Search results for "SCAR"

showing 10 items of 914 documents

Symptom variability and control in COPD: Advantages of dual bronchodilation therapy

2017

Abstract Background Chronic obstructive pulmonary disease (COPD) is a heterogeneous disorder characterized by usually progressive development of airflow obstruction that is not fully reversible. While most patients will experience symptoms throughout the day or in the morning upon awakening, many patients do not experience their symptoms as constant but report variability in symptoms during the course of the day or over time. Symptom variability adversely affects patients' health status and increases the risk of COPD exacerbations. Methods We examined data from the literature on symptom variability and control in patients with COPD, with focus on the use of inhaled bronchodilator therapy wi…

Aclidinium; Chronic obstructive pulmonary disease; Dual bronchodilator therapy; Formoterol; Lung function; Symptom variability; Pulmonary and Respiratory MedicineAclidiniumHealth StatusVital CapacityHealth StatuPulmonary Disease Chronic Obstructive0302 clinical medicineForced Expiratory VolumeFormoterol FumarateBronchodilatorBronchodilationFormoterol030212 general & internal medicineAclidinium; Chronic obstructive pulmonary disease; Dual bronchodilator therapy; Formoterol; Lung function; Symptom variability; Administration Inhalation; Adrenergic beta-2 Receptor Agonists; Bronchodilator Agents; Disease Progression; Dose-Response Relationship Drug; Drug Therapy Combination; Forced Expiratory Volume; Formoterol Fumarate; Health Status; Humans; Muscarinic Antagonists; Pulmonary Disease Chronic Obstructive; Quality of Life; Treatment Outcome; Tropanes; Vital CapacityLung functionCOPDbiologyChronic obstructive pulmonary diseaseTropaneLamaBronchodilator AgentsMuscarinic AntagonistTreatment OutcomeInhalationAdministrationCombinationDisease ProgressionDrug Therapy CombinationDrugHumanmedicine.drugAdrenergic beta-2 Receptor AgonistPulmonary and Respiratory MedicineChronic Obstructivemedicine.medical_specialtymedicine.drug_classSymptom variabilitySocio-culturaleMuscarinic AntagonistsSettore MED/10 - Malattie Dell'Apparato RespiratorioDose-Response RelationshipPulmonary Disease03 medical and health sciencesDrug TherapyAdministration InhalationmedicineHumansIntensive care medicineAdrenergic beta-2 Receptor AgonistsBronchodilator AgentDose-Response Relationship Drugbusiness.industryMuscarinic antagonistDual bronchodilator therapymedicine.diseasebiology.organism_classificationLung functionrespiratory tract diseasesAclidinium; Chronic obstructive pulmonary disease; Dual bronchodilator therapy; Formoterol; Lung function; Symptom variability; Administration Inhalation; Adrenergic beta-2 Receptor Agonists; Bronchodilator Agents; Disease Progression; Dose-Response Relationship Drug; Drug Therapy Combination; Forced Expiratory Volume; Formoterol Fumarate; Health Status; Humans; Muscarinic Antagonists; Pulmonary Disease Chronic Obstructive; Quality of Life; Treatment Outcome; Tropanes; Vital Capacity; Pulmonary and Respiratory MedicineDual bronchodilation030228 respiratory systemQuality of LifeFormoterolbusinessTropanesRespiratory Medicine
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Los años de la hegemonía socialista. 1983-1995

2007

"Los años de la hegemonía socialista. 1983-1995" es un capítulo escrito por Benito Sanz en la obra colectiva editada por el diario Levante: "La Gran Historia de la Comunitat Valenciana. La democracia reconquistada. De la Transición a la normalización democrática (1975-2008)", tomo 10, dirigida por Francesc A. Martínez y Antonio Laguna. Valencia 2007. "Los años de la hegemonía socialista. 1983-1995" recoge las tres legislaturas en las que el PSPV-PSOE gobernó de forma hegemónica casi todas las instituciones publicas de España, la Comunidad Valenciana, así como las tres diputaciones provinciales, los tres ayuntamientos de las capitales de las provincias y la gran mayoría de los municipios. Jo…

