Search results for "Rutin"
showing 10 items of 118 documents
Facebookland: o mundo bizarro-linguístico
2019
Abstract This article investigates the dynamics of contemporary Romanian, focusing on various linguistic structures typically used on social network sites, through which the specific content and interaction strategies are being deployed in virtual communities. The article is part of a larger project devoted to the study of linguistic impoverishment (affecting both the vocabulary and the grammatical structure of the language), social networks being only one of the areas where these “uglified” linguistic structures come from: the mass-media (both print and broadcast), advertising (outdoor, indoor, television commercials), Internet forums, corporate jargon, etc. The structures under scrutiny a…
Cortesía verbal y competencia lingüística : la petición cortés como tradición discursiva
2017
Muchas técnicas de atenuación lingüística están estrechamente ligadas a estrategias de cortesía verbal. Un clásico en este contexto son las preguntas del tipo ¿Puedes pasarme el pan, por favor? que funcionan como petición cortés. La cuestión central es cómo esta conocida técnica de la petición cortés puede ser situada en el sistema de la competencia lingüística según Eugenio Coseriu. Resulta preciso aclarar si se trata de tradiciones idiomáticas que pertenecen al saber lingüístico o si se trata de una tradición discursiva y cultural que se realiza en una o varias lenguas, pero que no forma parte de estas lenguas. En el campo de la atenuación lingüística y de la cortesía verbal esta diferenc…
Ibrutinib versus temsirolimus in patients with relapsed or refractory mantle-cell lymphoma : an international, randomised, open-label, phase 3 study
2016
Mantle-cell lymphoma is an aggressive B-cell lymphoma with a poor prognosis. Both ibrutinib and temsirolimus have shown single-agent activity in patients with relapsed or refractory mantle-cell lymphoma. We undertook a phase 3 study to assess the efficacy and safety of ibrutinib versus temsirolimus in relapsed or refractory mantle-cell lymphoma.This randomised, open-label, multicentre, phase 3 clinical trial enrolled patients with relapsed or refractory mantle-cell lymphoma confirmed by central pathology in 21 countries who had received one or more rituximab-containing treatments. Patients were stratified by previous therapy and simplified mantle-cell lymphoma international prognostic index…
Hepatoprotective and anti-inflammatory effects of total flavonoids of Qu Zhi Ke (peel of Citrus changshan-huyou) on non-alcoholic fatty liver disease…
2019
Abstract Background Citrus flavonoids, consisting of naringin, narirutin, neohesperidine, etc., have therapeutic activities for the treatment of lipometabolic disorders. The peel of Citrus changshan-huyou (Qu Zhi Ke, QZK) is a new source of flavonoids, but attracted little attention so far. Hypothesis QZK should possess therapeutic effects against lipometabolic disorders due to the flavonoids it contains. Study design In this study, we extracted and purified the flavonoids of QZK (TFCH) and established an obesity-induced non-alcoholic fatty liver disease (NAFLD) model of rats. TFCH was given orally for 8 weeks, and its anti-NAFLD effects and potential mechanism were evaluated. Methods The f…
Baseline Characteristics Predicting Very Good Outcome of Allogeneic Hematopoietic Cell Transplantation in Young Patients With High Cytogenetic Risk C…
2017
Patients with chronic lymphocytic leukemia with del(17p) or del(11q) have poor long-term prognosis with targeted therapies. Conversely, this retrospective European Society for Blood and Marrow Transplantation registry study shows that young high cytogenetic risk responsive patients with human leukocyte antigen-matched donors have a high 8-year progression-free survival and low 2-year non-relapse mortality after allogeneic stem cell transplantation. This treatment then may compare favorably with targeted therapies for younger high cytogenetic risk patients.Background: Patients with genetically high-risk relapsed/refractory chronic lymphocytic leukemia have shorter median progression-free sur…
Evaluating the (Your Country Here) Olympic Medal Count
2013
An Olympic Games is a measurable test of a nation´s sporting power. Medal counts are the object of intense scrutiny after every Olympiad. Most countries celebrate any medal with national glee, since 60% of competing countries will win none. In 2012, 10% of the competing countries won 75% of all medals. Despite this concentration among a few countries, more countries are winning more medals now than 20 years ago, thanks in part to athlete-support and -development programs arising around the globe. Small strong sporting countries like Norway are typified by fairly large variation in medal results from Olympiad to Olympiad and a high concentration of results in a few sports. These are importan…
Polyphenols of the Mediterranean Diet and Their Metabolites in the Prevention of Colorectal Cancer.
2021
The Mediterranean diet is a central element of a healthy lifestyle, where polyphenols play a key role due to their anti-oxidant properties, and for some of them, as nutripharmacological compounds capable of preventing a number of diseases, including cancer. Due to the high prevalence of intestinal cancer (ranking second in causing morbidity and mortality), this review is focused on the beneficial effects of selected dietary phytophenols, largely present in Mediterranean cooking: apigenin, curcumin, epigallocatechin gallate, quercetin-rutine, and resveratrol. The role of the Mediterranean diet in the prevention of colorectal cancer and future perspectives are discussed in terms of food polyp…
Les partis politiques et la représentation proportionnelle.
2015
International audience; Depuis l’avènement de la Cinquième République, la revendication en faveur de la représentation proportionnelle (RP) - pour la désignation des députés - a été récurrente, et même quasi-unanime, de la part des formations d’opposition ou minoritaires : la RP apparaît comme la promesse de disposer de positions institutionnelles et de participer – s’agissant des élections législatives – au jeu parlementaire. Même le candidat du parti dominant, Nicolas Sarkozy, admettait en 2007 « la possibilité d'introduire un peu de proportionnelle au Sénat ou à l'Assemblée nationale sans créer le risque d'une instabilité qui serait désastreuse. » Aujourd’hui encore, la plupart des forma…
Modulation of drug transport by selected flavonoids: Involvement of P-gp and OCT?
2004
Flavonoids, as a common component of daily nutrition, are a possible source of interference with absorption processes, due to modulation of transporting proteins. In this study, the influence of selected flavonoids (quercetin, isoquercitrin, spiraeoside, rutin, kaempferol, naringenin, naringin, and kaempferol) on the transport of the P-gp substrate [3H]talinolol across Caco-2 cell monolayers was investigated. To elucidate the mechanism behind the interaction observed in this system the potency of the flavonoids to replace [3H]talinolol from its P-gp binding site as well as their activity to inhibit OCT2-mediated [14C]TEA uptake into LLC-PK(1) cells were measured, as P-gp and OCT have been s…
Electrochemical tomato (Solanum lycopersicum L.) characterisation using contact probe in situ voltammetr
2015
[EN] An in situ electrochemical contact probe methodology for characterising tomato samples is proposed. It is based on the record of the voltammetric response of antioxidant compounds when glassy carbon electrodes are inserted into the pericarp of fresh tomato specimens cut in half. The absence of pretreatment and in situ sampling avoid sample contamination and the oxidation of air-sensitive compounds thus increasing the representativity of the analytical data relative to conventional electrochemical analysis. Characteristic voltammetric responses recorded for such compounds, including rutin, chlorogenic acid, naringenin, naringenin chalcone and ascorbic acid have been obtained. A positive…