Search results for "SCRIB"

showing 10 items of 249 documents

Asthma - The Construction of the Masculine Body

1994

This article focuses on understanding the social construction of male identity in Finland in the 1960s and 1970s. Sporting experiences of the author are used as material for memory-work (Erinnerungsarbeit), the key experience here being illness (Asthma). By writing through it, the author thematizes the healthy, sporting, and disciplined body inscribed in hegemonic masculinity.

Male identitySociology and Political Science05 social sciencesGender studies030229 sport sciencesSocial constructionismKey (music)03 medical and health sciences0302 clinical medicine0502 economics and businessSociology050212 sport leisure & tourismSocial Sciences (miscellaneous)Hegemonic masculinityInscribed figureInternational Review for the Sociology of Sport
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Beta‐blockers withdrawal in patients with heart failure with preserved ejection fraction and chronotropic incompetence: Effect on functional capacity…

2020

Abstract Background The pathophysiology of heart failure with preserved ejection fraction (HFpEF) is complex and multifactorial. Chronotropic incompetence (ChI) has emerged as a crucial pathophysiological mechanism. Beta‐blockers, drugs with negative chronotropic effects, are commonly used in HFpEF, although current evidence does not support its routine use in these patients. Hypothesis We postulate beta‐blockers may have deleterious effects in HFpEF and ChI. This work aims to evaluate the short‐term effect of beta‐blockers withdrawal on functional capacity assessed by the maximal oxygen uptake (peakVO2) in patients with HFpEF and ChI. Methods This is a prospective, crossover, randomized (1…

MaleChronotropicheart failure with preserved ejection fractionmedicine.medical_specialtyRandomizationchronotropic incompetenceAdrenergic beta-AntagonistsTrial Designs030204 cardiovascular system & hematologyVentricular Function Leftlaw.inventionBenzodiazepines03 medical and health sciences0302 clinical medicineQuality of lifeRandomized controlled triallawInternal medicinemedicineHumansMulticenter Studies as TopicProspective Studies030212 general & internal medicineRandomized Controlled Trials as TopicHeart FailureDose-Response Relationship Drugbusiness.industryVO2 maxStroke VolumeGeneral Medicineexercise capacityquality of lifeResearch DesignSample size determinationCardiologyFemaleDeprescribingCardiology and Cardiovascular MedicineHeart failure with preserved ejection fractionbusiness
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Prevalence and appropriateness of drug prescriptions for peptic ulcer and gastro-esophageal reflux disease in a cohort of hospitalized elderly

2011

Abstract Background Proton pump inhibitors (PPI) are among the most commonly prescribed medicines and their overuse is widespread in both primary and secondary care. Inappropriate prescription is of particular concern among elderly patients, who have often multiple comorbidities and need many drugs. Methods We evaluate the appropriateness of drugs for peptic ulcer or gastro-esophageal reflux disease (GERD) in a sample of elderly patients (65 years old or older) at admission and discharge in 38 internal medicine wards between January 2008 and December 2008, according to the presence of specific conditions or gastro-toxic drug combinations. Results Among 1155 patients eligible for the analysi…

MaleDrugmedicine.medical_specialtySettore MED/09 - Medicina Internamedia_common.quotation_subjectInappropriate PrescribingDiseaseappropriatenesselderly patientselderlyGastroenterologyCohort StudiesPharmacotherapyInternal medicineappropriateness; elderly; elderly patients; inappropriate prescription; proton pump inhibitorsPrevalenceInternal MedicinemedicineHumansMedical prescriptionpeptic ulcerAgedmedia_commonAged 80 and overSettore MED/12 - GastroenterologiaEvidence-Based Medicinebusiness.industrymedicine.diseaseSettore MED/45 - Scienze Infermieristiche Generali Cliniche E Pediatrichedigestive system diseasesdrug therapy)inappropriate prescriptionConcomitantCohortGastroesophageal Refluxpeptic ulcer; drug therapy); Prevalence; hospitalization; elderlyGERDDrug Therapy CombinationFemaleGuideline Adherenceproton pump inhibitorsbusinessProton pump inhibitors Appropriateness ElderlyhospitalizationCohort studyEuropean Journal of Internal Medicine
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Baraitser-Winter cerebrofrontofacial syndrome : Delineation of the spectrum in 42 cases

