Search results for "SCHEDULE"
showing 10 items of 567 documents
Impact of decision horizon on post-prognostics maintenance and missions scheduling: a railways case study
2021
International audience; In this paper, we propose a study of the decision horizon duration for rolling stock mission assignment and maintenance planning in a prognostics and health management (PHM) context. The aim is to determine the best decision horizon duration that allows the con- struction of a suitable schedule that assigns railway vehicles to missions and integrates required maintenance operations accord- ing to the current and future health of the vehicles. A genetic algorithm is used to minimize the overall cost of the joint schedule as a function of the decision horizon. The results are compared to three proposed heuristics to study the influence of the resolution method on the d…
Competition for long-haul connecting traffic among airports in Europe and the Middle East
2017
Abstract This paper analyzes the competitive position of major hub airports in Europe and the Middle East for long-haul connecting traffic. We apply a connection builder to construct competitive flight connections. A stand out feature of the proposed connection builder is the calibration of the model parameters using booking data, composed of actual passenger demand between a given origin and destination (O&D) market. The methodology is applied to measure competition between hubs using flight schedule data to calculate connectivity measures like the number of city-pairs connected via a hub airport. Our results show that the Middle Eastern hubs have improved their competitive position, while…
Schedule-Based Integrated Intercity Bus Line Planning via Branch-and-Cut
2018
This work addresses integrated line planning for intercity bus lines, which differs in several respects from line planning in public transit. Passengers in intercity transportation decide on specific timetabled services to get to their destination. This is a contrast to an urban setting with higher frequencies, where it is generally sufficient to choose a line. Furthermore, intercity bus transportation in deregulated markets is usually characterized by fierce competition within and across modes. Customers are highly sensitive to price, time of day, duration, convenient access to stations, and service quality. Hence, bus line operators need to decide thoroughly on every single timetabled se…
Branch-and-Price-and-Cut for the Periodic Vehicle Routing Problem with Flexible Schedule Structures
2019
This paper addresses the periodic vehicle routing problem with time windows (PVRPTW). Therein, customers require one or several visits during a planning horizon of several periods. The possible visiting patterns (schedules) per customer are limited. In the classical PVRPTW, it is common to assume that each customer requires a specific visit frequency and offers all corresponding schedules with regular intervals between the visits. In this paper, we permit all kinds of schedule structures and the choice of the service frequency. We present an exact branch-and-price-and-cut algorithm for the classical PVRPTW and its variant with flexible schedules. The pricing problems are elementary shortes…
Cimo: An efficient 2-phases calculator of multimodal itineraries for real trans-territories based on a dynamic programming
2015
In this work we propose an exact solution for calculating multimodal itinerary. This solution is named Cimo (Calculateur d'Itineraires Multimodaux Ordonnes). Cimo is an exact optimal itineraries' calculator wherein itineraries are sorted, multimodal, and trans-territorial. The solution is based on a dynamic programming algorithm "cut", "price" and "share". This solution is multi-objectives and multi-constraints. Several versions of this algorithm are proposed following a methodological approach that enables evaluation of efficiency and complexity's gain : through theoretical calculus and benchmarks. In the first version of realistic problem, we propose a solution with itineraries calculated…
Automatic crack detection results using a novel device for survey and analysis of road pavement condition
2019
To accurately schedule maintenance operations, it is crucial to monitor the pavement state and, thus, evaluate the structural and functional indices during its entire service life. In particular, surface conditions (cracks, potholes, patches, rutting, etc.) must be properly checked – especially in terms of detection, identification, and classification of distresses – for avoiding reaching dangerous values for users (overpassing safety thresholds). However, monitoring and survey activities can be so costly (not only in economic terms, but further considering the execution time) to discourage their execution, with evident drawbacks for a proper maintenance management and the related intervent…
Efficacy of an internet-based psychological intervention for problem gambling and gambling disorder: study protocol for a randomized controlled trial
2021
Gambling Disorder is a prevalent non-substance use disorder, which contrasts with the low number of people requesting treatment. Information and Communication Technologies (ICT) could help to enhance the dissemination of evidence-based treatments and considerably reduce the costs. The current study seeks to assess the efficacy of an online psychological intervention for people suffering from gambling problems in Spain. The proposed study will be a two-arm, parallel-group, randomized controlled trial. A total of 134 participants (problem and pathological gamblers) will be randomly allocated to a waiting list control group (N = 67) or an intervention group (N = 67). The intervention program i…
Oral metronomic cyclophosphamide with and without methotrexate as palliative treatment for patients with metastatic breast carcinoma
2012
Oral metronomic chemotherapy is a therapeutic option which is particularly attractive due to its ease of administration and low toxic burden. Its mechanism of action probably involves antiangiogenetic effect rather than a classical antiproliferative effect like standard maximally tolerated dose-based regimens.A retrospective analysis of 61 patients with advanced breast carcinoma was carried out with the aim of reporting activity in terms of response rate, control of tumor-related symptoms, outcome, and toxicity. All patients had hormonal therapy-resistant metastatic disease and had previously received two lines of chemotherapy. The first cohort of 22 patients received oral cyclophosphamide …
Once-Daily Liraglutide Versus Lixisenatide as Add-on to Metformin in Type 2 Diabetes: A 26-Week Randomized Controlled Clinical Trial
2016
OBJECTIVE To compare the efficacy and safety of liraglutide versus lixisenatide as add-on to metformin in patients with type 2 diabetes not achieving adequate glycemic control on metformin alone. RESEARCH DESIGN AND METHODS In this 26-week, randomized, parallel-group, open-label trial, 404 patients were randomized 1:1 to liraglutide 1.8 mg or lixisenatide 20 µg as add-on to metformin. Liraglutide was administered once daily at any time of the day. Lixisenatide was administered once daily within 1 h prior to the morning or evening meal. RESULTS At week 26, liraglutide reduced HbA1c (primary end point) more than lixisenatide (estimated treatment difference −0.62% [95% CI −0.8; −0.4]; P &…
A phase IIA study of the topoisomerase I inhibitor, exatecan mesylate (DX-8951f), administered at two different dose schedules in patients with plati…
2004
OBJECTIVES: There is an urgent need for new agents with activity in platinum- and taxane-resistant epithelial ovarian cancer. Exatecan mesylate is a novel topoisomerase I inhibitor with potent activity against ovarian cancer in vitro. A multicentre phase IIA study was conducted in patients with platinum- and taxane-resistant epithelial ovarian cancer. PATIENTS AND METHODS: Fifty-seven patients with bidimensionally measurable ovarian cancer, previously exposed to platinum and taxanes, whose disease had relapsed within 6 months of platinum-containing chemotherapy were randomised to one of two intravenous schedules of exatecan mesylate; 0.3 mg/m(2) daily for 5 days every 3 weeks (Arm A) or 2.1…