Adolfo SuárezAltos Hornos del Mediterráneo (AHM) de Sagunto:CIENCIA POLÍTICA [UNESCO]transiciónAlfonso GuerraUNESCO::CIENCIA POLÍTICACCOO del País ValenciaPartido Socialista Obrero Español:SOCIOLOGÍA [UNESCO]Eduardo ZaplanaComunitat ValencianapantanadaRafael BlascoUNESCO::SOCIOLOGÍARicard Pérez CasadoAlianza PopularCiprià CíscarFelipe GonzálezAntonio García Miralles
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La Adoración de los Magos. Imagen de la Epifanía en el arte de la Antigüedad

1992

Análisis e interpretación iconográfica de la Adoración de los magos en el arte de los primeros siglos. Como tipo iconográfico, la Adoración de los Magos es considerada en el momento y circunstancias en que fue creado y difundido, contrastándolo con sus homólogas paganas como tema de encuadre. Siguiendo los procedimientos de la iconografía-iconología tradicional, se explican intertextualmente representaciones pictóricas de las catacumbas, esculturas de los sarcófagos y otras manifestaciones. Su sentido es puesto en relación con textos de las Escrituras, la liturgia, sermones y tratados teológicos, dirigido todo hacia una comprensión hermenéutica. Iconographic analysis and interpretation of t…

Adoración de los MagosParusíaDíptico de ErevanUNESCO::HISTORIA::Historia por especialidades::Historia del arteEpifaníaSarcófago Dogmáticoiconografía cristianaSan Apolinar NuovoSarcófago de Saint-MaximinSarcófago de CherchellSarcófago de Layosiconografía:HISTORIA::Historia por especialidades::Historia del arte [UNESCO]Sarcófago de Castiliscarampollas de Monza
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Early management of COPD: Where are we now and where do we go from here? a delphi consensus project

2019

Fabiano Di Marco,1 Piero Balbo,2 Francesco de Blasio,3 Vittorio Cardaci,4 Nunzio Crimi,5 Giuseppe Girbino,6 Girolamo Pelaia,7 Pietro Pirina,8 Pietro Roversi,9 Pierachille Santus,10,11 Nicola Scichilone,12 Alessandro Vatrella,13 Patrizio Pasqualetti,14 Mauro Carone15 1Department of Health Sciences, University of Milan, Respiratory Unit, Papa Giovanni XXIII Hospital, Bergamo, Italy; 2SC Malattie dell’Apparato Respiratorio, AOU Maggiore della Carità, Novara, Italy; 3Respiratory Medicine and Pulmonary Rehabilitation Section, Clinic Center S.p.A. Private Hospital, Department of Medicine and Health Sciences “V Tiberio”, University of Molise, Campobasso, It…

Adrenergic beta-2 Receptor AgonistPulmonary and Respiratory Medicinedrug combinationspractice guidelines as topicConsensuPredictive Value of Testbronchodilator therapy; dyspnea; italy; respiratory symptoms; adrenal cortex hormones; adrenergic beta-2 receptor agonists; adult; bronchodilator agents; consensus; delphi technique; drug combinations; early diagnosis; early medical intervention; evidence-based medicine; female; humans; italy; male; middle aged; muscarinic antagonists; practice guidelines as topic; predictive value of tests; pulmonary disease; chronic obstructive; surveys and questionnaires; treatment outcomeadrenal cortex hormonesSettore MED/10 - Malattie Dell'Apparato RespiratorioInternational Journal of Chronic Obstructive Pulmonary DiseasedyspnoeaAdrenal Cortex HormonePulmonary Disease Chronic ObstructivemaleDrug CombinationEarly Diagnosiitalymiddle agedSurveys and Questionnairehumansmuscarinic antagonistsBronchodilator AgentOriginal Researchearly medical interventionpulmonary diseaselcsh:RC705-779chronic obstructiveHealth Policyadultbronchodilator agentsEnvironmental and Occupational Healthrespiratory symptomsbronchodilator therapylcsh:Diseases of the respiratory systemdyspneaBronchodilator therapy; Dyspnea; Italy; Respiratory symptoms; Pulmonary and Respiratory Medicine; Health Policy; Public Health Environmental and Occupational Healthpredictive value of testsMuscarinic AntagonistfemaleconsensusRespiratory symptomsurveys and questionnairestreatment outcomePublic Healthdelphi techniqueadrenergic beta-2 receptor agonistsevidence-based medicineHumanearly diagnosis
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Nonlinear coupling is absent in acute myocardial patients but not healthy subjects.

