Search results for "SCAR"

Allosteric modulation of nicotinic acetylcholine receptors as a treatment strategy for Alzheimer's disease

2000

The basic symptoms of Alzheimer's dementia, i.e., a loss in cognitive function, are due to impaired nicotinic cholinergic neurotransmission. To compensate for this impairment by drug treatment, blockers of the acetylcholine-degrading enzyme acetylcholinesterase are applied, even though this approach obviously is prone to many side-effects, including those of muscarinic nature. We have recently described a novel class of nicotinic acetylcholine receptor ligands which, similar to the action of benzodiazepines on GABA(A) receptors, allosterically potentiate submaximal nicotinic responses. The sensitizing effect is a consequence of facilitated channel opening in the presence of allosterically p…

2021

Introduction: Digital health technologies such as self-monitoring devices and apps are becoming increasingly important as tools to promote healthy habits and support individuals in their self-care. There is still a scarcity of research that builds on motivational theory to better understand the functioning of digital health technologies. The self-determination theory (SDT) is a macro theory of motivation that delineates three basic psychological needs that are linked to different types of motivation and lead to well-being when satisfied and illbeing when frustrated.Objective: To explore how the use of a digital tool for self-monitoring and communication with healthcare satisfies or frustrat…

Atropine-resistant effects of the muscarinic agonists McN-A-343 and AHR 602 on cardiac performance and the release of noradrenaline from sympathetic …

1974

Abstract 1 The effects of 4-(m-chlorophenylcarbamoyloxy)-2-butynyltrimethylammonium chloride (McN-A-343) and N-benzyl-3-pyrrolidyl acetate methobromide (AHR 602) on cardiac performance and noradrenaline release from terminal sympathetic fibres were measured in isolated perfused hearts of rabbits. 2 In the presence of sufficient atropine to block muscarinic receptors, high concentrations of McN-A-343 and AHR 602 caused no cardiac stimulation and there was no increase in the resting output of noradrenaline into the perfusates. 3 McN-A-343 and AHR 602 increased both the mechanical responses and the transmitter overflow evoked by electrical stimulation of the sympathetic nerves (SNS) but inhibi…

Correspondencia de Gregorio Mayáns y Siscar con Ignacio Jordán Amo del Río y Miguel de Manuel Rodríguez (1771-1780)

1966

Correspondencia entre juristas españoles del siglo XVIII.

L’assedio di Palermo del 1071-1072 nei «Gesta Roberti Wiscardi» di Guglielmo il Pugliese

2021

L’intervento si propone di mettere in evidenza alcune caratteristiche (compositive, ideologico-politiche, retorico-stilistiche) dei «Gesta Roberti Wiscardi» di Guglielmo il Pugliese, l’unico poema epico-storico del sec. XI-XII che tratti della conquista normanna dell’Italia meridionale. I «Gesta Roberti Wiscardi» contano 2833 esametri suddivisi in cinque libri, con un prologo e un epilogo, e si inseriscono in quel vasto ambito di poesia epico-storica (e fondamentalmente celebrativa ed encomiastica) che, dal periodo tardoantico conduce alla ricca produzione di storie e cronache versificate che costituisce una delle più ricorrenti tendenze della letteratura mediolatina durante il sec. XII (e …

End-user Need based Creation of a Medical Device: An Experience of Co-design to Struggle Pathological Scars

2020

International audience; Scar is a common visible mark of human tissue healing. Sometimes pathological phenomena lead to abnormal hypertrophic or keloid scars, with evolutions varying depending on different conditions: origin of the tissue barrier disruption, concerned body area, or ethnic origin. Based on these statements, care procedures have been developed to avoid aesthetical or functional impairments: drugs injection, surgery, cryotherapy or mechanical compression. The story will relate the matching of a multi-disciplinary team that focused on covering an unmet need for ear lobe keloid treatment, providing patients an optimal and holistic care. The benefits researched lied in improving …

The Gender of the Cartesian Mind, Body, and Mind-Body Union

2019

The chapter examines what we can know about gender from the perspective of the three primary notions introduced by Descartes in his correspondence with Princess Elisabeth of Bohemia. The first section discusses how the primitive notion of the mind strengthens the idea that “the mind has no sex”, an idea that was further developed by the Cartesian and early feminist François Poulain de la Barre. The next section focuses on the notion of the body and analyses what Descartes has to say about gender in his anatomical writings. The little known posthumously published notes Primae cogitationes circa generationem animalium receive particular attention. Here Descartes assumes a difference between t…

The Economic Impact of the South-North Water Transfer Project in China: A Computable General Equilibrium Analysis

2006

Water resources are unevenly spread in China. Especially the basins of the Yellow, Hui and Hai rivers in the North are rather dry. To increase the supply of water in these basins, the South-to-North Water Transfer project (SNWT) was launched. Using a computable general equilibrium model this study estimates the impact of the project on the economy of China and the rest of the world. We contrast three alternative groups of scenarios. All are directly concerned with the South-to-North water transfer project to increase water supply. In the first group of scenarios additional supply implies productivity gains. We call it the “non-market” solution. The second group of scenarios is called “marke…

The economic impact of water taxes: a computable general equilibrium analysis with an international data set

2008

Water is scarce in many countries. One instrument for improving the allocation of a scarce resource is (efficient) pricing or taxation. However, water is implicitly traded on international markets, particularly through food and textiles, so that the impacts of water taxes cannot be studied in isolation, but require an analysis of international trade implications. We include water as a production factor in a multi-region, multi-sector computable general equilibrium model (GTAP), to assess a series of water tax policies. We find that water taxes reduce water use and lead to shifts in production, consumption and international trade patterns. Countries that do not levy water taxes are nonethele…

The Economic Impact of Restricted Water Supply: a Computable General Equilibrium Analysis

2007

Water problems are typically studied at the level of the river catchment. About 70% of all water is used for agriculture, and agricultural products are traded internationally. A full understanding of water use is impossible without understanding the international market for food and related products, such as textiles. The water embedded in commodities is called virtual water. Based on a general equilibrium model, we offer a method for investigating the role of water resources and water scarcity in the context of international trade. We run five alternative scenarios, analyzing the effects of water scarcity due to reduced availability of groundwater. This can be a consequence of physical con…