Search results for "SCAR"
showing 10 items of 914 documents
Acetylcholine receptors (muscarinic) in GtoPdb v.2021.3
2021
Muscarinic acetylcholine receptors (mAChRs) (nomenclature as agreed by the NC-IUPHAR Subcommittee on Muscarinic Acetylcholine Receptors [50]) are activated by the endogenous agonist acetylcholine. All five (M1-M5) mAChRs are ubiquitously expressed in the human body and are therefore attractive targets for many disorders. Functionally, M1, M3, and M5 mAChRs preferentially couple to Gq/11 proteins, whilst M2 and M4 mAChRs predominantly couple to Gi/o proteins. Both agonists and antagonists of mAChRs are clinically approved drugs, including pilocarpine for the treatment of elevated intra-ocular pressure and glaucoma, and atropine for the treatment of bradycardia and poisoning by muscarinic age…
Efficacy of tiotropium and olodaterol fixed-dose combination in patients with COPD on β-blockers
2015
Introduction: The efficacy and safety of a new once-daily (QD) fixed-dose combination (FDC) with tiotropium (T), a long-acting muscarinic antagonist, and olodaterol (O), a long-acting β 2 -agonist, was established for the treatment of COPD in the TONADO studies (NCT01431274; NCT01431287). This analysis evaluates the efficacy of the FDC in a subpopulation of patients receiving β-blockers (BBs) in these studies. Methods: Two replicate, randomised, double-blind, parallel-group, 52-week, Phase III trials assessed the efficacy and safety of T+O FDC (2.5/5 μg; 5/5 μg; Respimat ® inhaler) QD compared to the monocomponents. Key primary end point data for the combined analysis of the replicate trial…
Risk factors associated with adverse fetal outcomes in pregnancies affected by Coronavirus disease 2019 (COVID-19): a secondary analysis of the WAPM …
2020
Abstract Objectives To evaluate the strength of association between maternal and pregnancy characteristics and the risk of adverse perinatal outcomes in pregnancies with laboratory confirmed COVID-19. Methods Secondary analysis of a multinational, cohort study on all consecutive pregnant women with laboratory-confirmed COVID-19 from February 1, 2020 to April 30, 2020 from 73 centers from 22 different countries. A confirmed case of COVID-19 was defined as a positive result on real-time reverse-transcriptase-polymerase-chain-reaction (RT-PCR) assay of nasal and pharyngeal swab specimens. The primary outcome was a composite adverse fetal outcome, defined as the presence of either abortion (pre…
Tracce di vita collegiale a Ca' Dolfin: alcuni estratti significativi dalle testimonianze e dai materiali dei Cadolfiniani
2014
Il capitolo traccia la storia del Collegio di Merito istituito presso Ca' Dolfin all'Università Ca' Foscari di Venezia.
New insight into the genetics of age-related macular degeneration in connection with lipid metabolism
2010
Evaluation of: Zerbib J, Seddon JM, Richard F et al. rs5888 variant of SCARB1 gene is a possible susceptibility factor for age-related macular degeneration. PLoS ONE 4(10), e7341 (2009).Age-related macular degeneration (AMD) is the leading cause of visual loss in elderly populations of Western countries. According to demographic forecasts, and owing to the improvement in life expectancy, the number of people suffering from this pathology is expected to dramatically increase in the near future, thereby becoming a significant socioeconomic burden. There has been great progress in defining risk factors for AMD over the last few decades. Beyond advanced age, environmental and genetic factors ha…
Submarine Mass Movements Along a Sediment Starved Margin: The Menorca Channel (Balearic Islands - Western Mediterranean)
2014
6th International Symposium on Submarine Mass Movements and Their Consequences (ISSMMTC), 23-25 September 2013, Kiel, Germany.-- 10 pages, 5 figures
Ability of short-time Fourier transform method to detect transient changes in vagal effects on hearts: a pharmacological blocking study.
2006
Conventional spectral analyses of heart rate variability (HRV) have been limited to stationary signals and have not allowed the obtainment of information during transient autonomic cardiac responses. In the present study, we evaluated the ability of the short-time Fourier transform (STFT) method to detect transient changes in vagal effects on the heart. We derived high-frequency power (HFP, 0.20–0.40 Hz) as a function of time during active orthostatic task (AOT) from the sitting to standing posture before and after selective vagal (atropine sulfate 0.04 mg/kg) and sympathetic (metoprolol 0.20 mg/kg) blockades. The HFP minimum point during the first 30 s after standing up was calculated and…
Carlo Scarpa. Una [curiosa] lama di luce, un gonfalone d’oro, le mani e un viso di donna : riflessioni sul processo progettuale per l’allestimento di…
2020
Seconda edizione aggiornata e ampliata febbraio 2020. L’organizzazione spaziale di tutta la Galleria Regionale di Palazzo Abatellis è un luogo di mediazioni complesse fra l’impegno progettuale scarpiano, il senso di misura e di armonia complessiva e le istanze del curatore Giorgio Vigni. Il volume, nella sua struttura, cerca di far comprendere il collegamento fra il luogo e il processo progettuale del “fare scarpiano”, scartando la cronologia dell’intervento stesso con riflessioni che riguardano la strategia dei percorsi, e forse svelano un possibile messaggio in codice. Si tratta di una ricognizione mirata, la cui narrazione è ricomposta anche grazie ad alcuni indizi (rinvenuti durante lo …
Carlo Scarpa e la sala del dubbio di palazzo Abatellis
2016
Questo articolo descrive, da un disegno di studio e da foto d'archivio, la sala del dubbio in divenire al processo di progettazione. E' uno sguardo alla realizzazione di Scarpa con la consapevolezza che le forme e gli allestimenti di palazzo Abatellis, stabiscono alla scala di dettaglio; "raccontare" di possibili somiglianze tra il dispositivo e le relazioni spaziali che si instaura con gli occhi del visitatore. This paper describes, from a study design and the photo archive, the challenge of the lost set-up in the making that the design process. It's a look at the making Scarpa with the knowledge that forms and exhibitions for Abatellis palace, established the scale of detail; "recount" of…
Loss of input from the mossy cells blocks maturation of newly generated granule cells.
2007
The objective of this work is to check whether the input from the mossy cells to the inner molecular layer is necessary for the integration and maturation of the newly generated granule cells of the dentate gyrus (DG) in mice, and if after status epilepticus the sprouting of the mossy fibers can substitute for this projection. Newly generated cells were labeled by administration of 5-bromo-deoxyuridine either before or after pilocarpine administration. The neuronal loss in the hippocampus after administration of pilocarpine combined with scopolamine and diazepam seemed restricted to the hilar mossy cells. The maturation of the granule cells was studied using immunohistochemistry for calreti…