Search results for "Roth"

Experimental evolution of an oncolytic vesicular stomatitis virus with increased selectivity for p53-deficient cells

2014

Experimental evolution has been used for various biotechnological applications including protein and microbial cell engineering, but less commonly in the field of oncolytic virotherapy. Here, we sought to adapt a rapidly evolving RNA virus to cells deficient for the tumor suppressor gene p53, a hallmark of cancer cells. To achieve this goal, we established four independent evolution lines of the vesicular stomatitis virus (VSV) in p53-knockout mouse embryonic fibroblasts (p53-/- MEFs) under conditions favoring the action of natural selection. We found that some evolved viruses showed increased fitness and cytotoxicity in p53-/- cells but not in isogenic p53+/+ cells, indicating gene-specifi…

Basic Notions of the Theory of Heat

2016

This chapter summarizes some basic notions of thermodynamics and defines the empirical variables which are needed for the description of thermodynamic systems in equilibrium. Empirical temperature and several scales used to measure temperature are defined. The so-called “zeroth law of thermodynamics” is formulated which says that systems which are in mutual equilibrium have the same temperature. Thermodynamic ensembles corresponding to different macroscopic boundary conditions are introduced and are illustrated by simple models such as the ideal gas. Also, entropy appears on the scene for a first time, both in its statistical and its thermodynamical interpretation. Gibb’s fundamental form i…

PROPERTIES OF IONIZING RADIATION CURED POLYMER MATRICES FOR CARBON FIBER COMPOSITES AFTER AGEING DUE TO MOISTURE ABSORPTION AND THERMAL TREATMENT

2008

Idrothermal ageing of ionizing radiation cured epoxy matrices for carbon fibre composites

2008

Response and Recovery of Brain Acetylcholinesterase Activity in the European Eel,Anguilla anguilla,Exposed to Fenitrothion

1998

European eel (Anguilla anguilla) were exposed to sublethal fenitrothion concentrations in a continuous flow-through system for 4 days. Brain acetylcholinesterase (AChE) activity was evaluated after 2, 8, 12, 24, 32, 48, 56, 72, and 96 h pesticide exposure. Results indicated that AChE activity in eel brains decreased as the concentration of fenitrothion increased. The pesticide induced significant inhibitory effects on the AChE activity ofA. anguilla,ranging from >40% inhibition at a sublethal concentration of 0.02 ppm to >60% inhibition at a sublethal concentration of 0.04 ppm. Eel were exposed to both fenitrothion concentrations for 96 h and then allowed a period of recovery in pesticide-f…

THE FRESHWATER CLADOCERA (ORDERS CTENOPODA AND ANOMOPODA) OF MEXICO, WITH COMMENTS ON SELECTED TAXA

1999

AbstractKnowledge of the composition and distribution of the freshwater Cladocera in Mexico is still limited. All the available literature was reviewed and added to our own new records in different states of Mexico to present here a revised and updated list of the 110 species of the orders Ctenopoda and Anomopoda recorded for the country, with separate state records. Ecological, biogeographical, and taxonomic comments are made for selected taxa of the commonest neotropical groups: Sididae, Daphniidae, Bosminidae, Macrothricidae, and Chydoridae. La connaissance de la composition et de la repartition des Cladoceres d'eau douce du Mexique est encore tres limitee. Toute la litterature disponibl…

Time to safely omit bladder cuff removal for low-risk upper tract urothelial carcinoma

2021

Aproximación a las comunidades de carófitos que existieron en la albufera de valencia a partir del estudio de las oósporas del sedimento

2009

14 páginas, 8 figuras, 3 tablas.

Therapeutic Modulation of Urinary Bladder Function: Multiple Targets at Multiple Levels

2015

Storage dysfunction of the urinary bladder, specifically overactive bladder syndrome, is a condition that occurs frequently in the general population. Historically, pathophysiological and treatment concepts related to overactive bladder have focused on smooth muscle cells. Although these are the central effector, numerous anatomic structures are involved in their regulation, including the urothelium, afferent and efferent nerves, and the central nervous system. Each of these structures involves receptors for—and the urothelium itself also releases—many mediators. Moreover, hypoperfusion, hypertrophy, and fibrosis can affect bladder function. Established treatments such as muscarinic antago…

Experimente zur Zeolithbildung durch hydrothermale Umwandlung

1974

The formation of zeolites by hydrothermal alteration has been investigated by taking trass from the Laach volcanic area as a sample. Zeolites to be found are chabazite, phillipsite and analcime, all of which originated from the same phonolitic glass. This paper aims at explaining the formation of zeolites by means of experimental alteration of the pumice with various solutions. NaOH and KOH solutions were used in the experiments, these limited the formation conditions of chabazite, phillipsite, analcime in alkaline environments. Moreover, experiments were carried out with H2O dist and with solutions that formed during the alteration of pumice by reacting with H2O. These experiments were con…