2015

International audience; Baraitser-Winter, Fryns-Aftimos and cerebrofrontofacial syndrome types 1 and 3 have recently been associated with heterozygous gain-of-function mutations in one of the two ubiquitous cytoplasmic actin-encoding genes ACTB and ACTG1 that encode beta- and gamma-actins. We present detailed phenotypic descriptions and neuroimaging on 36 patients analyzed by our group and six cases from the literature with a molecularly proven actinopathy (9 ACTG1 and 33 ACTB). The major clinical anomalies are striking dysmorphic facial features with hypertelorism, broad nose with large tip and prominent root, congenital non-myopathic ptosis, ridged metopic suture and arched eyebrows. Iris…

MaleMicrocephalyPathologyCraniofacial abnormality[SDV]Life Sciences [q-bio]MedizinGYRAL MALFORMATIONSCraniofacial AbnormalitiesFUNCTIONAL DIVERSITY0302 clinical medicinePtosisGene OrderGenetics(clinical)HypertelorismNon-U.S. Gov'tChildGenetics (clinical)ArthrogryposisDystonia0303 health sciencesResearch Support Non-U.S. Gov'tAnatomy3. Good healthPhenotypeChild PreschoolFemalemedicine.symptomAbnormalitiesMultipleRare cancers Radboud Institute for Health Sciences [Radboudumc 9]Adultmedicine.medical_specialtyAPPARENTLY UNDESCRIBED SYNDROMEAdolescentLissencephalyBiologyResearch SupportArticle03 medical and health sciencesYoung AdultSDG 3 - Good Health and Well-beingmedicineGeneticsJournal ArticleHumansAbnormalities MultiplePreschool030304 developmental biologySHALLOW ORBITSNeurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7]GAMMA-ACTINPachygyriaFaciesmedicine.diseaseIRIS COLOBOMAActinsBETA-ACTINAbnormalities Multiple; Actins; Adolescent; Adult; Amino Acid Substitution; Child; Child Preschool; Craniofacial Abnormalities; Facies; Female; Gene Order; Genetic Loci; Humans; Male; Mutation; Phenotype; Young AdultAmino Acid SubstitutionGenetic LociFACIAL SYNDROMEMutation030217 neurology & neurosurgeryMENTAL-RETARDATIONGROWTH-RETARDATION
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ITS-2 rDNA sequencing of Gnathostoma species (Nematoda) and elucidation of the species causing human gnathostomiasis in the Americas.

2000

From several gnathostome species the complete internal transcribed spacer ITS-2 ribosomal DNA (rDNA) repeat sequence and a fragment of the 5.8S rDNA were obtained by direct polymerase chain reaction cycle-sequencing and silver-staining methods. The size of the complete ITS-1 sequence in agarose gel electrophoresis was also obtained. The ITS-2 enabled the differentiation of Gnathostoma spinigerum from Thailand and Gnathostoma binucleatum from Mexico and Ecuador and confirmed the validity of the latter. Gnathostoma turgidum, Gnathostoma sp. I (=Gnathostoma procyonis sensu Almeyda-Artigas et al., 1994), and Gnathostoma sp. II (=G. turgidum sensu Foster, 1939 pro parte), all from Mexico, proved…

MaleMolecular Sequence DataSpirurida InfectionsBiologyGnathostoma spinigerumDNA RibosomalPolymerase Chain Reactionlaw.inventionDogsSensulawConsensus SequencemedicineAnimalsHumansInternal transcribed spacerRibosomal DNAGnathostomaMexicoEcology Evolution Behavior and SystematicsPolymerase chain reactionRepetitive Sequences Nucleic AcidGeneticsGnathostomiasisGnathostomaElectrophoresis Agar GelBase SequenceFishesSpacer DNAOpossumsDNA Helminthmedicine.diseasebiology.organism_classificationRNA Ribosomal 5.8SParasitologyFemaleRaccoonsEcuadorSequence AlignmentThe Journal of parasitology
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Finding of Parastrongylus cantonensis (Chen, 1935) in Rattus rattus in Tenerife, Canary Islands (Spain).

