Search results for "Rootletin"

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Roles for ELMOD2 and Rootletin in ciliogenesis.

2021

AbstractELMOD2 is a GTPase activating protein (GAP) with uniquely broad specificity for ARF family GTPases. We previously showed that it acts with ARL2 in mitochondrial fusion and microtubule stability and with ARF6 during cytokinesis. Mouse embryonic fibroblasts deleted for ELMOD2 also displayed changes in cilia related processes including increased ciliation, multiciliation, ciliary morphology, ciliary signaling, centrin accumulation inside cilia, and loss of rootlets at centrosomes with loss of centrosome cohesion. Increasing ARL2 activity or overexpressing Rootletin reversed these defects, revealing close functional links between the three proteins. This was further supported by the fin…

GTPase-activating proteinBiologyMicrotubulesMitochondrial DynamicsCell Line03 medical and health sciencesMice0302 clinical medicineMicrotubuleGTP-Binding ProteinsCiliogenesisAnimalsHumansCiliaMolecular Biology030304 developmental biologyCytokinesisCentrosome0303 health sciencesADP-Ribosylation FactorsCiliumGTPase-Activating ProteinsCell BiologyArticlesFibroblastsCell biologyMitochondriaCytoskeletal Proteinsmitochondrial fusionCentrosomeCentrinRootletin030217 neurology & neurosurgeryCytokinesisSignal TransductionMolecular biology of the cell

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