Search results for "SARS-COV-2"

Machine learning for mortality analysis in patients with COVID-19

2020

This paper analyzes a sample of patients hospitalized with COVID-19 in the region of Madrid (Spain). Survival analysis, logistic regression, and machine learning techniques (both supervised and unsupervised) are applied to carry out the analysis where the endpoint variable is the reason for hospital discharge (home or deceased). The different methods applied show the importance of variables such as age, O2 saturation at Emergency Rooms (ER), and whether the patient comes from a nursing home. In addition, biclustering is used to globally analyze the patient-drug dataset, extracting segments of patients. We highlight the validity of the classifiers developed to predict the mortality, reaching…

COVID-19 Pandemic: New Prevention and Protection Measures

2022

As of the end of February 2021, more than 420,000,000 confirmed cases of COVID-19 have been reported worldwide, with 5,856,224 deaths. Transmission of the different genetically engineered variants of SARS-CoV-2, which have been isolated since the beginning of the pandemic, occurs from one infected person to another by the same means: the airborne route, indirect contact, and occasionally the fecal–oral route. Infection is asymptomatic or may present with flulike symptoms such as fever, cough, and mild to moderate and severe respiratory distress, requiring hospitalization and assisted ventilation support. To control the spread of COVID-19, the World Health Organization (WHO) and Centers for …

Understanding the challenges of rapid digital transformation : the case of COVID-19 pandemic in higher education

2021

Rapid digital transformation is taking place due to the COVID-19 pandemic, forcing organisations and higher educational institutions to change their working and learning culture. This study explores the challenges of rapid digital transformation arising during the pandemic in the higher education context. This research used the Q-methodology to understand the nine challenges that higher education encountered, perceived differently as four main patterns: (1) Digital-nomad enterprise; (2) Corporate-collectivism; (3) Well-being-oriented; and (4) Pluralistic. This study broadens the current understanding of digital transformation, especially in higher education. The nine challenges and four pat…

Acute Mesenteric Ischemia in COVID-19 Patients.

2022

Acute mesenteric ischemia is a rare but extremely severe complication of SARS-CoV-2 infection. The present review aims to document the clinical, laboratory, and imaging findings, management, and outcomes of acute intestinal ischemia in COVID-19 patients. A comprehensive search was performed on PubMed and Web of Science with the terms “COVID-19” and “bowel ischemia” OR “intestinal ischemia” OR “mesenteric ischemia” OR “mesenteric thrombosis”. After duplication removal, a total of 36 articles were included, reporting data on a total of 89 patients, 63 being hospitalized at the moment of onset. Elevated D-dimers, leukocytosis, and C reactive protein (CRP) were present in most reported cases, a…

Editorial: The Effect of the COVID-19 Pandemic on Cancer Patients and Healthcare

2022

An immunologist's guide to immunosenescence and its treatment

2022

Abstract Introduction: Aging causes several changes in the immune system, although immune aging is strongly influenced by individual immunological history, as well as genetic and environmental factors leading to inter-individual variability. Areas covered: We focused on the biological and clinical meaning of immunosenescence. SARS-CoV-2 and Yellow Fever vaccine have demonstrated the clinical relevance of immunosenescence, while inconsistent results, obtained from longitudinal studies aimed at looking for immune risk phenotypes, have revealed that immunosenescence is highly context-dependent. Large projects allowed the delineation of the drivers of immune system variance, including genetic a…

Short-Term Outcomes of Patients With COVID-19 Undergoing Invasive Mechanical Ventilation: A Retrospective Observational Study From Wuhan, China.

2020

Background: COVID-19 has spread rapidly worldwide. Many patients require mechanical ventilation. The goal of this study was to investigate the clinical course and outcomes of patients with COVID-19 undergoing mechanical ventilation and identify factors associated with death. Methods: Eighty-three consecutive critically ill patients with confirmed COVID-19 undergoing invasive mechanical ventilation were included in this retrospective, single-center, observational study from January 31 to March 15, 2020. Demographic, clinical, laboratory, radiological, and mechanical ventilation data were collected and analyzed. The primary outcome was 28-day mortality after endotracheal intubation. The secon…

Jaunas tendences probiotiskajā terapijā

2021

Mūsdienās palielinās pētījumu aktualitāte, kas saistīti ar mikrobioma ietekmi uz cilvēka organisma funkcijām. Analizējot probiotikas saturošu līdzekļu sortimentu un pieprasījumu aptiekās, un aptaujājot farmācijas un kosmetoloģijas speciālistus, pētījuma rezultātā tika novērtētas probiotisko terapijas tendenču izmaiņas. Joprojām galvenais lietošanas mērķis ir gremošanas sistēmas traucējumu mazināšana, tomēr arvien biežāk probiotikas tiek ieteiktas kā līdzeklis imunitātes un ādas veselības uzlabošanai. Aprites dati liecina, ka pēdējā gada laikā aptiekās pieprasījums pēc probiotikām ir samazinājies. Secināts, ka visbiežāk kosmetoloģijas speciālisti iesaka probiotikas ādas sausuma un acne vulga…

Learning to survive amidst nested crises: can the coronavirus pandemic help us change educational practices to prepare for the impending eco-crisis?

2021

The ongoing ecological crisis and the more recent Coronavirus crisis challenge the grand narrative of Enlightenment that human beings are ‘masters of nature’. For millennia, human social learning has allowed Homo sapiens to outpace most of our competitor creatures and live a comfortable life, but this competitive success has resulted in cataclysmic failure for the ecosystem. However, people’s unique ability to learn gives us hope that we can overcome the nested crises, or learn to live with them. What is required is not more knowledge, but instead, collective learning to change practices, institutionalized in educational processes. Drawing on the theory of practice architectures, this paper…

Immune Response Failure in Paucisymptomatic Long-Standing SARS-CoV-2 Spreaders

2021

The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has rapidly spread throughout the world. This disease has a spectrum of different clinical pictures with different outcomes. Herein, we report all the data from three paucisymptomatic patients during a hospital stay that might represent a paradigmatic example of the method by which SARS-CoV-2 is shed. We demonstrated the lack of an adequate qualitative and quantitative immune response by multiparametric flow cytometry analysis. Our data can provide a new perspective about the method by which SARS-CoV-2 is shed and the clinical weight of viral persistence. In all three cases, the …