Search results for "SAEs"

showing 3 items of 3 documents

Denosumab for bone health in prostate and breast cancer patients receiving endocrine therapy? A systematic review and a meta-analysis of randomized t…

2019

Highlights • Hormonal receptors positive breast tumor and prostate cancer are managed with endocrine therapies. • Endocrine therapies designed for breast and prostate cancer are often associated to serious adverse skeletal related events, such fractures. • Denosumab is a monoclonal anti-body binding RANKL which acts as inhibitor of osteoclasts activity, thus increasing bone mass. • Denosumab was showed to strongly prevent hormonal therapies-related skeletal issues. • Denosumab administration results safe in bone mass increase and reduction of fractures risk.

0301 basic medicineOncologyRCTs randomized clinical trialrandomized clinical trialslcsh:Diseases of the musculoskeletal systemSettore MED/06 - Oncologia MedicaOsteoporosisBMD bone mass densityReview Articleandrogen deprivation therapyADTlaw.inventionAndrogen deprivation therapyProstate cancerhazard ratio0302 clinical medicineRandomized controlled triallawHRMedicineBreastSAEsCancerProstateRANKLCIMD mean differencelcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogensRCTs randomized clinical trialsDenosumabOncology030220 oncology & carcinogenesisSAEs serious adverse eventsDenosumabmean differencemedicine.drugmedicine.medical_specialtylcsh:RC254-28203 medical and health sciencesBreast cancerRANKL receptor activator of nuclear factor-kB ligandBMDInternal medicineAdverse effectADT androgen deprivation therapyRCTsbusiness.industryMDmedicine.diseaseHR hazard ratioHormonereceptor activator of nuclear factor-kB ligandDiscontinuationCI confidence interval030104 developmental biologyFractureconfidence intervalADT androgen deprivation therapy; BMD bone mass density; Breast; CI confidence interval; Cancer; Denosumab; Fracture; HR hazard ratio; Hormone; MD mean difference; Prostate; RANKL receptor activator of nuclear factor-kB ligand; RCTs randomized clinical trials; SAEs serious adverse eventsserious adverse eventsbone mass densitylcsh:RC925-935businessJournal of Bone Oncology
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Chest electrical impedance tomography examination, data analysis, terminology, clinical use and recommendations: consensus statement of the translati…

2017

Electrical impedance tomography (EIT) has undergone 30 years of development. Functional chest examinations with this technology are considered clinically relevant, especially for monitoring regional lung ventilation in mechanically ventilated patients and for regional pulmonary function testing in patients with chronic lung diseases. As EIT becomes an established medical technology, it requires consensus examination, nomenclature, data analysis and interpretation schemes. Such consensus is needed to compare, understand and reproduce study findings from and among different research groups, to enable large clinical trials and, ultimately, routine clinical use. Recommendations of how EIT findi…

Lung DiseasesPathologyPulmonary CirculationLungeTerminologyPaediatric Lung Disaese0302 clinical medicineElectric ImpedanceMedicine1506Medical diagnosisCardiac OutputChildTomographyddc:618Lung Diseases/diagnostic imaging/physiopathology/therapyRespirationHealth technology3. Good healthChild PreschoolArtificialElectrical Impedance Tomography (EIT)Pulmonary and Respiratory MedicineAdultmedicine.medical_specialtyConsensusAssisted VentilationAdolescentTherapy planningImaging/CT MRI etcMedizintechnik03 medical and health sciencesTerminology as TopicState of the Art ReviewHumansMedical physicsIn patientddc:610PreschoolElectrical impedance tomographyStatement (computer science)business.industryInfant NewbornInfant030208 emergency & critical care medicineTOMOGRAFIA COMPUTADORIZADA POR RAIOS XNewbornRespiration ArtificialClinical trial030228 respiratory systemElektrische Impedanz-Tomografie (EIT)ARDSbusinessTomography/methods
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Intimacy in Cinema: Critical Essays on English Language Film

2014

International audience; Though intimacy has been a wide concern in the humanities, it has received little critical attention in film studies. This collection of essays investigates both the potential intimacy of cinema as a medium and the possibility of a cinema of intimacy where it is least expected. As a notion defined by binaries--inside and outside, surface and depth, public and private, self and other--intimacy, because it implies sharing, calls into question the boundaries between these extremes, and the border separating mainstream cinema and independent or auteur cinema. Following on Thomas Elsaesser's theories of the relationship between the intimacy of cinema and the cinema of int…

[SHS.LITT]Humanities and Social Sciences/LiteratureAustralianElsaesser[SHS.ART]Humanities and Social Sciences/Art and art historyintimacy[ SHS.LITT ] Humanities and Social Sciences/Literature[ SHS.ART ] Humanities and Social Sciences/Art and art historymainstream[SHS.LITT] Humanities and Social Sciences/LiteratureEnglish-speaking filmsintimeCinéma anglophoneHollywoodEnglishcinema[SHS.ART] Humanities and Social Sciences/Art and art history[SHS] Humanities and Social SciencesCanadian cinema
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