2010

Parastrongylus cantonensis is a parasite of murid rodents that can infect humans and cause health problems as eosinophilic meningitis. Although it is endemic in south Asia, the Pacific islands, Australia, USA, and a few Caribbean islands, it has been extended to new geographical regions. In the Canary Islands (Spain) a survey of helminths of Rattus rattus, Rattus norvegicus and Mus musculus domesticus was carried out. Furthermore, five species of molluscs were examined for nematode larvae to determine whether they are potential intermediate hosts of P. cantonensis. Nematodes were found in the lungs of 15% of 67 R. rattus examined in Tenerife, one of the four studied islands, with a prevalen…

MaleNematodaVeterinary (miscellaneous)Molecular Sequence DataZoologyHelminth geneticsBiologyDNA RibosomalRodent DiseasesMiceDNA Ribosomal SpacermedicinePrevalenceRNA Ribosomal 18SHelminthsParasite hostingAnimalsCluster AnalysisInternal transcribed spacerMolluscaLungPhylogenyStrongylida InfectionsCaribbean islandBase SequenceAngiostrongylus cantonensisSequence Analysis DNARibosomal RNADNA Helminthmedicine.diseasebiology.organism_classificationRatsInfectious DiseasesMolluscaSpainInsect ScienceAngiostrongyliasisParasitologyFemaleSequence AlignmentActa tropica
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Appropriateness of oral anticoagulant therapy prescription and its associated factors in hospitalized older people with atrial fibrillation

2018

Aims: Although oral anticoagulants (OACs) are effective in preventing stroke in older people with atrial fibrillation (AF), they are often underused in this particularly high-risk population. The aim of the present study was to assess the appropriateness of OAC prescription and its associated factors in hospitalized patients aged 65 years or older. Methods: Data were obtained from the retrospective phase of Simulation-based Technologies to Improve the Appropriate Use of Oral Anticoagulants in Hospitalized Elderly Patients With Atrial Fibrillation (SIM-AF) study, held in 32 Italian internal medicine and geriatric wards. The appropriateness of OAC prescription was assessed, grouping patients …

MaleOralappropriateness of prescriptionappropriateness of prescription atrial fibrillation internal medicine geriatric wards older patients oral anticoagulantSocio-culturaleAdministration OralHemorrhageInappropriate PrescribingDrug Prescriptionsinternal medicine and geriatric wardDose-Response Relationshipolder patientRisk Factorsoral anticoagulant80 and overHumansatrial fibrillationPharmacology (medical)Prospective StudiesAgedRetrospective StudiesAged 80 and overPharmacologygeriatric wardsDose-Response Relationship DrugSettore MED/09 - MEDICINA INTERNAAge FactorsAnticoagulantsinternal medicine and geriatric wardsOriginal Articlesolder patientsappropriateness of prescription; atrial fibrillation; internal medicine and geriatric wards; older patients; oral anticoagulant;appropriateness of prescription; atrial fibrillation; internal medicine and geriatric wards; older patients; oral anticoagulant; Pharmacology; Pharmacology (medical)Strokeinternal medicineappropriateness of prescription; atrial fibrillation; internal medicine and geriatric wards; older patients; oral anticoagulantAdministrationFemaleDrug
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Comparing Long-Acting Antipsychotic Discontinuation Rates Under Ordinary Clinical Circumstances: A Survival Analysis from an Observational, Pragmatic…

2021

Background Recent guidelines suggested a wider use of long-acting injectable antipsychotics (LAI) than previously, but naturalistic data on the consequences of LAI use in terms of discontinuation rates and associated factors are still sparse, making it hard for clinicians to be informed on plausible treatment courses. Objective Our objective was to assess, under real-world clinical circumstances, LAI discontinuation rates over a period of 12 months after a first prescription, reasons for discontinuation, and associated factors. Methods The STAR Network ‘Depot Study’ was a naturalistic, multicentre, observational prospective study that enrolled subjects initiating a LAI without restrictions …

