Search results for "Roos"
showing 10 items of 58 documents
Opettajien ja oppilaiden mielipiteitä Rolling Bones -projektin liikuntatunneista
2001
Maailman ensimmäinen nainen - Eleanor Rooseveltin roolin ja kirjoitusten poliittisuus My Day - kolumneissa 1936-1941
2013
1930-luvun taitteessa puhjennut maailmanlaajuinen lama koetteli erityisen ankarasti Yhdysvaltoja ja leimasi maan kehitystä toisen maailmansodan puhkeamiseen asti. Franklin Roosevelt toimi maan presidenttinä vuosina 1933–1945 ja pyrki parantamaan ihmisten elinoloja sosiaalipoliittisella New Deal - ohjelmallaan. Hänen rinnallaan julkisuudessa ja myös poliittisen vaikuttamisen kulisseissa toimi hänen vaimonsa Eleanor Roosevelt, joka uudisti maan ensimmäisen naisen roolia aktiivisuudellaan. Tässä tutkielmassa tarkastellaan Eleanor Rooseveltin poliittista vaikutusvaltaa vuosina 1936–1941 hänen kirjoittamansa My Day – kolumnin kautta. Kolumnisteilla oli 1930-luvulla merkittävä rooli yhdysvaltalai…
Muscle and bone mass in middle‐aged women : role of menopausal status and physical activity
2020
Background. Women experience drastic hormonal changes during midlife due to the menopausal transition. Menopausal hormonal changes are known to lead to bone loss and potentially also to loss of lean mass. The loss of muscle and bone tissue coincide due to the functional relationship and interaction between these tissues. If and how physical activity counteracts deterioration in muscle and bone during the menopausal transition remains partly unresolved. This study investigated differences between premenopausal, early perimenopausal, late perimenopausal, and postmenopausal women in appendicular lean mass (ALM), appendicular lean mass index (ALMI), femoral neck bone mineral density (BMD) and T…
Physical Methods for Enhancing Oral Mucosal Delivery: Sonophoresis, Iontophoresis and Electroporation
2015
The need for more rapid onset of action and improved absorption of medications has resulted in great development of drug delivery technologies. Transmucosal drug delivery offers a convenient route of administration for a variety of clinical indications. Unfortunately, the wide variability in structure of the oral mucosal tissues could constitute a key factor in drug penetration and absorption. To circumvent this obstacle and to increase the drug flux through the mucosal membranes, different approaches to permeation enhancement are used. This chapter describes the most significant aspects of the physical techniques widely used such as sonophoresis, iontophoresis, and electroporation. These p…
Nuclear microscopy : development and applications in atherosclerosis, Parkinson's disease and matherials physics
2007
Succinobucol's New Coat - Conjugation with Steroids to Alter Its Drug Effect and Bioavailability
2011
Synthesis, detailed structural characterization (X-ray, NMR, MS, IR, elemental analysis), and studies of toxicity, antioxidant activity and bioavailability of unique potent anti-atherosclerotic succinobucol-steroid conjugates are reported. The conjugates consist of, on one side, the therapeutically important drug succinobucol ([4-{2,6-di-tert-butyl-4-[(1-{[3-tert-butyl-4-hydroxy-5-(propan-2-yl)phenyl]sulfanyl}ethyl)sulfanyl]phenoxy}-4-oxo-butanoic acid]) possessing an antioxidant and anti-inflammatory activity, and on the other side, plant stanol/sterols (stigmastanol, β-sitosterol and stigmasterol) possessing an ability to lower the blood cholesterol level. A cholesterol-succinobucol prodr…
Metaboliitit voivat selittää liikuntaharrastuksen verisuonivaikutuksia
2022
Chip for dielectrophoretic microbial capture, separation and detection II: experimental study
2023
Abstract In our previous paper we have modelled a dielectrophoretic force (DEP) and cell particle behavior in a microfluidic channel (Weber MU et al 2023 Chip for dielectrophoretic microbial capture, separation and detection I: theoretical basis of electrode design Nanotechnology this issue). Here we test and confirm the results of our modeling work by experimentally validating the theoretical design constraints of the ring electrode architecture. We have compared and tested the geometry and particle capture and separation performance of the two separate electrode designs (the ring and dot electrode structures) by investigating bacterial motion in response to the applied electric field. We …
Opposing health effects of hybridization for conservation
2021
The continuing decline of many natural plant and animal populations emphasizes the importance of conservation strategies. Hybridization as a management tool has proven successful in introducing gene flow to small, inbred populations, but can be also associated with health risks. For example, hybridization can change susceptibility to infection in either direction due to heterosis (hybrid vigor) and outbreeding depression, but such health effects have rarely been considered in the genetic management of populations. Here, we investigated the effects of experimental outcrossing between the critically endangered Saimaa landlocked salmon (Salmo salar m. sebago) and the genetically more diverse A…