developmental biologyGene Expression RegulationBiochemistry Genetics and Molecular Biology (all); Chemistry (all); Physics and Astronomy (all)570 Life sciences; biologyGenèticachronic kidney diseaseKidney diseaseGenome-Wide Association StudyMeta-Analysis
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Hereditary Leiomyomatosis and Renal Cell Cancer Syndrome in Spain: Clinical and Genetic Characterization

2020

Simple Summary Hereditary leiomyomatosis and renal cell cancer (HLRCC) syndrome is a very rare hereditary disorder characterized by cutaneous leiomyomas (CLMs), uterine leiomyomas (ULMs), renal cysts (RCys) and renal cell cancer (RCC), with no data on its prevalence worldwide. No genotype-phenotype associations have been described. The aim of our study was to describe the genotypic and phenotypic features of the largest series of patients with HLRCC from Spain reported to date. Of 27 FH germline pathogenic variants, 12 were not previously reported in databases. Patients with missense pathogenic variants showed higher frequencies of CLMs, ULMs and RCys, than those with loss-of-function varia…

0301 basic medicineOncologyCancer ResearchCancer cellsmedicine.disease_causeurologic and male genital diseases:Male Urogenital Diseases::Urogenital Neoplasms::Urologic Neoplasms::Kidney Neoplasms::Male Urogenital Diseases::Carcinoma Renal Cell [DISEASES]<i>FH</i> gene0302 clinical medicineMalalties hereditàriesMissense mutationFH geneFH gene hereditary leiomyomatosis leiomyomas missense pathogenic variants renal cell cancerRenal cell cancerMutationKidney diseasesHereditary leiomyomatosis:Otros calificadores::Otros calificadores::/genética [Otros calificadores]:enfermedades urogenitales masculinas::neoplasias urogenitales::neoplasias urológicas::neoplasias renales::enfermedades urogenitales masculinas::carcinoma de células renales [ENFERMEDADES]leiomyomasmissense pathogenic variants renal cell cancerlcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogensRare diseases:Geographic Locations::Europe::Spain [GEOGRAPHICALS]Oncology030220 oncology & carcinogenesisCohortCèl·lules cancerosesMalalties raresRenal Cell CancersGenetic disordersmedicine.medical_specialtyMissense pathogenic variantsBiología Celularlcsh:RC254-282Article03 medical and health sciencesLeiomyomasInternal medicine:Other subheadings::Other subheadings::/genetics [Other subheadings]medicineRonyons - Malalties - Espanya:localizaciones geográficas::Europa (continente)::España [DENOMINACIONES GEOGRÁFICAS]business.industry:neoplasias::neoplasias por tipo histológico::neoplasias de tejido conjuntivo y de tejidos blandos::neoplasias de tejido muscular::leiomioma::leiomiomatosis [ENFERMEDADES]Retrospective cohort studymedicine.diseaseGenética030104 developmental biologyFumaraseClinical diagnosisHereditary leiomyomatosis and renal cell cancer syndromeMalalties del ronyó:Neoplasms::Neoplasms by Histologic Type::Neoplasms Connective and Soft Tissue::Neoplasms Muscle Tissue::Leiomyoma::Leiomyomatosis [DISEASES]hereditary leiomyomatosisbusiness
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Consenso Delphi sobre el diagnóstico y manejo de la dislipidemia en pacientes con enfermedad renal crónica: análisis post-hoc del estudio DIANA

2016

Resumen Antecedentes y objetivos: Este estudio post hoc analizó la percepción de la importancia de la enfermedad renal crónica (ERC) en el cribado de la dislipidemia y en la elección del tratamiento con estatinas entre médicos de Atención Primaria (MAP) y otras especialidades mediante cuestionario Delphi. Métodos: El cuestionario incluyó 4 bloques de preguntas alrededor del paciente dislipémico con alteración del metabolismo hidrocarbonado. Aquí se presentan los resultados relacionados con la consideración de la ERC en el cribado y la elección de la estatina. Resultados: De los 497 expertos incluidos, el 58% eran MAP y el 42%, especialistas (35, el 7%, nefrólogos). Hubo consenso en realizar…

DyslipidaemiaPulmons -- Malalties obstructivesRiesgo cardiovascularDelphi Technique030204 cardiovascular system & hematologylcsh:RC870-923urologic and male genital diseases0302 clinical medicineRisk FactorsSurveys and QuestionnairesChronic kidney diseaseMedicine030212 general & internal medicinecomputer.programming_languagemedicine.diagnostic_testLipidsfemale genital diseases and pregnancy complicationsCardiovascular DiseasesNephrologylipids (amino acids peptides and proteins)medicine.symptomEstatinasGlomerular Filtration Ratemedicine.medical_specialtyConsensusStatinRonyons -- Malaltiesmedicine.drug_classRenal function03 medical and health sciencesInternal medicineDislipidemiaPost-hoc analysisAlbuminuriaHumansRenal Insufficiency ChronicIntensive care medicineEnfermedad renal crónicaDyslipidemiasbusiness.industryStatinsnutritional and metabolic diseasesGuidelineCardiovascular risklcsh:Diseases of the genitourinary system. Urologymedicine.diseaseEndocrinologyAlbuminuriabusinessLipid profilecomputerDelphiKidney diseaseNefrología (English Edition)
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Risk factors for non-melanoma skin cancer in kidney transplant patients in a Spanish population in the Mediterranean region.

