Search results for "SAF"
showing 10 items of 2183 documents
Pseudo-Media Sites, Polarization, and Pandemic Skepticism in Spain
2021
The Coronavirus pandemic has triggered an authentic infodemic, which is a global epidemic of disinformation that has spread throughout most of the world. Social media platforms and pseudo-media outlets have contributed to the problem by producing and disseminating misleading content that is potentially dangerous to public health. This research focuses on a rather unknown phenomenon, which involves digital sites that mimic the appearance of news media but provide pseudo-information. Five Spanish pseudo-media have been analyzed with the aim of enhancing understanding of the issues and the frames presented. The results show clear links with the far-right ideology as well as the presence of a p…
Governance in the metropolitan area of Valencia (Spain): an unfinished business
2023
Metropolitan government is still an unfinished business in Spain. An example of this is the metropolitan area of Valencia. The aim of this article is to learn about the process that has led to the current situation of a lack of metropolitan government and to propose actions that will help to make it a reality in the not-too-distant future. To this end, it analyses the history and the current regulations, and it is completed with the opinions and contributions of academics and politicians. The result is that, although there is no political will to include the consolidation of a metropolitan government in Valencia in the current political agenda, it is possible to set in motion initiatives of…
Nordic Cooperation in the Nuclear Safety Sector: High, Low, or Differentiated Integration?
2020
Nordic cooperation has been depicted as eroding due to the increased importance of EU-related cooperation and integration. However, scholars propose that longstanding Nordic networks, grounded in professions and located in the state administration, may prove to be more robust toward external changes. This article discusses this proposal by looking at Nordic cooperation between the national radiation protection and nuclear safety authorities in Iceland, Denmark, Norway, Sweden, and Finland. The article maps behavioural perceptions of agency staff based on a dataset of 37 interviews to illustrate if the cooperation between the Nordic authorities is characterized by high integration, low integ…
Changing driver behavior during floods: Testing a novel e-health intervention using implementation imagery
2021
Abstract We tested the efficacy of a novel implementation imagery intervention (N = 460) in promoting safer intentions regarding driving into floodwater post-intervention, and at a four-week follow-up using a pre-registered randomized controlled design. Results showed that the intervention reduced intentions and subjective norms regarding driving into floodwater. The control condition also improved on intentions and subjective norms, but the changes appeared to only be maintained at the follow-up for the intervention group and the between group difference at the follow-up was not significant based on our pre-specified cutoff level for statistical significance of 0.01. Results also indicated…
A dose-ranging study of indacaterol in obstructive airways disease, with a tiotropium comparison.
2008
This dose-ranging study assessed the bronchodilator efficacy and tolerability of indacaterol, a novel once-daily inhaled beta2-agonist, in subjects clinically diagnosed with COPD. Comparative data with tiotropium were collected. In the double-blind, core period of the study, 635 subjects with COPD (prebronchodilator FEV(1)40% of predicted and > or =1.0L; FEV1/FVC <70%) were randomized to receive indacaterol 50, 100, 200 or 400microg or placebo via multi-dose dry powder inhaler, or indacaterol 400microg via single-dose dry powder inhaler, once daily for 7 days. After completing double-blind treatment and washout, a subset of subjects from each treatment group entered an open-label extension …
Efficacy of once-daily tiotropium Respimat in adults with asthma at GINA Steps 2-5.
2020
Tiotropium Respimat is an efficacious add-on to maintenance treatment in patients with symptomatic asthma. Currently, the Global Initiative for Asthma (GINA) strategy recommends tiotropium for patients at Steps 4–5. To assess the clinical benefits of tiotropium Respimat across asthma severities, GINA Steps 2–5, a post hoc analysis of five double-blind trials (12–48-weeks; patients aged 18–75 years) investigated the effect of tiotropium Respimat, 5 μg or 2.5 μg, versus placebo, on peak forced expiratory volume in 1 s (FEV1) within 3 h post-dose (FEV1(0–3h)) response, and Asthma Control Questionnaire-7 (ACQ-7) responder rate. GINA step grouping was based on patients’ background treatment regi…
P149 Once-daily tiotropium Respimat® add-on to at least ICS in adult patients with symptomatic asthma: pooled safety analysis: Abstract P149 Table 1
2015
Background A high proportion of patients with asthma are symptomatic despite at least ICS maintenance therapy. Five trials aimed to evaluate the safety of tiotropium Respimat® compared with placebo Respimat®, each as add-on to at least ICS in adult patients with symptomatic asthma. Methods Five Phase III and one Phase II randomised, double-blind, placebo-controlled, parallel-group trials. PrimoTinA-asthma® (48 weeks): tiotropium Respimat® 5 µg add-on to ICS + LABA (≥800 µg budesonide or equivalent); MezzoTinA-asthma® (24 weeks): tiotropium Respimat® 5 µg or 2.5 µg add-on to ICS (400–800 µg budesonide or equivalent); GraziaTinA-asthma® (12 weeks): tiotropium Respimat® 5 µg or 2.5 µg add-on t…
Validation and utility of ARDS subphenotypes identified by machine-learning models using clinical data: an observational, multicohort, retrospective …
2022
Item does not contain fulltext BACKGROUND: Two acute respiratory distress syndrome (ARDS) subphenotypes (hyperinflammatory and hypoinflammatory) with distinct clinical and biological features and differential treatment responses have been identified using latent class analysis (LCA) in seven individual cohorts. To facilitate bedside identification of subphenotypes, clinical classifier models using readily available clinical variables have been described in four randomised controlled trials. We aimed to assess the performance of these models in observational cohorts of ARDS. METHODS: In this observational, multicohort, retrospective study, we validated two machine-learning clinical classifie…
Safety of tiotropium/olodaterol in chronic obstructive pulmonary disease: pooled analysis of three large, 52-week, randomized clinical trials.
2018
Abstract Background An extensive clinical trial program supports the efficacy and safety of tiotropium/olodaterol in chronic obstructive pulmonary disease (COPD). We examined the safety of tiotropium/olodaterol compared with tiotropium in a large population of patients, focusing on cardiovascular and respiratory events. Methods Patients (n = 9942) who received once-daily tiotropium/olodaterol 5/5 μg or tiotropium 5 μg (via Respimat®) in TONADO 1 & 2 and DYNAGITO were included. The number of patients and exposure-adjusted rate of events are presented for adverse events (AEs), serious AEs (SAEs), AEs leading to discontinuation, and cardiovascular and respiratory events. Findings Fewer patient…
Low-energy epicardial pacing in children: the benefit of autocapture.
1999
Abstract Background . Permanent cardiac pacing in children results commonly in augmented energy consumption because of the high pacing rates and the ample stimulation safety margin applied in children. Cardiovascular anatomy and limited venous access sometimes preclude the otherwise preferred endocardial approach. In this multicenter patient series, we studied the feasibility, safety, and energy saving obtained by a combination of steroid-eluting epicardial leads with autocapture devices capable of ongoing adjustment of the stimulation output to the prevailing threshold. Methods . Autocapture devices (Pacesetter Microny SR+ and Regency SR+; Pacesetter, Solna, Sweden) and steroid-eluting epi…