Search results for "RyR"

showing 10 items of 19 documents

Evaluation of the RYR1 gene genetic diversity in the Latvian White pig breed

2016

The ryanodine receptor 1 (RYR1) is a calcium ion channel in the sarcoplasmic reticulum of skeletal muscle. Multiple polymorphic loci have been identified in the RYR1 gene in human and animals and some of them are associated with certain phenotypes. However, there are still few data on the RYR1 genetic variability in pig and only the missense mutation Arg615Cys, associated with the malignant hyperthermia, porcine stress syndrome and meat quality, has been studied in several commercial and local breeds. Aim. To genotype the rs344435545 (C1972T, Arg615Cys), rs196953058 (T8434C, Phe2769Leu) and rs323041392 (G12484A, Asp4119Asn) in the Latvian local pig breed Latvian White and to evaluate the ev…

0301 basic medicineGeneticspigGenetic diversityAnimal breedingbiologyQH301-705.5genetic diversityQH426-470biology.organism_classificationGeneral Biochemistry Genetics and Molecular BiologyBreedpolymorphism03 medical and health sciences030104 developmental biologyGenetic variationGenotypeRYR1GeneticsGenomics Transcriptomics and ProteomicsRestriction fragment length polymorphismAlleleBiology (General)Latvian White pigBiopolymers and Cell
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Lean Internal Startups for Software Product Innovation in Large Companies: Enablers and Inhibitors

2018

Context: Startups are disrupting traditional markets and replacing well-established actors with their innovative products.To compete in this age of disruption, large and established companies cannot rely on traditional ways of advancement, which focus on cost efficiency, lead time reduction and quality improvement. Corporate management is now looking for possibilities to innovate like startups. Along with it, the awareness and the use of the Lean startup approach have grown rapidly amongst the software startup community and large companies in recent years. Objective: The aim of this study is to investigate how Lean internal startup facilitates software product innovation in large companies.…

FOS: Computer and information sciencesProcess managementQuality managementlarge companiesProcess (engineering)lean startupmethod-in-actionContext (language use)02 engineering and technologyComputer Science - Computers and SocietyComputer Science - Software EngineeringohjelmistoalaComputers and Society (cs.CY)0502 economics and business0202 electrical engineering electronic engineering information engineeringProduct (category theory)lean internal startupsuuryrityksetta113software product innovationProduct innovationinternal startup05 social sciences020207 software engineeringlean-ajatteluinnovaatiotSoftware Engineering (cs.SE)Conceptual frameworkHardware and ArchitectureBusinessLean startup050203 business & managementSoftwareLead timeInformation Systems
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Sosiaalisen median hyödyntäminen suomalaisissa yksityisen sektorin suuryrityksissä

2014

Työssä tutkittiin suomalaisen yksityisen sektorin suuryritysten suhtautumista sosiaaliseen mediaan ja sosiaalisen median hyödyntämistä. Suhtautumisesta tutkittiin, millaista se on ja miten se on muuttunut viime vuosina. Hyödyntämisestä tutkittiin, millaisia käyttötarkoituksia organisaatioilla on eri sosiaalisen median palveluille, millaisia tavoitteita käytölle on asetettu ja millaisia sääntöjä, ohjeita tai rajoituksiao rganisaatioissa on sosiaalisen median käytölle. Tutkimus toteutettiin laadullisia menetelmiä ja sisällönanalyysejä hyödyntäen. Tutkimusmenetelmänä oli avoin teemahaastattelu ja aineisto hankittiin haastattelemalla kuutta yksityisen sektorin suuren organisaation tiedonantajaa…

Facebookorganisaatioyksityinen sektoriTwittersosiaalinen mediaviestintästrategiatsuuryrityksetpuheviestintäviestintästrategia
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Valvontakapitalismin ensimmäiset vuosikymmenet

2021

Arvio teoksesta: Zuboff, Shoshana. 2019. The Age of Surveillance Capitalism: The Fight for the Future at the New Frontier of Power. Lontoo: Profile Books, 704 s.