2013

Non-melanoma skin cancer (NMSC) is the most frequent malignancy in organ transplant recipients. The aetiology of NMSC after transplant is multifactorial. The aim of this study was to determine the clinical and environmental factors involved in the development of NMSC in a Spanish kidney transplant population from the Mediterranean region. A total of 289 patients who had received a kidney transplant during the period January 1996 to December 2010 were included in the study. Both prospective and retrospective data were used. All patients underwent a structured interview and a complete examination of the skin. After a median follow-up of 72 months (range 12-180 months), 73 of the 289 patients …

MaleSkin NeoplasmsTime FactorsBiopsyKaplan-Meier EstimateOrgan transplantationRisk FactorsSurveys and QuestionnairesCumulative incidenceProspective StudiesCàncerProspective cohort studyeducation.field_of_studyMediterranean RegionIncidence (epidemiology)IncidenceAge FactorsPellGeneral MedicineMiddle AgedDermatologiaCarcinoma Squamous CellSunlightFemaleImmunosuppressive AgentsAdultmedicine.medical_specialtyAdolescentPopulationDermatologyRisk AssessmentNefrologiaYoung AdultInternal medicineOccupational ExposuremedicineHumanseducationAgedProportional Hazards ModelsRetrospective StudiesRonyonsbusiness.industryRetrospective cohort studymedicine.diseaseKidney TransplantationSurgeryTransplantationCarcinoma Basal CellSpainMultivariate AnalysisSkin cancerbusinessPrecancerous ConditionsActa dermato-venereologica
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Cura de la piedra y dolor de la yjada y colica rreñal

1498

Sign.: [2]a6-n6, o4, p4. - Data completa, 4 abril, 1498 L. gòt. - 2 mides. - 2 col. - 40 lín. - Min. p. inic. - Llegendes de foli. - Filigr.: mà i estel. - Numerats els f. I-LXXXV. - Capll. grav

Ronyons Malalties Obres anteriors al 1800Urologia Obres anteriors al 1800
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SGLT2i and GLP-1RA in Cardiometabolic and Renal Diseases: From Glycemic Control to Adipose Tissue Inflammation and Senescence

2021

Background. Over the last few years, the use of sodium-glucose cotransporter 2 inhibitors (SGLT2i) and glucagon-like peptide 1 receptor agonists (GLP-1RA) has increased substantially in medical practice due to their documented benefits in cardiorenal and metabolic health. In this sense, and in addition to being used for glycemic control in diabetic patients, these drugs also have other favorable effects such as weight loss and lowering blood pressure, and more recently, they have been shown to have cardio and renoprotective effects with anti-inflammatory properties. Concerning the latter, the individual or associated use of these antihyperglycemic agents has been linked with a decrease in p…

SenescenceEndocrinology Diabetes and MetabolismAdipose tissueInflammationGlycemic ControlReview ArticleDiseaseBioinformaticsDiseases of the endocrine glands. Clinical endocrinologyGlucagon-Like Peptide-1 ReceptorProinflammatory cytokineEndocrinologySodium-glucose cotransporter 2 inhibitors (SGLT2i)Weight lossDiabetes mellitusmedicineHumansSodium-Glucose Transporter 2 InhibitorsCellular SenescenceGlycemicInflammationMetabolic SyndromeManagement of diabetesRonyonsDiabetisbusiness.industryRC648-665medicine.diseaseCor MalaltiesAdipose TissueantihyperglycemicPatients obesity and cardiorenal compromiseglycemic controlmedicine.symptombusinessGlucagon-like peptide 1 receptor agonists (GLP-1RA)
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Cura de la piedra y dolor de la ijada / [Julián Gutiérrez

1498

Sign.: [2]a6-n6, o4, p4. - Data completa, 4 abril, 1498 L. gòt. - 2 mides. - 2 col. - 40 lín. - Min. p. inic. - Llegendes de foli. - Filigr.: mà i estel. - Numerats els f. I-LXXXV. - Capll. grav.

Urologia Obres anteriors a 1800Ronyons Malalties Obres anteriors a 1800DIG-BH
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