Search results for "SCS"
showing 10 items of 157 documents
The Immunomodulatory Properties of the Human Amnion-Derived Mesenchymal Stromal/Stem Cells Are Induced by INF-γ Produced by Activated Lymphomonocytes…
2020
Human mesenchymal stromal/stem cells (MSCs), being immunoprivileged and having immunomodulatory ability, represent a promising tool to be applied in the field of regenerative medicine. Based on numerous in vitro evidences, the immunological effects of MSCs on immune cells could depend on different mechanisms as cell-to-cell contact and paracrine signals. Furthermore, recent studies have shown that the immunomodulatory activity of MSCs is initiated by activated immune cells; thus, their interaction represents a potential homeostatic mechanism by which MSCs regulate the immune response. MSCs also release exosomes able to give different effects, in a paracrine manner, by influencing inflammato…
Fold formation at the compartment boundary of Drosophila wing requires Yki signaling to suppress JNK dependent apoptosis
2016
AbstractCompartment boundaries prevent cell populations of different lineage from intermingling. In many cases, compartment boundaries are associated with morphological folds. However, in the Drosophila wing imaginal disc, fold formation at the anterior/posterior (A/P) compartment boundary is suppressed, probably as a prerequisite for the formation of a flat wing surface. Fold suppression depends on optomotor-blind (omb). Omb mutant animals develop a deep apical fold at the A/P boundary of the larval wing disc and an A/P cleft in the adult wing. A/P fold formation is controlled by different signaling pathways. Jun N-terminal kinase (JNK) and Yorkie (Yki) signaling are activated in cells alo…
The shell of the invasive bivalve species Dreissena polymorpha: biochemical, elemental and textural Investigations.
2016
28 pages; International audience; The zebra mussel Dreissena polymorpha is a well-established invasive model organism. Although extensively used in environmental sciences, virtually nothing is known of the molecular process of its shell calcification. By describing the microstructure, geochemistry and biochemistry/proteomics of the shell, the present study aims at promoting this species as a model organism in biomineralization studies, in order to establish a bridge with ecotoxicology, while sketching evolutionary conclusions. The shell of D. polymorpha exhibits the classical crossed-lamellar/complex crossed lamellar combination found in several heterodont bivalves, in addition to an extern…
Descripción de un nuevo limácido de Menorca (Islas Baleares): Gigantomilax (Vitrinoides) benjaminus sp. n. (Gastropoda, Pulmonata)
2008
We describe a new endemic limacid slug, Gigantomilax (Vitrinoides) benjaminus n. sp. and we compare it with the nearest species, particularly with Gigantomilax (V.) majoricensis, another Balearic endemism. Characteristic features of this new species include its small size, translucid and smooth body, and totally grey dorsum with no bands or spots. The reproductive system shows a well developed vas deferens surrounded by the distal part of prostatic gland, a thin penial retractor muscle, swollen prostate and small distal genitalia. The recent redescription of Limax majoricensis by Wiktor et al. (2007) is discussed and we consider that these authors refer to G. benjaminus n. sp., and so we de…
Spectral and timing properties of IGR J00291+5934 during its 2015 outburst
2016
We report on the spectral and timing properties of the accreting millisecond X-ray pulsar IGR J00291+5934 observed by XMM-Newton and NuSTAR during its 2015 outburst. The source is in a hard state dominated at high energies by a comptonization of soft photons ($\sim0.9$ keV) by an electron population with kT$_e\sim30$ keV, and at lower energies by a blackbody component with kT$\sim0.5$ keV. A moderately broad, neutral Fe emission line and four narrow absorption lines are also found. By investigating the pulse phase evolution, we derived the best-fitting orbital solution for the 2015 outburst. Comparing the updated ephemeris with those of the previous outbursts, we set a $3��$ confidence leve…
Broad-band spectral analysis of the accreting millisecond X-ray pulsar SAX J1748.9-2021
2016
We analyzed a 115 ks XMM-Newton observation and the stacking of 8 days of INTEGRAL observations, taken during the raise of the 2015 outburst of the accreting millisecond X-ray pulsar SAX J1748.9-2021. The source showed numerous type-I burst episodes during the XMM-Newton observation, and for this reason we studied separately the persistent and burst epochs. We described the persistent emission with a combination of two soft thermal components, a cold thermal Comptonization component (~2 keV) and an additional hard X-ray emission described by a power-law (photon index ~2.3). The continuum components can be associated with an accretion disc, the neutron star (NS) surface and a thermal Compton…
Aperiodic variability of low-mass X-ray binaries at very low frequencies
2003
We have obtained discrete Fourier power spectra of a sample of persistent low-mass neutron-star X-ray binaries using long-term light curves from the All Sky Monitor on board the Rossi X-ray Timing Explorer. Our aim is to investigate their aperiodic variability at frequencies in the range 1 x 10^{-7}-5 x 10^{-6} Hz and compare their properties with those of the black-hole source Cyg X-1. We find that the classification scheme that divides LMXBs into Z and atoll sources blurs at very low frequencies. Based on the long-term (~ years) pattern of variability and the results of power-law fits (P ~ v^{-a}) to the 1 x 10^{-7}-5 x 10^{-6} Hz power density spectra, low-mass neutron-star binaries fall…
Accrétion et éjection dans les systèmes binaires X transitoires à trous noirs : le cas de GRS 1716-249
2020
I buchi neri transienti (BHT) sono tra le sorgenti con emissione ai raggi X più luminose della galassia. Grazie all’elevato flusso in banda X e alla loro alta variabilità temporale. queste sorgenti offrono un’opportunità unica per studiare la fisica dell’accrescimento in straordinareie condizioni fisiche. I BHT mostrano episodici outburst caratterizzati da diverse luminosità in banda X e γ, diverse forme spettrali e proprietà della variabilità temporale. L’obiettivo di questa tesi è lo studio della geometria, dei meccanismi e dei processi fisici coinvolti nell’emissione del buco nero transiente GRS 716-249. Di seguito presento l’analisi spettrale e temporale delle osservazioni della GRS 171…
Wind-luminosity evolution in NLS1 AGN 1H 0707−495
2021
Ultra-fast outflows (UFOs) have been detected in the high-quality X-ray spectra of a number of active galactic nuclei (AGN) with fairly high accretion rates and are thought to significantly contribute to the AGN feedback. After a decade of dedicated study, their launching mechanisms and structure are still not well understood, but variability techniques may provide useful constraints. In this work, therefore, we perform a flux-resolved X-ray spectroscopy on a highly accreting and variable NLS1 AGN, 1H 0707-495, using all archival XMM-Newton observations to study the structure of the UFO. We find that the wind spectral lines weaken at higher luminosities, most likely due to an increasing ion…
Role of p16INK4a and BMI-1 in oxidative stress-induced premature senescence in human dental pulp stem cells
2017
Human dental pulp stem cells (hDPSCs) are a source for cell therapy. Before implantation, an in vitro expansion step is necessary, with the inconvenience that hDPSCs undergo senescence following a certain number of passages, loosing their stemness properties. Long-term in vitro culture of hDPSCs at 21% (ambient oxygen tension) compared with 3–6% oxygen tension (physiological oxygen tension) caused an oxidative stress-related premature senescence, as evidenced by increased β-galactosidase activity and increased lysil oxidase expression, which is mediated by p16INK4a pathway. Furthermore, hDPSCs cultured at 21% oxygen tension underwent a downregulation of OCT4, SOX2, KLF4 and c-MYC factors, w…