H1-99profilointikapitalismiCommunication. Mass mediateknologinen kehitysP87-96Journalism. The periodical press etc.PN4699-5650Social sciences (General)kirja-arvosteluthenkilötiedotyksityisyysasiakastiedotKirja-arviotsuuryrityksetdigitalisaatiovalvontaMedia & viestintä
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Non-IFRS and changes in accounting institutions : Lessons from Nokia

2022

We analyse the lessons learned from Nokia to illustrate the changing focus in accounting and organisational practices that affect the perceptions of relevant accounting work and the key measures of success. In the course of an analysis covering 25 years, the introduction of management accounting innovations was first emphasised regarding managerial relevance but were later replaced by financial accounting emphasis and innovations (e.g. non-IFRS reporting). Our data includes public reports, newspaper articles and 21 interviews made between 1996 and 2019. We present a framework for analysing shifts in the focus of accounting. Our case analysis on changing accounting practices, on shifting pe…

Historykansainväliset yrityksetinstituutiotkansainvälinen tilinpäätöskäytäntöaccountingtilinpäätöslaskentatoimimuutosprimary measuresinstitutionalismiworkAccountingchangeinstitutionssuuryritykset
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Impaired Binding to Junctophilin-2 and Nanostructural Alteration in CPVT Mutation

2021

Rationale: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare disease, manifested by syncope or sudden death in children or young adults under stress conditions. Mutations in the Ca 2+ release channel/RyR2 (type 2 ryanodine receptor) gene account for about 60% of the identified mutations. Recently, we found and described a mutation in RyR2 N-terminal domain, RyR2 R420Q . Objective: To determine the arrhythmogenic mechanisms of this mutation. Methods and Results: Ventricular tachycardias under stress conditions were observed in both patients with catecholaminergic polymorphic ventricular tachycardia and knock-in mice. During action potential recording (by patch-clamp in …

Ile de francePhysiologyCPVT030204 cardiovascular system & hematologyArticle03 medical and health sciences0302 clinical medicineaction potential[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular systemPolitical sciencejunctophilinryanodine receptormedia_common.cataloged_instanceHumansEuropean union610 Medicine & health030304 developmental biologymedia_common0303 health sciencescalciumRyanodine Receptor Calcium Release ChannelRyR2musculoskeletal systemSarcoplasmic ReticulumDeath Sudden Cardiaccalcium induced calcium releaseGain of Function Mutationcardiomyocyte calcium handlingcardiovascular systemventricular tachycardiamutationCardiology and Cardiovascular MedicineHumanities
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Malignā hipertermija: diagnostikas, ārstēšanas un profilakses sistēmas ieviešana Latvijā

2011

Elektroniskā versija nesatur pielikumus

Komplikācijas pēc anestēzijasAnesthesia - ComplicationsHipertermijaIVCTMutācijas RYR1 gēnāMutation in RYR1 geneHyperthermiaMedicīna un farmācijaVeselības aprūpeMedicīna
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Institutional systems inducing R&D in Amazon- the role of an investor surplus toward stakeholder capitalization

2020

Abstract Amazon demonstrated a conspicuous increase in R&D and became the world's top R&D firm in 2017 with a skyrocketing increase in market capitalization, making it close to being the world's biggest company. Such a remarkable accomplishment can be attributed to Amazon's institutional systems, which orchestrate techno-financing systems that fuse a unique R&D transformation system and a sophisticated financing system centered on the cash conversion cycle (CCC). These institutional systems support and endorse aggressive investment in R&D that incorporates the characteristics of uncertainty, a long lead time, and successive inflows of very large amounts of funding without interruption. Whil…

Market capitalizationstakeholder capitalizationSociology and Political ScienceFree cash flowFinancial economics020209 energyHuman Factors and Ergonomics02 engineering and technologyEducationGoods and servicestutkimus- ja kehittämistoiminta0502 economics and business0202 electrical engineering electronic engineering information engineeringMarket pricesijoittajatsuuryrityksetBusiness and International ManagementMarket valueAmazongross market valueriskitmarkkina-arvo05 social sciencesCapitalismEconomic surplusCash conversion cycleinvestoinnitpääomasijoittajatComputingMilieux_COMPUTERSANDSOCIETYinvestor surplusBusiness050203 business & managementR&D transformationTechnology in Society
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Redox signaling in acute pancreatitis

