Search results for "SCA"
showing 10 items of 23299 documents
Absolute quantification of noncoding RNA by microscale thermophoresis
2019
Abstract Accurate quantification of the copy numbers of noncoding RNA has recently emerged as an urgent problem, with impact on fields such as RNA modification research, tissue differentiation, and others. Herein, we present a hybridization‐based approach that uses microscale thermophoresis (MST) as a very fast and highly precise readout to quantify, for example, single tRNA species with a turnaround time of about one hour. We developed MST to quantify the effect of tRNA toxins and of heat stress and RNA modification on single tRNA species. A comparative analysis also revealed significant differences to RNA‐Seq‐based quantification approaches, strongly suggesting a bias due to tRNA modifica…
Accuracy, Coherence, and Discrepancy in Self and Other Reports: Moving Toward an Interactive Perspective of Organizational Dissent.
2013
The purpose of this study was twofold and involved examining the viability of using the Organizational Dissent Scale as an other-report instrument, and developing additional perceptual data related to dissent expression. A sample of 291 people completed survey questionnaire measures of organizational dissent. Equal-sized groups ( n = 97) completed either a self-report, a workplace colleague other-report, or an organizational outsider other-report. Results indicated the Organizational Dissent Scale performed reliably as an other-report, but it showed some tendency for social desirability. In addition, findings suggested that certain indicators of proximity to the dissenter reduced discrepan…
A novel heuristic memetic clustering algorithm
2013
In this paper we introduce a novel clustering algorithm based on the Memetic Algorithm meta-heuristic wherein clusters are iteratively evolved using a novel single operator employing a combination of heuristics. Several heuristics are described and employed for the three types of selections used in the operator. The algorithm was exhaustively tested on three benchmark problems and compared to a classical clustering algorithm (k-Medoids) using the same performance metrics. The results show that our clustering algorithm consistently provides better clustering solutions with less computational effort.
Interface Detection Using a Quenched-Noise Version of the Edwards-Wilkinson Equation
2015
We report here a multipurpose dynamic-interface-based segmentation tool, suitable for segmenting planar, cylindrical, and spherical surfaces in 3D. The method is fast enough to be used conveniently even for large images. Its implementation is straightforward and can be easily realized in many environments. Its memory consumption is low, and the set of parameters is small and easy to understand. The method is based on the Edwards-Wilkinson equation, which is traditionally used to model the equilibrium fluctuations of a propagating interface under the influence of temporally and spatially varying noise. We report here an adaptation of this equation into multidimensional image segmentation, an…
A Hybrid Multigroup Coclustering Recommendation Framework Based on Information Fusion
2015
Collaborative Filtering (CF) is one of the most successful algorithms in recommender systems. However, it suffers from data sparsity and scalability problems. Although many clustering techniques have been incorporated to alleviate these two problems, most of them fail to achieve further significant improvement in recommendation accuracy. First of all, most of them assume each user or item belongs to a single cluster. Since usually users can hold multiple interests and items may belong to multiple categories, it is more reasonable to assume that users and items can join multiple clusters (groups), where each cluster is a subset of like-minded users and items they prefer. Furthermore, most of…
Volkswagen Emission Crisis : Managing Stakeholder Relations on the Web
2016
Organizations establish their own profiles at social media sites to publish pertinent information to customers and other stakeholders. During a long and severe crisis, multiple issues may emerge in media interaction. Positive responses and prompt interaction from the official account of e.g. a car manufacturer creates clarity and reduces anxiety among stakeholders. This research targets the Volkswagen 2015 emission scandal that became public on Sept. 18, 2015. We report its main phases over time based on public web information. To better understand the online interaction and reactions of the company, we scrutinized what information was published on VW’s official web sites, Facebook, and Twi…
Super-fit and population size reduction in compact Differential Evolution
2011
Although Differential Evolution is an efficient and versatile optimizer, it has a wide margin of improvement. During the latest years much effort of computer scientists studying Differential Evolution has been oriented towards the improvement of the algorithmic paradigm by adding and modifying components. In particular, two modifications lead to important improvements to the original algorithmic performance. The first is the super-fit mechanism, that is the injection at the beginning of the optimization process of a solution previously improved by another algorithm. The second is the progressive reduction of the population size during the evolution of the population. Recently, the algorithm…
Synchronous R-NSGA-II: An Extended Preference-Based Evolutionary Algorithm for Multi-Objective Optimization
2015
Classical evolutionary multi-objective optimization algorithms aim at finding an approx- imation of the entire set of Pareto optimal solutions. By considering the preferences of a decision maker within evolutionary multi-objective optimization algorithms, it is possible to focus the search only on those parts of the Pareto front that satisfy his/her preferences. In this paper, an extended preference-based evolutionary algorithm has been proposed for solving multi-objective optimiza- tion problems. Here, concepts from an interactive synchronous NIMBUS method are borrowed and combined with the R-NSGA-II algorithm. The proposed synchronous R-NSGA-II algorithm uses preference information provid…
Support vector machine integrated with game-theoretic approach and genetic algorithm for the detection and classification of malware
2013
Abstract. —In the modern world, a rapid growth of mali- cious software production has become one of the most signifi- cant threats to the network security. Unfortunately, wides pread signature-based anti-malware strategies can not help to de tect malware unseen previously nor deal with code obfuscation te ch- niques employed by malware designers. In our study, the prob lem of malware detection and classification is solved by applyin g a data-mining-based approach that relies on supervised mach ine- learning. Executable files are presented in the form of byte a nd opcode sequences and n-gram models are employed to extract essential features from these sequences. Feature vectors o btained are…
Can back-projection fully resolve polarity indeterminacy of independent component analysis in study of event-related potential?
2011
a b s t r a c t In the study of event-related potentials (ERPs) using independent component analysis (ICA), it is a traditional way to project the extracted ERP component back to electrodes for correcting its scaling (magnitude and polarity) indeterminacy. However, ICA tends to be locally optimized in practice, and then, the back-projection of a component estimated by the ICA can possibly not fully correct its polarity at every electrode. We demonstrate this phenomenon from the view of the theoretical analysis and numerical simulations and suggest checking and modifying the abnormal polarity of the projected component in the electrode field before further analysis. Moreover, when several co…