Search results for "SAP"
showing 10 items of 1142 documents
Vers une approche globale de l'évolution des Hominidés
1998
Abstract Two models of diversification of the common ancestor of gorillas, chimpanzees and men can be proposed on the basis of the distribution of chromosomal rearrangements in extant species and reconsideration of the role played by climate. The small genetic divergence between chimpanzees and humans is greatly amplified at the morphological level, thus constituting the ‘human paradox’. This paradox is resolved by the economical and flexible evolutionary mechanism of mutations in regulator genes and the heterochronies they control, which are the true internal clocks of evolution. Changes in cranial morphology are quantified and used to analyse and explain the steps in the transition from g…
The Sas3p and Gcn5p histone acetyltransferases are recruited to similar genes.
2006
A macroarray platform was used to identify binding sites of yeast histone acetyltransferase catalytic subunits and to correlate their positions with acetylation of lysine 14 of histone H3, revealing that Sas3p and Gcn5p are recruited to similar sets of intensely transcribed genes.
Characterization of the NAD-Dependent Human Histone Deacetylases Gene Sirtuin 1 and Its Implications on Aging and the Development of Malignant Diseas…
2006
Abstract A dysregulation of the tightly controlled equilibrium of acetylation and deacetylation plays a causative role in the generation as well as in the suppression of cancer. Histone acetylation modifiers are therefore gaining increasing attention as potential targets in the treatment of cancer. Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, which belongs to the silent information regulator 2 (Sir2) family of sirtuin histone deacetylases (HDACs). The yeast Sir2 protein and its mammalian derivatives play a central role in epigenetic gene silencing, DNA repair and recombination, cell-cycle, microtubule organization, and in the regulation of aging. We…
Identification of sapovirus infection among Japanese infants in a day care center.
2005
A total of 921 fecal specimens collected from 44 infants in a day care center in Tokyo, Japan during June 1999 to July 2000 were tested for the presence of sapovirus by reverse transcription-polymerase chain reaction (RT-PCR). Of 88 fecal specimens from infants with acute gastroenteritis, 2.3% (2) were found to be positive for sapovirus. Twenty-two of 833 (2.6%) fecal specimens collected from asymptomatic infants were also infected with this virus. Another interesting feature was the demonstration of high incidence of sapovirus infection (95.5%, 21 of 22) identified in a single day care center, which was not due to viral shedding after the latest acute gastroenteritis. Sapovirus was subject…
Work-loss years among people diagnosed with diabetes: a reappraisal from a life course perspective
2018
Aims Early exit from the workforce has been proposed to be one of the unfavorable consequences of diabetes. We examined whether early exit from the workforce differed between persons who were and were not diagnosed with diabetes during their work career. Methods The cohort included 12,726 individuals of the Helsinki Birth Cohort Study, born between 1934 and 1944. Using data from nationwide registers, the cohort was followed up from early adulthood until they transitioned into retirement or died. Work- loss years were estimated using the restricted mean work years method. Results During a follow-up of 382,328 person-years for men and 349 894 for women, 36.8% transitioned into old age pension…
La struttura dialettica
2017
Nelle Lezioni di pedagogia fondamentale, curate dall'Autore, questo testo costituisce il secondo capitolo della Quarta unità formativa, dal titolo La pedagogia fondamentale di stile fenomenologico-ermeneutico. Scrive l'Autore in avvio del capitolo: "In questa lezione procederemo seguendo questo metodo della ragione fenomenologica; e il movimento di ripresa potrà valere come approfondimento di quanto visto e argomentato in particolare nella lezione precedente, a proposito della pedagogia fondamentale come logos integrato. In particolare, la nuova focalizzazione sarà operata sopra due tesi che già conosciamo perché ricorrenti e caratterizzanti il nostro modello di ricerca pedagogica: la prima…
Gene silencing induced by oxidative DNA base damage: association with local decrease of histone H4 acetylation in the promoter region
2010
Oxidized DNA bases, particularly 7,8-dihydro-8-oxoguanine (8-oxoG), are endogenously generated in cells, being a cause of carcinogenic mutations and possibly interfering with gene expression. We found that expression of an oxidatively damaged plasmid DNA is impaired after delivery into human host cells not only due to decreased retention in the transfected cells, but also due to selective silencing of the damaged reporter gene. To test whether the gene silencing was associated with a specific change of the chromatin structure, we determined the levels of histone modifications related to transcriptional activation (acetylated histones H3 and H4) or repression (methylated K9 and K27 of the hi…
Triterpenoid saponins from the roots of two Gypsophila species.
2013
Two triterpenoid saponins with two known ones have been isolated from the roots of Gypsophila arrostii var. nebulosa, and two new ones from the roots of Gypsophila bicolor. Their structures were established by extensive NMR and mass spectroscopic techniques as 3-O-β-d-galactopyranosyl-(1→2)-[β-d-xylopyranosyl-(1→3)]-β-d-glucuronopyranosylquillaic acid 28-O-β-d-xylopyranosyl-(1→4)-[β-d-glucopyranosyl-(1→3)]-α-l-rhamnopyranosyl-(1→2)-[β-d-glucopyranosyl-(1→4)]-β-d-fucopyranosyl ester (1), 3-O-β-d-galactopyranosyl-(1→2)-[β-d-xylopyranosyl-(1→3)]-β-d-glucuronopyranosylgypsogenin 28-O-β-d-xylopyranosyl-(1→4)-[β-d-glucopyranosyl-(1→3)]-α-l-rhamnopyranosyl-(1→2)-[β-d-glucopyranosyl-(1→4)]-β-d-fuco…
Successive alkalinity producing system for the treatment of acid sulphate soil runoff: preliminary results of a field trial
2005
A successive alkalinity producing system (SAPS) has been investigated as a potential passive treatment option for acid, metal containing runoff from acid sulphate soil. A pilot-scale system was installed at an agricultural land site in Rintala embankment area in mid-western Finland. The experimental layout consists of three parallel treatment units: two different SAPS cells and one limestone-filled cell for comparison of performance. The SAPS cells are composed of a bottom layer of limestone and a top layer of compost supplemented with sand. One of the SAPS cells contains sulphate-rich, waste gypsum mixed with the compost layer in order to enhance the metal reduction by sulphate reducing-ba…
Protection of Patient Data in Digital Oral and General Health Care: A Scoping Review with Respect to the Current Regulations
2023
The use of digital health technologies, including telemedicine and teledentistry, has become a necessity in healthcare due to the SARS-CoV-19 pandemic. These technologies allow for the reduction of the workload of healthcare providers and the improvement of patient outcomes in cases of remote monitoring, diagnosis, and communication. While there are no doubtful benefits, there are some counterparts, such as concerns about clinical risks, data security, and privacy protection. This paper aims to review the regulations regarding the use of digital health apps and software in healthcare. This scoping review followed the PRISMA-ScR guidelines and the five-step framework of Arksey and O’Malley. …