2008

We investigated whether autonomic nervous system imbalance imposed by pharmacological blockades and associated with acute myocardial infarction (AMI) is manifested as modifications of the nonlinear interactions in heart rate variability signal using a statistically based bispectrum method. The statistically based bispectrum method is an ideal approach for identifying nonlinear couplings in a system and overcomes the previous limitation of determining in an ad hoc way the presence of such interactions. Using the improved bispectrum method, we found significant nonlinear interactions in healthy young subjects, which were abolished by the administration of atropine but were still present afte…

AdultAtropineMaleSympathetic Nervous SystemPhysiologyAdrenergic beta-AntagonistsModels NeurologicalMyocardial InfarctionMuscarinic AntagonistsElectrocardiographyHeart RateParasympathetic Nervous SystemPhysiology (medical)medicineAutonomic nervous systemHumansMyocardial infarctionNonlinear couplingHeart rate variabilityAgedBispectrumModels Statisticalbusiness.industryHealthy subjectsAge FactorsModels CardiovascularReproducibility of ResultsHeartMiddle Agedmedicine.diseasePropranololAutonomic nervous systemNonlinear DynamicsAnesthesiaCase-Control StudiesSettore ING-INF/06 - Bioingegneria Elettronica E InformaticaFemalebusinessCardiology and Cardiovascular MedicineAlgorithmsAmerican journal of physiology. Heart and circulatory physiology
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False positive rate of an arrayCGH platform for single-cell preimplantation genetic screening and subsequent clinical application on day-3

2013

In this work, false positive rate of an arrayCGH platform for its use in day-3 single-blastomere analysis was calculated. For this purpose, 38 embryos diagnosed as abnormal on day-3 by FISH were re-biopsied on day-4. Single-cell day-4 arrayCGH diagnosis was then performed. A successful amplification was obtained in 97.4 % (37/38) of the day-4 cells analysed by arrayCGH. Day-3 FISH and day-4 arrayCGH diagnosis were concordant in 35/37 cases. The two discordant embryos were spread and all the cells from each embryo were re-analysed by FISH on day 5. The same error rate (2.7 %) for day-3 FISH and day-4 arrayCGH was obtained when comparing day-5 FISH re-analysis. After this pre-clinical phase, …

AdultBlastomeresmedicine.medical_specialtyTime FactorsPregnancy RateBiopsyConcordanceClinical pregnancyBiologySensitivity and SpecificityMiscarriagePregnancyarrayCGHDay-5 FISH re-analysisGeneticsmedicineChromosomes HumanHumansFalse Positive ReactionsEmbryo ImplantationGenetic TestingProspective StudiesIn Situ Hybridization FluorescenceGenetics (clinical)CryopreservationGynecologyComparative Genomic HybridizationReproducibility of ResultsObstetrics and GynecologyGeneral MedicineAneuploidyEmbryo Transfermedicine.diseaseBlastocystReproductive MedicineBlastomere biopsyBlastomere biopsyFish <Actinopterygii>Day-3 PGSFemaleFalse positive rateDevelopmental Biology
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Recurrent cerebral ischaemia in a pregnant woman with patent foramen ovale II° and thrombophilia.

2014

SummaryThis case report concerns a pregnant multipara (age: 27 years) in the 16th gestational week. She developed a sudden onset of paraesthesia in her left lower arm although injecting dalteparin 5000 IU once daily subcutaneously (s. c.) due to a heterozygous factor V Leiden mutation and a prior miscarriage in the first pregnancy and preeclampsia in her third pregnancy. After the miscarriage she delivered two healthy children under prophylactic anticoagulation with low molecular weight heparin (LMWH). Now via magnetic resonance imaging (MRI) she was diagnosed as having multiple cerebral ischaemic lesions. Further workup revealed the presence of a patent foramen ovale (PFO) II° but no venou…

AdultDalteparinmedicine.medical_specialtymedicine.drug_classInjections SubcutaneousPregnancy Complications CardiovascularLow molecular weight heparinForamen Ovale PatentThrombophiliaPreeclampsiaMiscarriageBrain IschemiaPregnancyRecurrencemedicineHumansThrombophiliaPregnancybusiness.industryPregnancy Complications HematologicAnticoagulantsHematologymedicine.diseaseSurgeryVenous thrombosisTreatment OutcomeAnesthesiaPatent foramen ovaleGestationFemalebusinessHamostaseologie
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Increasing the probability of selecting chromosomally normal embryos by time-lapse morphokinetics analysis

