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Projektowane zmiany w regulacji prawnej planowania przestrzennego w Polsce w świetle Europejskiego Zielonego Ładu
2022
Artykuł przedstawia dyskutowane obecnie na świecie zagadnienia związane z pojawieniem się nowych instrumentów mających na celu zapewnienie zrównoważonego rozwoju w kontekście rozważanej obecnie reformy systemu planowania i zagospodarowania przestrzennego w Polsce. W Europie przedmiotem szczególnej uwagi jest wizja nowego paradygmatu rozwoju przewidziana w ramach Europejskiego Zielonego Ładu. Obejmuje on nie tylko kwestie związane z problematyką zmian klimatu (czy szerzej ochrony środowiska) czy też np. tak istotną obecnie samowystarczalność energetyczną Europy, ale też przewiduje konkretne instrumenty służące wdrażaniu nowej wizji rozwoju oraz wskazuje na konieczność rozszerzenia udziału sp…
He kept us out of war? : yleisen mielipiteen vaikutus Woodrow Wilsonin päätöksiin Yhdysvaltain liittymisestä ensimmäiseen maailmansotaan
2003
Pūļa finansēšanas platformas "Projektubanka.lv" komunikācijas novērtējums
2018
Maģistra darba “Pūļa finansēšanas platformas “Projektubanka.lv” komunikācijas novērtējums” mērķis ir noskaidrot, ar kādiem komunikācijas kanāliem tiek uzrunāti projektu autori, un kādas mārketinga stratēģijas, komunikācijas kanālus izmanto projektu autori savām kampaņām, lai piesaistītu ieguldītājus. Maģistra darbs sastāv no teorētiskās literatūras apkopojuma, pētījumā izmantotās metodoloģijas apraksta un pētījuma rezultātu apkopojuma. Pamatojoties uz pētījumā iegūtajiem rezultātiem, darbā tika rastas atbildes uz izvirzītajiem pētnieciskajiem jautājumiem.
Non-crossing quantile regression via monotone B-spline varying coefficients
2019
Quantile regression can be used to obtain a nonparametric estimate of a conditional quantile function. The presence of quantile crossing, however, leads to an invalid distribution of the response and makes it dicult to use the tted model for prediction. In this work, we show that crossing can be alleviated or completely eliminated by explicit modeling of the regression coecients as a function of the percentile values in (0,1). We illustrate the approach via a wellknown dataset by emphasizing dierences with respect to the competitors.
The effects of instructional self-talk on quiet eye duration and golf putting performance
2017
Yonatan Sarig, 2017. The Effects of Instructional Self-Talk on Quiet Eye Duration and Performance. Faculty of Sports and Health Science. University of Jyväskylä. Master’s thesis, 63p. While the literature on the effects of instructional self-talk is comprehensive, a somewhat under-investigated subject is the underlying mechanisms of instructional self-talk. As of late, the trend has been shifted towards researching what are the motivational and attentional constructs at the base of self-talk. Potentially, one such attentional construct is the quiet eye; the final gaze fixation on a target before the execution of task-oriented movement. Since the duration of the quiet eye is found to be asso…
The reactivity of neonatal rabbits to the mammary pheromone as a probe for viability
2012
International audience; Newborn rabbits depend on a daily nursing interaction with the mother to gain milk and to survive. During this interaction, they localise and seize the nipples displaying a typical behaviour triggered by maternal odour cues. The mammary pheromone constitutes such a signal in domestic rabbits: it elicits sucking-related movements in more than 90% of the pups. However, some newborns remain unresponsive to the presentation of the pheromone, even pups apparently healthy and highly motivated to suck. The main goal of the present study was therefore to explore the link between the unresponsiveness of rabbit pups to the mammary pheromone and their growth and survival in bre…
Inhibition of Rac1 signaling by lovastatin protects against anthracycline-induced cardiac toxicity
2011
Normal tissue damage limits the efficacy of anticancer therapy. For anthracyclines, the clinically most relevant adverse effect is cardiotoxicity. The mechanisms involved are poorly understood and putative cardioprotectants are controversially discussed. Here, we show that the lipid-lowering drug lovastatin protects rat H9c2 cardiomyoblasts from doxorubicin in vitro. Protection by lovastatin is related to inhibition of the Ras-homologous GTPase Rac1. It rests on a reduced formation of DNA double-strand breaks, resulting from the inhibition of topoisomerase II by doxorubicin. Doxorubicin transport and reactive oxygen species are not involved. Protection by lovastatin was confirmed in vivo. I…
Tiam1 as a Signaling Mediator of Nerve Growth Factor-Dependent Neurite Outgrowth
2010
Nerve Growth Factor (NGF)-induced neuronal differentiation requires the activation of members of the Rho family of small GTPases. However, the molecular mechanisms through which NGF regulates cytoskeletal changes and neurite outgrowth are not totally understood. In this work, we identify the Rac1-specific guanine exchange factor (GEF) Tiam1 as a novel mediator of NGF/TrkA-dependent neurite elongation. In particular, we report that knockdown of Tiam1 causes a significant reduction in Rac1 activity and neurite outgrowth induced by NGF. Physical interaction between Tiam1 and active Ras (Ras- GTP), but not tyrosine phosphorylation of Tiam1, plays a central role in Rac1 activation by NGF. In add…
Rationale and design of the DARWIN-T2D (DApagliflozin Real World evIdeNce in Type 2 Diabetes): A multicenter retrospective nationwide Italian study a…
2017
Background Randomized controlled trials (RCTs) in the field of diabetes have limitations inherent to the fact that design, setting, and patient characteristics may be poorly transferrable to clinical practice. Thus, evidence from studies using routinely accumulated clinical data are increasingly valued. Aims We herein describe rationale and design of the DARWIN-T2D (DApagliflozin Real World evIdeNce in Type 2 Diabetes), a multicenter retrospective nationwide study conducted at 50 specialist outpatient clinics in Italy and promoted by the Italian Diabetes Society. Data synthesis The primary objective of the study is to describe the baseline clinical characteristics (particularly HbA1c) of pa…
Trait-specific tracking and determinants of body composition: a 7-year follow-up study of pubertal growth in girls
2009
BACKGROUND: Understanding how bone (BM), lean (LM) and fat mass (FM) develop through childhood, puberty and adolescence is vital since it holds key information regarding current and future health. Our study aimed to determine how BM, LM and FM track from prepuberty to early adulthood in girls and what factors are associated with intra- and inter-individual variation in these three tissues. METHODS: The study was a 7-year longitudinal cohort study. BM, LM and FM measured using dual-energy X-ray absorptiometry, self-reported dietary information, leisure time physical activity (LTPA) and other factors were assessed one to eight times in 396 girls aged 10 to 13 years (baseline), and in 255 moth…