Search results for "SAF"
showing 10 items of 2183 documents
Efectos vasculares de las nanopartículas de óxido de cerio en la vena safena humana
2022
Las nanopartículas de óxido de cerio (CeO2NPs) podrían tener un futuro prometedor como nanomaterial de uso médico debido a su poder antioxidante y su alta biocompatibilidad, entre otras características. Sin embargo, sus efectos en el sistema cardiovascular están poco estudiados y es por ello que, en la presente tesis nos centramos en el estudio de las CeO2NPs a nivel vascular, utilizando segmentos de vena safena interna humana. Nuestra hipótesis es que las CeO2NPs podrían tener propiedades antioxidantes a nivel vascular, especialmente por actuar como miméticas de la superóxido dismutasa (SOD) y disminuir los niveles del anión superóxido (.O2 ). Esto aumentaría la biodisponibilidad de óxido …
Estudio de la respuesta adrenérgica de la vena safena interna
2014
INTRODUCCION: La cardiopatia isquemica es la primera causa de mortalidad en el mundo en nuestros día y su tratamiento incluye entre otros la revascularización coronaria mediante bypass coronario. El injerto más utilizado en la cirugía de revascularización es la safena interna. El mayor problema de la vena safena es la tasa de oclusión del injerto a medio plazo. HIPOTESIS: Durante la cirugía se produce la liberación de sustancias potencialmente espasmógenicas y cada vez es más frecuente la administración exógena de fármacos inotrópicos para tratar un síndrome de bajo gasto cardíaco perioperatorio. Ambas circuntancias pueden producir vazsoespasmos y provocar una trombosis precoz del injerto. …
Interacciones de la ranolazina con agentes vasoactivos endógenos y exógenos
2022
La ranolazina se utiliza como terapia complementaria en pacientes con cardiopatía isquémica estable que sean intolerantes o no hayan respondido a los antianginosos clásicos. En los últimos años sus indicaciones han aumentado especialmente en el tratamiento de las arritmias y de la insuficiencia cardíaca. Ha demostrado tener un efecto beneficioso en la disfunción diastólica inducida por estrés oxidativo cardíaco, en la angina microvascular y en la diabetes. También ha demostrado ser efectiva en patologías neurológicas como la epilepsia o el dolor crónico, y se le han atribuido propiedades antinflamatorias. Actúa inhibiendo la INaL en los miocitos y ejerce un efecto cardioprotector al evitar …
Economic Robustness Analysis of Adaptive Chart Schemes for Monitoring the Total Nonconformities Number in Inspection Units
2015
In recent years, a variety of enhanced schemes for the c chart have been developed aimed at the effectiveness improving of the related statistical process control (SPC) procedures. However, the performance of such chart schemes can be very sensitive to values assumed for some operating and cost parameters, in particular to the considered process shift magnitude arising from out-of-control conditions. In such a circumstance, the effectiveness of such chart schemes can be subjected to substantial reductions when they are implemented in operative contexts given that, in practice, such value is unknown and it can be very difficult to accurately estimate. For this reason, in the present paper i…
A Multi-Objective Design Approach for the c Chart Considering Taguchi Loss Function
2013
The present paper proposes a multi-objective design approach for the c chart, considering in the optimization process of the chart parameters both the statistical and the economic objectives. In particular, the minimization of the hourly total quality related costs is the considered objective to carry out the economic goal, whereas the statistical objective is reached by the minimization the out-of-control average run length of the chart. A mixed integer non-linear constrained mathematical model is formulated to solve the treated multi-objective optimization problem, whereas the Pareto optimal frontier is described by the e-constraint method. In order to show the employment of the proposed …
Comparing the Economic Effectiveness of Various Adaptive Schemes for the c Chart
2013
In an attempt to improve the effectiveness of statistical process control (SPC) procedures, a variety of adaptive schemes has been developed in the last decades. However, considering control charts for attributes, relatively few works about adaptive schemes have been proposed, and most of them were proposed only recently. The common characteristic of those schemes is that one or more chart parameters are allowed to adaptively vary during the SPC operations according to the sampling information history, typically the current point plotted on the chart. In this way, the adaptive schemes are smarter than the related static ones, but they are also more complicated in terms of implementation. Th…
An Effective Double Sampling Scheme for thecControl Chart
2013
In the present paper is developed a statistical process control inspection procedure based on a new simple-to-implement and effective double sampling scheme for the c control chart, aimed at the minimization of the number of inspected observation units and warranting fixed levels for the type I and II error risks. In particular, the formulations of the false alarm risk α, the power P of the chart, and the expected number of inspected observation units for the developed inspection procedure are given, whereas a macro of Microsoft Excel is adopted to solve the tackled problem. In order to illustrate the application of the developed approach and to investigate on the influence of several opera…
Economic Design Approach for an SPC Inspection Procedure Implementing The Adaptive C Chart
2013
The present paper proposes a design approach for a statistical process control (SPC) procedure implementing a c control chart for non-conformities, with the aim to minimize the hourly total quality-related costs. The latter take into account the costs arising from the non-conforming products while the process is in-control and out-of-control, for false alarms, for assignable cause locations and system repairs, for sampling and inspection activities and for the system downtime. The proposed economic optimization approach is constrained by the expected hourly false alarms frequency, as well as the available labor resource level. A mixed integer non-linear constrained mathematical model is dev…
A hardware skin-segmentation IP for vision based smart ADAS through an FPGA prototyping
2017
International audience; In this paper we presents a platform based design approach for fast HW/SW embedded smart Advanced Driver Assistant System (ADAS) design and prototyping. Then, we share our experience in designing and prototyping a HW/SW vision based smart embedded system as an ADAS that helps to increase the safety of car's drivers. We present a physical prototype of the vision ADAS based on a Zynq FPGA. The system detects the fatigue state of the driver by monitoring the eyes closure and generates a real-time alert. A new HW/SW codesign skin segmentation step to locate the eyes/face is proposed. Our presented new approach migrates the skin segmentation step from processing system (S…
Carbon and safe-haven flows
2022
<abstract> <p>This paper explores the role of European Union Allowances (EUAs) as a safe haven for a range of assets and analyses the effect of safe-haven flows on the European carbon futures market. In particular, we demonstrate that EUAs can be considered a refuge against fluctuations in corporate bonds, gold and volatility-related assets in periods of market turmoil. Furthermore, we have shown that extremely bearish and bullish movements in those assets for which the EUA acts as a safe haven induce excess volatility in carbon markets, higher carbon trading volume and larger than normal EUA bid-ask spreads. These findings support the idea that some traders, by considering carb…