Search results for "SAS"
showing 10 items of 2933 documents
An essential switch in subunit composition of a chromatin remodeling complex during neural development.
2007
Summary Mammalian neural stem cells (NSCs) have the capacity to both self-renew and to generate all the neuronal and glial cell-types of the adult nervous system. Global chromatin changes accompany the transition from proliferating NSCs to committed neuronal lineages, but the mechanisms involved have been unclear. Using a proteomics approach, we show that a switch in subunit composition of neural, ATP-dependent SWI/SNF-like chromatin remodeling complexes accompanies this developmental transition. Proliferating neural stem and progenitor cells express complexes in which BAF45a, a Kruppel/PHD domain protein and the actin-related protein BAF53a are quantitatively associated with the SWI2/SNF2-…
Efectos de la exposición crónica al etanol sobre el tráfico intracelular y citoesqueleto como factores implicados en la migración neuronal
2013
El consumo de etanol durante la gestación puede inducir una serie de alteraciones graves en el desarrollo del feto, la manifestación más extrema da lugar al Síndrome Alcohólico Fetal (SAF). La exposición prenatal al alcohol es la causa conocida y, además evitable, más importante de retraso mental en el mundo occidental. Además de déficits cognitivos, los niños con SAF presentan múltiples anomalías estructurales en el sistema nervioso central, como reducción de la masa cerebral, y a nivel celular, daños en la migración neuronal, en el proceso de formación de espinas dendríticas y establecimiento de sinapsis. En la actualidad, los mecanismos moleculares implicados en la teratogénesis inducida…
La nécropole Néolithique moyen d’Obernai ‘Neuen Brunnen’ (Bas-Rhin) : rites funéraires de la première moitié du 5e millénaire dans le sud de la plain…
2020
The Obernai ’Neuen Brunnen’ necropolis in Lower Alsace yielded 29 tombs attributed to the Middle Neolithic. It was probably founded during the Early Grossgartach, at the end of the 48th century BC, and abandoned during the Roessen, perhaps during the Early Roessen, and in any case before the middle of the 46th century BC. The most original feature of this mortuary assemblage is that most of the tombs belong to the Planig-Friedberg period (the last stylistic phase of the Grossgartach) and the Roessen. The mortuary practices of these periods are still poorly known in the region. The necropolis is composed of three spatial groups, the most ancient of which contains all the Grossgartach tombs a…
Endringskapasitet – en nøkkel for å lykkes med gevinstrealisering i spesialisthelsetjenesten? : En studie av hvordan mellomledere opplever at endring…
2018
Masteroppgave i helse- og sosialinformatikk HSI500 - Universitetet i Agder 2018 Background: If an organisation is to reap the potential benefits of new technology, it must modify its work processes. However, the specialist health service appears to be experiencing significant challenges because it is constantly under pressure to change and improve its efficiency. This can weaken its capacity for change and, at worst, lead to long-term reductions in productivity and efficiency. Purpose: The purpose of this study is to examine how middle managers in the specialist health service feel they can influence developments in change capacity. The aim is to contribute to an awareness of the importance…
Macchina del fango e demonizzazione dell’avversario. Sulla nozione di diabole nella retorica greca.
2014
The topic of this paper is the rhetorical notion of diabole: a charge that attempts to cast the opponent in a negative light in order to create a negative prejudice in the audience. It is a rhetorical strategy similar to what is currently called a “character assassination” (in Italian “macchina del fango”), a strategy aimed at discrediting and vilifying the adversary using any means. Therefore, it is a phenomenon that involves the important question concerning the role of ethos in the persuasive process. The paper focuses on a particularly insidious aspect of diabole: its use as a form of counterattack. This means that diabole can be dangerous not only when it is used to discredit or vilify…
PUBLIC TRUST IN CHARITIES : EVIDENCES FROM FINLAND AND SWEDEN
2019
Master's thesis Innovative governance and public management ME523 - University of Agder 2019 Public sector across the globe is currently experiencing a decline in public trustand this issue has been widelydiscussed across the globe. While working as a fundraiser in summer 2018, the author discovered that charities are struggling to recruit and keep their regular donors. Donations from general people areone of the mainsources of charity funding. Individuals who donate to charities do not receive a direct benefit in exchange for their support to charities. Moreover, they don’t have all the necessary information, on which they can decide to donate. Trust is what facilitates the transactions be…
When Violence Can Appear With Different Male Partners: Identification of Resilient and Non-resilient Women in the European Union
2018
Introduction: Little scholarly attention has been paid to the analysis of the history of intimate partner violence (IPV) against women with different male partners and how it could be related to levels of IPV with the current male partner. From this point of view, been a victim of IPV could increase the vulnerability of women and, therefore, exert a negative influence on the selection of partners over time, thus increasing the odds of potentially mating with abusive male partners. Alternatively, for some women victims of IPV in previous relationships, there may be additional resources that reduce their vulnerability to victimization by new partners. Methodology: The present study analyzes l…
Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells
2009
Epigenetic mechanisms that maintain neurogenesis throughout adult life remain poorly understood(1). Trithorax group (trxG) and Polycomb group (PcG) gene products are part of an evolutionarily conserved chromatin remodelling system that activate or silence gene expression, respectively(2). Although PcG member Bmi1 has been shown to be required for postnatal neural stem cell self-renewal(3,4), the role of trxG genes remains unknown. Here we show that the trxG member Mll1 (mixed-lineage leukaemia 1) is required for neurogenesis in the mouse postnatal brain. Mll1-deficient subventricular zone neural stem cells survive, proliferate and efficiently differentiate into glial lineages; however, neur…
An Investigation of the Seasonal Pattern of Mannitol Content in Deciduous and Evergreen Species of the Oleaceae Growing in Northern Sicily
2002
In several species of the Oleaceae, mannitol, already present at considerable levels, accumulates in response to stress. This family comprises both deciduous and evergreen species, and we investigated the role of mannitol in deciduous malacophyll and evergreen sclerophyll species growing under the same conditions in the field. The relationship between mannitol content and changes in rainfall or temperature was also studied. The mannitol content of leaves of Fraxinus ornus L., F. angustifolia Vahl., Olea europaea L. and Phillyrea media L. was determined by gas chromatography. Leaf samples were collected once a month for 1 year. In the two ash species, the seasonal pattern of mannitol content…
Los cibermedios valencianos : Cartografía, características y contenidos
2008
167 p.