Search results for "SCOPE"

Contextualising Baxtin’s Linguistic Ideas

2012

Summary This article discusses the origins and formation of the notion of ‘metalinguistics’ in Mixail Mixajlovič Baxtin’s (1895–1975) writings. It is argued that the discussion of metalinguistics and the division of labour within the study of language in the United States in the 1940s and 1950s may have exerted a more profound influence on the formation of Baxtin’s linguistic views than was previously thought. The article investigates the nature and extent of this interaction and shows that there are interesting parallels between Baxtin’s conception of metalinguistics and the metalinguistics writings of George L. Trager (1906–1992). This suggests that, apart from any purely terminological i…

Dual Labeling of Lipopolysaccharides for SPECT-CT Imaging and Fluorescence Microscopy.

2013

International audience; : Lipopolysaccharides (LPS) or endotoxins are amphipathic, pro-inflammatory components of the outer membrane of Gram-negative bacteria. In the host, LPS can trigger a systemic inflammatory response syndrome. To bring insight into in vivo tissue distribution and cellular uptake of LPS, dual labeling was performed with a bimodal molecular probe designed for fluorescence and nuclear imaging. LPS were labeled with DOTA-Bodipy-NCS, and pro-inflammatory properties were controlled after each labeling step. LPS were then radiolabeled with (111)In and subsequently injected intravenously into wild-type, C57B16 mice, and their in vivo behavior was followed by single photon emis…

Transmission electron microscopical studies on some haemolymph proteins from the marine polychaete Nereis virens.

2001

Abstract The hexagonal bilayer haemoglobin molecule from Nereis virens has been investigated in a comparative study using several different negative stain electron microscopical specimen preparations (i.e. by conventional adsorption to continuous carbon support films, by the negative staining-carbon film technique and by negative staining across the holes of holey carbon support films with air-drying and rapid freezing/cryo-negative staining). The benefits and limitations of these different approaches are indicated, with the overall conclusion that negative staining with ammonium molybdate across holes creates the best possibilities for molecular imaging, and also has the potential for the …

1987

Preparation de vesicules contenant une matrice polymere reticule hydrophile (couches bimoleculaires phospholipides revetues de microparticules polymeres)

A comparison between the chemical behaviour of lead-gold and lead-bismuth eutectics towards 316L stainless steel

2013

Radiochimica acta, 101 (10)

NOVCOJUSĪ LEKSIKA J. LANGIJA VĀRDNĪCĀ (1685): NAUDAS VIENĪBU NOSAUKUMI

2021

The Latvian language dictionary of J. Langius (1685) does not contain a large number of terms denoting monetary units – altogether there are 11 of them (ārtaugs, dālderis, diķis, eiduks, grosis, kauss, mārka, skatiks, sķiliņģis, vērdiņģis, zelta gabals), as well as some other money-related lexemes (e.g., sīknauda, vara nauda etc.) which are not designations of monetary units and therefore are not analyzed in this article. These lexemes are included in most 17–19th century dictionaries, and sometimes are borrowed from one dictionary into another. For instance, J. Langius has taken over the words included in the dictionary of G. Mancelius, but later J. Lange, in his turn, refers to J. Langius…

Ultrastructure of alcoholic hyalin and fate of the affected hepatocytes

1977

In liver biopsy specimens, foci of satellitosis, i.e., foci of alcoholic hyalin containing hepatocytes surrounded by accumulated leukocytes, were studied by means of electron-microscopic investigation. Within satellitosis hepatocytes, the same morphologic variants of alcoholic hyalin were observed as formerly described in nonsatellitosis liver cells: (1) clusters of randomly oriented smooth filaments of homogenous electron density, (2) bundles of filaments aligned in parallel arrays and exhibiting irregular densities and indistinct boundaries, and (3) masses of a strongly osmiophilic amorphous material, presumably lipidic in nature. The individual hyalin body was composed of one, two, or al…

Structure and electronic properties of ultrathin Co films on W(110)

2004

Abstract The structure and electronic properties of ultrathin Co films on W(1 1 0) grown by molecular beam epitaxy in UHV were investigated by low energy electron diffraction (LEED) and scanning tunneling microscopy and spectroscopy (STM and STS). For coverages above 0.7 ML the pseudomorphic (ps) monolayer is transformed gradually into close-packed (cp-) monolayer areas, showing up as separated islands that increase in size with coverage until the cp-monolayer is complete. Two different structures of the cp-monolayer were observed by atomically resolved STM, both leading to a 8 × 1 superstructure in the LEED pattern. Higher coverages continue to grow in the Stransky–Krastanov growth mode fo…

Complement pore genesis observed in erythrocyte membranes by fluorescence microscopic single-channel recording

1991

The formation and opening of single complement pores could be directly observed in erythrocyte ghosts by confocal laser-scanning microscopy employing the recently introduced method of fluorescence microscopic single-channel recording. Resealed sheep erythrocyte ghosts were incubated with human complement. By limiting the concentration of C8, the eighth component of complement, the fraction of cells rendered permeable for the small polar fluorescent probe Lucifer Yellow was varied between 0.50 and 0.90. Under each condition the flux rate, k, of Lucifer Yellow was determined for a substantial number of ghosts. By analysing the sample population distribution of k the flux rate k1 of ghosts wit…

Synthesis and In Vitro Evaluation of Defined HPMA Folate Conjugates: Influence of Aggregation on Folate Receptor (FR) Mediated Cellular Uptake

2010

In this article we report the synthesis and in vitro evaluation of well-defined, folate functionalized and fluorescently labeled polymers based on the clinically approved N-(2-hydroxypropyl)-methacrylamide (HPMA). The polymers were prepared applying the RAFT polymerization method as well as the reactive ester approach. The molecular weights of the polymers synthesized were around 15 and 30 kDa. The total content of conjugated folate varied from 0, 5, and 10 mol %. The cellular uptake of these polymers was investigated in the folate receptor (FR)-positive human nasopharyngeal epidermal carcinoma (KB-3-1) and FR-negative human lung epithelial carcinoma (A549) cancer cell lines. In FR-positive…