MalePediatricsrespectively)0302 clinical medicineDelayed-Action PreparationBrief Psychiatric Rating ScalePharmacology (medical)he STAR Network ‘Depot Study’ prospectively followed 394 subjects initiating treatment with long-acting injections (LAIs) of antipsychotics under naturalistic conditions for 12 months. LAI discontinuation was frequent in everyday clinical practice in ItalyOriginal Research ArticleProspective StudiesProspective cohort studytreatmentMental DisordersHazard ratiowhereas more than half of participants initiating risperidone LAI and olanzapine LAI discontinued during the 12 months of follow-up (51.4 and 62.5%Psychiatric Status Rating ScaleMiddle Agedside efectsPsychiatry and Mental healthItalyMental DisorderFemalehe STAR Network ‘Depot Study’ prospectively followed 394 subjects initiating treatment with long-acting injections (LAIs) of antipsychotics under naturalistic conditions for 12 months. LAI discontinuation was frequent in everyday clinical practice in Italy occurring in almost 40% of the entire sample; side efects participant refusal to continue LAIs and LAIs no longer being required were the most frequently reported reasons for discontinuation. Paliperidone LAI and aripiprazole LAI were the least discontinued medications (33.9 and 35.4% respectively) whereas more than half of participants initiating risperidone LAI and olanzapine LAI discontinued during the 12 months of follow-up (51.4 and 62.5% respectively). In multivariate analysis being prescribed olanzapine LAI and poor medication adherence at baseline were signifcantly associated with higher discontinuation risk.HumanAntipsychotic Agentsmedicine.drugPsychopathologyAdultmedicine.medical_specialtyDiscontinuationFollow-Up StudieMedication Adherence03 medical and health sciencesmedicineHumansPaliperidoneAdverse effectSettore MED/25 - Psichiatriadiscontinuation ratesPsychiatric Status Rating Scalesrespectively). In multivariate analysisbusiness.industryLong-Acting Antipsychoticlong-acting injectable antipsychoticsSurvival AnalysisConfidence intervalparticipant refusal to continue LAIs and LAIs no longer being required were the most frequently reported reasons for discontinuation. Paliperidone LAI and aripiprazole LAI were the least discontinued medications (33.9 and 35.4%030227 psychiatryDiscontinuationProspective StudieAntipsychotic Agentoccurring in almost 40% of the entire sampleDelayed-Action PreparationsNeurology (clinical)business030217 neurology & neurosurgerybeing prescribed olanzapine LAI and poor medication adherence at baseline were signifcantly associated with higher discontinuation riskFollow-Up Studies
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Clusters of sleep apnoea phenotypes: A large pan-European study from the European Sleep Apnoea Database (ESADA)

2021

Background and objective: To personalize OSA management, several studies have attempted to better capture disease heterogeneity by clustering methods. The aim of this study was to conduct a cluster analysis of 23 000 OSA patients at diagnosis using the multinational ESADA. Methods: Data from 34 centres contributing to ESADA were used. An LCA was applied to identify OSA phenotypes in this European population representing broad geographical variations. Many variables, including symptoms, comorbidities and polysomnographic data, were included. Prescribed medications were classified according to the ATC classification and this information was used for comorbidity confirmation. Results: Eight cl…

MalePulmonary and Respiratory MedicineDatabases FactualTreatment adherenceinternational databaseComorbidityDiseasecomputer.software_genre03 medical and health sciencesSleep Apnea Syndromes0302 clinical medicinePan europeanHumansMedicinecluster analysis ; international database ; personalized medicine ; phenotypes ; sleep apnoea.030212 general & internal medicineMedical prescriptionPrescribed medicationsComputingMilieux_MISCELLANEOUSSleep Apnea Obstructive[STAT.AP]Statistics [stat]/Applications [stat.AP]Databasebusiness.industryphenotypesEuropean populationpersonalized medicinemedicine.diseaseComorbidity3. Good healthPhenotype030228 respiratory systemFemalePersonalized medicinebusinesscomputersleep apnoea[SDV.MHEP]Life Sciences [q-bio]/Human health and pathologycluster analysis
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Inadequate empirical antimicrobial treatment in older people with bacteremic urinary tract infection who reside in nursing homes: A multicenter prosp…

2019

AIM The aim of the study was to determine the rate of inadequate empirical antimicrobial treatment in older nursing home residents with bacteremic urinary tract infection and its influence on prognosis. METHODS We carried out a multicentric prospective observational study in five Spanish hospitals. Patients aged >65 years with pyelonephritis or urinary sepsis with bacteremia were included. Clinical characteristics, the percentage of inadequate empirical antibiotic treatment, length of hospital stay and mortality were evaluated. RESULTS A total of 181 patients, 54.7% women, were included in the study, and 35.9% of the patients came from nursing homes. These patients had higher percentages of…

Malemedicine.medical_specialtyMultivariate analysismedicine.drug_classUrinary systemAntibioticsBacteremiaInappropriate PrescribingSepsisInternal medicinemedicineHomes for the AgedHumansProspective StudiesAgedAged 80 and overbusiness.industrymedicine.diseaseAntimicrobialAnti-Bacterial AgentsNursing HomesSpainBacteremiaUrinary Tract InfectionsObservational studyFemaleNursing homesbusinessGeriatricsgerontology internationalReferences
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