Search results for "SAF"

Abstracts of papers and posters safe handling of medicines

1993

Gestión de la devolución de tratamientos antineoplásicos y de su reutilización en pacientes oncológicos

2009

Objective: Analyse the profi le of parenteral preparation and treatment (anti-neoplastic and supplementary) that were dispensed and returned to the Pharmacy Department, the reasons why they were not administered, their reuse and the associated direct costs. Method: Longitudinal study over eight months (October 2004-May 2005) in a tertiary hospital with centre for preparing anti-neoplastic agents (including supplementary treatment) in its Pharmacy Department. The variables studied, downloaded from the Oncofarm® application, are as follows: a) patients and diagnostics; b) returned treatments, classifi ed by reason returned, pharmaco-therapeutic scheme, cycle and day; c) returned preparations …

N-Acetylcysteine for Preventing Acetaminophen-Induced Liver Injury: A Comprehensive Review.

2022

Aims: N-Acetylcysteine (NAC) is used as an antidote in acetaminophen (APAP) overdose to prevent and mitigate drug-induced liver injury (DILI). Our objective was to systematically review evidence of the use of NAC as a therapeutic option for APAP overdose and APAP-related DILI in order to define the optimal treatment schedule and timing to start treatment.Methods: Bibliographic databases (PubMed, Web of Science, Embase, and MEDLINE) were searched for retrospective and prospective cohort studies, case series, and clinical trials. The prespecified primary outcomes were DILI-related mortality, hepatotoxicity, and adverse events (AEs).Results: In total, 34 studies of NAC usage in APAP-related DI…

Asymptotic freedom in massive Yang-Mills theory

2007

An effective field theory model of the massive Yang-Mills theory is considered. Assuming that the renormalized coupling constants of 'non-renormalizable' interactions are suppressed by a large scale parameter it is shown that in analogy to the non-abelian gauge invariant theory the dimensionless coupling constant vanishes logarithmically for large values of the renormalization scale parameter.

Background independent quantum field theory and gravitating vacuum fluctuations

2019

The scale dependent effective average action for quantum gravity complies with the fundamental principle of Background Independence. Ultimately the background metric it formally depends on is selected self-consistently by means of a suitable generalization of Einstein's equation. Self-consistent backround spacetimes are scale dependent, and therefore "going on-shell" at the points along a given renormalization group (RG) trajectory requires understanding two types of scale dependencies: the (familiar) direct one carried by the off-shell action functional, and an indirect one related to the self-consistent background geometry. This paper is devoted to a careful delineation and analysis of ce…

Is There a C-Function in 4D Quantum Einstein Gravity?

2016

We describe a functional renormalization group-based method to search for ‘C-like’ functions with properties similar to that in 2D conformal field theory. It exploits the mode counting properties of the effective average action and is particularly suited for theories including quantized gravity. The viability of the approach is demonstrated explicitly in a truncation of 4 dimensional Quantum Einstein Gravity, i.e. asymptotically safe metric gravity.

Geometric operators in the asymptotic safety scenario for quantum gravity

2019

We consider geometric operators, such as the geodesic length and the volume of hypersurfaces, in the context of the Asymptotic Safety scenario for quantum gravity. We discuss the role of these operators from the Asymptotic Safety perspective, and compute their anomalous dimensions within the Einstein-Hilbert truncation. We also discuss certain subtleties arising in the definition of such geometric operators. Our results hint to an effective dimensional reduction of the considered geometric operators.

R2phase diagram of quantum Einstein gravity and its spectral dimension

2012

Within the gravitational asymptotic safety program, the renormalization group (RG) flow of the ${R}^{2}$ truncation in three and four spacetime dimensions is analyzed in detail. In particular, we construct RG trajectories which emanate from the non-Gaussian UV fixed point and possess long classical regimes where the effective average action is well approximated by the classical Einstein-Hilbert action. As an application we study the spectral dimension of the effective quantum Einstein gravity spacetimes resulting from these trajectories, establishing that the picture of a multifractal spacetime is robust under the extension of the truncated theory space. We demonstrate that regimes of const…

Bimetric Renormalization Group Flows in Quantum Einstein Gravity

2011

The formulation of an exact functional renormalization group equation for Quantum Einstein Gravity necessitates that the underlying effective average action depends on two metrics, a dynamical metric giving the vacuum expectation value of the quantum field, and a background metric supplying the coarse graining scale. The central requirement of "background independence" is met by leaving the background metric completely arbitrary. This bimetric structure entails that the effective average action may contain three classes of interactions: those built from the dynamical metric only, terms which are purely background, and those involving a mixture of both metrics. This work initiates the first …

A new functional flow equation for Einstein-Cartan quantum gravity

2015

We construct a special-purpose functional flow equation which facilitates non-perturbative renormalization group (RG) studies on theory spaces involving a large number of independent field components that are prohibitively complicated using standard methods. Its main motivation are quantum gravity theories in which the gravitational degrees of freedom are carried by a complex system of tensor fields, a prime example being Einstein-Cartan theory, possibly coupled to matter. We describe a sequence of approximation steps leading from the functional RG equation of the Effective Average Action to the new flow equation which, as a consequence, is no longer fully exact on the untruncated theory sp…