Search results for "SCAR"

Descartes: Ethics and Politics

2017

Este artículo analiza la moral y la filosofía política cartesiana. Defiende que la posición de Descartes en estos ámbitos es congruente con sus concepciones metafísicas y físicas. Una posición que busca un difícil equilibrio entre individualismo y altruismo, vida retirada y compromiso social. This paper analyses Cartesian ethics and politics. It defends that Descartes's position in these areas coincides with his metaphysical and physical conceptions, searching a difficult equilibrium between individualism and altruism, quiet life and social commitment.

An unexpected ring carboxylation in the electrocarboxylation of aromatic ketones

2006

The electrocarboxylation of various aromatic ketones, carried out in N-methyl-2-pyrrolidone (NMP) in a diaphragmless cell equipped with a carbon cathode and an aluminium sacrificial anode, yielded, among the products, the target hydroxy acids, the corresponding alcohols and pinacols and, quite surprisingly, detectable amounts of substituted benzoic acids and cycloexene carboxylic acids. These compounds arise from a never reported before electrocarboxylation on the aromatic ring, respectively, for substitution of an aromatic hydrogen and from an addition reaction. For example, the electrocarboxylation of acetophenone gave rise to the substituted benzoic acids in ortho, para and meta position…

Synthese und pharmakologische Wirkung von carbocyclischen Muskarinanalogen

1974

Als carbocyclische Muskarinanaloga wurden das (3-Hydroxycyclopentylmethyl)trimethyl-ammonium-jodid und dessen Acetat dargestellt und am isolierten Ileum des Meerschweinchens untersucht. Synthesis and Pharmacological Activity of Carbocyclic Analogs of Muscarine As carbocyclic analogs of muscarine (3-hydroxycyclopentylmethyl)trimethylammonium iodide and (3-acetoxycyclopentylmethyl)trimethylammonium iodide were synthesized and tested on the isolated guinea pig ileum.

El desasosiego como «Lebensgefühl» de la vida fáctica. La impronta de Agustín en el joven Heidegger

2018

Este artículo analiza la importancia del desasosiego (cor inquietum) como sentimiento vital (Lebensgefühl) en la interpretación fenomenológica del libro X de las Confesiones que Martin Heidegger realizó durante las lecciones del semestre de verano de 1921 en la Universidad de Friburgo. A tal efecto se prestará una especial atención a la matriz intencional del curare (Bekümmerung) y a la tensión implícita de su doble movilidad (defluxus y continentia) como antecendentes del cuidado (Sorge). Asimismo se tendrá en cuenta el papel de la tentación como experiencia histórica radical de la puesta en cuestión de sí mismo (quaestio mihi factus sum). Todo ello tiene lugar, además, sobre el trasfondo …

Hahmojen välisiä suhteita : interfiguraalisuus Donna Tarttin romaanissa The Secret History

2017

Tutkielma käsittelee interfiguraalisuutta – intertekstuaalisuuden alalajia, joka viittaa eri teksteissä esiintyvien henkilöhahmojen välisiin suhteisiin – Donna Tarttin romaanissa The Secret History. Tarttin romaanin päähenkilöitä tarkastellaan suhteessa neljän muun romaanin henkilöhahmoihin (F. Scott Fitzgeraldin The Great Gatsby, William Goldingin Lord of the Flies, Evelyn Waugh’n Brideshead Revisited sekä Oscar Wilden The Picture of Dorian Gray). Tutkielmassa eri teksteissä esiintyvien henkilöhahmojen välisiä interfiguraalisia kytköksiä peilataan suhteessa The Secret Historyn kertojan luotettavuuteen ja romaanin keskeisiin teemoihin. Tutkimusongelmana on, millaista potentiaalia interfigur…

Elisabeth on Free Will, Preordination, and Philosophical Doubt

2021

Elisabeth is widely known as a critic of René Descartes' account of mind--body interaction and scholarly interpretations of her view on the will most often pose the question about the freedom of the will in relation to bodily impulses such as the passions. This chapter takes a different perspective and focuses on the problem of the compatibility of free will and providence, as it is discussed in a sequence of six letters that Elisabeth and Descartes wrote between September 1645 and January 1646. The chapter focuses on this specific metaphysical problem in order to ask what Elisabeth's remarks on the topic can tell about her general philosophical method as well as about her particular philos…

The importance of being consistent : comparison of translation strategies in two Finnish versions of Oscar Wilde's most famous comedy

2001

Pathogenic Role of Complement in Antiphospholipid Syndrome and Therapeutic Implications

2018

Antiphospholipid syndrome (APS) is an acquired autoimmune disease characterized by thromboembolic events, pregnancy morbidity, and the presence of antiphospholipid (aPL) antibodies. There is sound evidence that aPL act as pathogenic autoantibodies being responsible for vascular clots and miscarriages. However, the exact mechanisms involved in the clinical manifestations of the syndrome are still a matter of investigation. In particular, while vascular thrombosis is apparently not associated with inflammation, the pathogenesis of miscarriages can be explained only in part by the aPL-mediated hypercoagulable state and additional non-thrombotic effects, including placental inflammation, have b…

Tiotropium in asthma: Back to the future of anticholinergic treatment

2017

Abstract Asthma is among the most common chronic diseases worldwide; however, despite progresses in the understanding of the patho-physiological mechanisms and advances in the development of new therapeutic options and strategies, the disease remains uncontrolled in a not trivial proportion of subjects. Thus, the need of new molecules to treat the underlying biological and functional abnormalities and to control symptoms is strongly advocated by clinicians. In this scenario, the most recent GINA guidelines have included the use of tiotropium bromide in the most severe and uncontrolled forms of the disease, in addition to treatment with inhaled corticosteroid plus long acting beta adrenergic…

Agenda y Cuaderno de Nueva York: La paradoja entre la identidad íntima y la máscara múltiple

2012

José Hierro es recordado en la historia de la literatura española por la poetización en sus obras de posguerra de un claro yo autoral, que cobra sentido casi siempre en cuanto englobado en el nosotros de una generación concreta y real: los textos hierrianos dan la impresión de estar hablando siempre en clave personal, si bien las confesiones se quedan muchas veces en el ámbito de lo público, raras veces sumergiéndose en la introspección de lo íntimo, esfera que, como es sabido, el poeta solía respetar con abundante prudencia en todos los aspectos de su vida. Todo ello se construye con las oportunas marcas de realismo o realemas, que conducen al lector en la pista de una lectura más o menos …