2015

Acute pancreatitis is an inflammatory process of the pancreatic gland that eventually may lead to a severe systemic inflammatory response. A key event in pancreatic damage is the intracellular activation of NF-κB and zymogens, involving also calcium, cathepsins, pH disorders, autophagy, and cell death, particularly necrosis. This review focuses on the new role of redox signaling in acute pancreatitis. Oxidative stress and redox status are involved in the onset of acute pancreatitis and also in the development of the systemic inflammatory response, being glutathione depletion, xanthine oxidase activation, and thiol oxidation in proteins critical features of the disease in the pancreas. On th…

NecrosisGSH reduced glutathioneSTAT3 signal transducer and activator of transcription 3ERK extracellular signal-regulated kinasesClinical BiochemistryCCK cholecystokininTRAFs TNF receptor associated factorsReview ArticleIκB kinasePharmacologymedicine.disease_causeBiochemistrySHP small heterodimer partnerSTIM1 stromal interaction molecule 1chemistry.chemical_compoundHATs histone acetyltransferasesMedicineASK1GCL glutamate cysteine ligaseTNF-α tumor necrosis factor alphaIKK IκB kinaseNOS nitric oxide synthaseAcute inflammationHIF hypoxia inducible factorlcsh:QH301-705.5NF-κB nuclear factor kappa BDAMPs damage-associated molecular pattern moleculeslcsh:R5-920biologyGSSG oxidized glutathioneNF-kappa BNLRs nucleotide-binding oligomerization domain (NOD) like receptorsTRADD tumor necrosis factor receptor type 1-associated DEATH domain proteinTRPC3 transient receptor potential channel 3VEGF vascular endothelial growth factorGlutathioneTNFR tumor necrosis factor receptorHMGB1 high-mobility group Box 1 proteinIP3R inositol 145-trisphosphate receptor type 3VCAM-1 Vascular Cell adhesion protein 1Acute DiseaseJNK c-Jun N-terminal kinaseAcute pancreatitisTLRs toll-like receptorsmedicine.symptomlcsh:Medicine (General)Oxidation-ReductionAP-1 activator protein-1Signal TransductionmRNA messenger ribonucleic acidHMGB1ASC apoptosis-associated speck-like protein containing a carboxy-terminal CARDRNS reactive nitrogen speciesPTPs protein tyrosine phosphatasesROS reactive oxygen speciesNADH nicotinamide adenine dinucleotidepHe extracellular pHFAEE fatty acid ethyl estersAP acute pancreatitisHumansXanthine oxidaseCBP CREB-binding proteinRyR endoplasmic reticulum membrane ryanodine receptorsMDA malondialdehydeNO nitric oxideXO xanthine oxidaseASK1 apoptosis signal-regulating kinase-1business.industryOrganic ChemistryAutophagyNADPH nicotinamide adenine dinucleotide phosphateHDACs histone deacetylasesmedicine.diseaseCARS compensatory anti-inflammatory response syndromeXDH xanthine dehydrogenaseIL interleukinIκB inhibitor of kappa BAcute pancreatitisETC Electron transport chainPancreatitisMKPs MAPK phosphatasesSAP severe acute pancreatitischemistrylcsh:Biology (General)DTT dithiothreitolOxidative stressNAC N-acetyl cysteineImmunologybiology.proteinCalciumLysosomesReactive Oxygen SpeciesbusinessMAPK mitogen-activated protein kinaseOxidative stressERCP endoscopic retrograde cholangiopancreatographyRedox Biology
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The role of negative and positive forms of power in supporting CSR alignment and commitment between large firms and SMEs

2018

Do large firms exert power to shape the CSR behavior of their SME partners?” We answer this question by proposing a model built on the stakeholder theory and the shareholder theory, and go on to explain how this impact influences the commitment of the SME towards their large partner. The model highlights the central role that different forms of power exercised by the large firm play in the process. A survey of 291 SMEs confirms the key hypotheses, including the mediating role of reward power. The effects of coercive power are noteworthy and they illustrate the complex and competing forces at play in influencing CSR behavioral change in SMEs. The research makes a novel contribution to practi…

Process (engineering)vallankäyttöCoercionCSR orientationPower (social and political)Shareholderkumppanuusyritysvastuuvaikuttaminen0502 economics and businesssuuryrityksetta512Stakeholder theorynormative commitmentIndustrial organizationMarketing05 social sciencessitoutuminenaffective commitmentCoercive powercontinuance commitmentreward powerKey (cryptography)Corporate social responsibility050211 marketingBusinesscoercive powerpienet ja keskisuuret yritykset050203 business & management
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