2013

Objective To study the differences in the cleavage time between chromosomally normal and abnormal embryos and to elaborate an algorithm to increase the probability of noninvasively selecting chromosomally normal embryos. Design Retrospective cohort study. Setting University-affiliated infertility center. Patient(s) Preimplantation genetic screening patients (n = 125; n=77 with ET), including cases of repeated implantation failure or recurrent miscarriage. A total of 504 embryos were analyzed. Intervention(s) Embryo culture within a time-lapse system. Main Outcome Measure(s) Kinetic variables included the time to 2 (t2), 3 (t3), 4 (t4), and 5 (t5) cells as well as the length of the second (c…

AdultInfertilityBiologyLogistic regressionTime-Lapse ImagingCohort StudiesAndrologyPregnancyRecurrent miscarriagemedicineHumansEmbryo ImplantationPreimplantation DiagnosisProbabilityRetrospective StudiesChromosome AberrationsGeneticsObstetrics and GynecologyEmbryoEmbryo cultureOdds ratioEmbryo Transfermedicine.diseaseConfidence intervalEmbryo transferReproductive MedicineFemaleFertility and Sterility
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Urea cycle dysregulation in non-alcoholic fatty liver disease.

2018

Background & Aims: In non-alcoholic steatohepatitis (NASH), the function of urea cycle enzymes (UCEs) may be affected, resulting in hyperammonemia and the risk of disease progression. We aimed to determine whether the expression and function of UCEs are altered in an animal model of NASH and in patients with non-alcoholic fatty liver disease (NAFLD), and whether this process is reversible. Methods: Rats were first fed a high-fat, high-cholesterol diet for 10 months to induce NASH, before being switched onto a normal chow diet to recover. In humans, we obtained liver biopsies from 20 patients with steatosis and 15 with NASH. Primary rat hepatocytes were isolated and cultured with free fatty …

AdultMale0301 basic medicinemedicine.medical_specialtyCarbamoyl-Phosphate Synthase (Ammonia)Ornithine transcarbamylase03 medical and health scienceschemistry.chemical_compound0302 clinical medicineAmmoniaGlutamate-Ammonia LigaseNon-alcoholic Fatty Liver DiseaseInternal medicineGene expressionmedicineAnimalsHumansUreaRats WistarPromoter Regions GeneticCells CulturedOrnithine CarbamoyltransferaseAgedHepatologyChemistryFatty liverHyperammonemiaDNA MethylationMiddle Agedmedicine.diseaseRats030104 developmental biologyEndocrinologyLiverUrea cycleHepatocytesUreaFemale030211 gastroenterology & hepatologySteatohepatitisSteatosis
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Soil-transmitted helminth infections at very high altitude in Bolivia

2001

A cross-sectional study of soil-transmitted helminthiases in the Northern Bolivian Altiplano was carried out over the 6-year period 1992-97. Prevalences, intensities and associations were analysed from coprological results obtained in 31 surveys (28 in schools and 3 in individuals of all age-groups) performed in 24 Aymara communities located between the city of La Paz and Lake Titicaca, at an altitude of 3800-4200 m. Ascaris lumbricoides and Trichuris trichiura were detected, with local prevalences in the range 1.2-28.0% and 0.0-24.0%, respectively. Significant differences in prevalence rates of trichuriasis were detected, with highest prevalences in male schoolchildren and in subjects aged…

AdultMaleBoliviaVeterinary medicineAdolescentCross-sectional studyTrichuriasisHelminthiasisPrevalenceBiologySoilAge DistributionAltitudeAscariasisPrevalencemedicineHumansSex DistributionChildEggs per gramAgedAltitudePublic Health Environmental and Occupational HealthInfantGeneral MedicineMiddle Agedmedicine.diseasebiology.organism_classificationCross-Sectional StudiesInfectious DiseasesChild PreschoolTrichuris trichiuraFemaleParasitologyAscaris lumbricoidesTransactions of the Royal Society of Tropical Medicine and Hygiene
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