Search results for "SCS"
showing 10 items of 157 documents
The jets and disc of SS 433 at super-Eddington luminosities
2009
We examine the jets and the disc of SS 433 at super-Eddington luminosities with 600 times Eddington critical accretion rate by time-dependent two-dimensional radiation hydrodynamical calculations, assuming alpha-model for the viscosity. One-dimensional supercritical accretion disc models with mass loss or advection are used as the initial configurations of the disc. As a result, from the initial advective disc models with alpha =0.001 and 0.1, we obtain the total luminosities 2.5x10^{40} and 2.0x10^{40} erg/s. The total mass-outflow rates are 4x10^{-5} and 10^{-4} solar-mass/yr and the rates of the relativistic axial outflows in a small half opening angle of 1 degree are about 10^{-6} solar…
Testing Rate Dependent corrections on timing mode EPIC-pn spectra of the accreting Neutron Star GX 13+1
2014
When the EPIC-pn instrument on board XMM-Newton is operated in Timing mode, high count rates (>100 cts/s) of bright sources may affect the calibration of the energy scale, resulting in a modification of the real spectral shape. The corrections related to this effect are then strongly important in the study of the spectral properties. Tests of these calibrations are more suitable in sources which spectra are characterised by a large number of discrete features. Therefore, in this work, we carried out a spectral analysis of the accreting Neutron Star GX 13+1, which is a dipping source with several narrow absorption lines and a broad emission line in its spectrum. We tested two different co…
The pulse profile and spin evolution of the accreting pulsar in Terzan 5, IGR J17480-2446, during its 2010 outburst
2012
(abridged) We analyse the spectral and pulse properties of the 11 Hz transient accreting pulsar, IGR J17480-2446, in the globular cluster Terzan 5, considering all the available RXTE, Swift and INTEGRAL observations performed between October and November, 2010. By measuring the pulse phase evolution we conclude that the NS spun up at an average rate of =1.48(2)E-12 Hz/s, compatible with the accretion of the Keplerian angular momentum of matter at the inner disc boundary. Similar to other accreting pulsars, the stability of the pulse phases determined by using the second harmonic component is higher than that of the phases based on the fundamental frequency. Under the assumption that the sec…
Unveiling the disc structure in ultraluminous X-ray source NGC 55 ULX-1
2022
Ultraluminous X-ray sources (ULXs) are the most extreme among X-ray binaries in which the compact object, a neutron star or a black hole, accretes matter from the companion star, and exceeds a luminosity of 1039 ergs−1 in the X-ray energy band alone. Despite two decades of studies, it is still not clear whether ULX spectral transitions are due to stochastic variability in the wind or variations in the accretion rate or in the source geometry. The compact object is also unknown for most ULXs. In order to place constraints on to such scenarios and on the structure of the accretion disc, we studied the temporal evolution of the spectral components of the variable source NGC 55 ULX-1. Using rec…
MAXI J1957+032: a new accreting millisecond X-ray pulsar in an ultra-compact binary
2022
The detection of coherent X-ray pulsations at ~314 Hz (3.2 ms) classifies MAXI J1957+032 as a fast-rotating, accreting neutron star. We present the temporal and spectral analysis performed using NICER observations collected during the latest outburst of the source. Doppler modulation of the X-ray pulsation revealed the ultra-compact nature of the binary system characterised by an orbital period of ~1 hour and a projected semi-major axis of 14 lt-ms. The neutron star binary mass function suggests a minimum donor mass of 1.7e-2 Msun, assuming a neutron star mass of 1.4 Msun and a binary inclination angle lower than 60 degrees. This assumption is supported by the lack of eclipses or dips in th…
Mutant p53 gain of function can be at the root of dedifferentiation of human osteosarcoma MG63 cells into 3AB-OS cancer stem cells
2014
Osteosarcoma is a highly metastatic tumor affecting adolescents, for which there is no second-line chemotherapy. As suggested for most tumors, its capability to overgrow is probably driven by cancer stem cells (CSCs), and finding new targets to kill CSCs may be critical for improving patient survival. TP53 is the most frequently mutated tumor suppressor gene in cancers and mutant p53 protein (mutp53) can acquire gain of function (GOF) strongly contributing to malignancy. Studies thus far have not shown p53-GOF in osteosarcoma. Here, we investigated TP53 gene status/role in 3AB-OS cells-a highly aggressive CSC line previously selected from human osteosarcoma MG63 cells-to evaluate its involv…
Síntesis de los estudios sobre moluscos continentales neógenos del sector septentrional de la Depresión de Teruel: período 1775-1998
2006
Se recopila y analiza la información que se considera más relevante y se encuentra contenida en los estudios realizados sobre el registro fósil de los moluscos neógenos del sector septentrional de la Depresión de Teruel en el período comprendido entre los años 1775 y 1998. Se contabilizan, por una parte, el número total de taxones diferentes mencionados en cada trabajo y, por otra, sólo el número de citas efectuadas a nivel de especie en cada uno de ellos. Estas últimas se organizan en tres categorías que reciben el nombre de citas nuevas, especies nuevas y citas repetidas. Se propone, a partir de la información contenida en cada trabajo, el número de taxones contemplados, y la tipología de…
Inbreeding does not alter the response to an experimental heat wave in a freshwater snail
2019
Global climate change affects natural populations of many species by increasing the average temperature and the frequency of extreme weather events (e.g. summer heat waves). The ability of organisms to cope with these environmental changes can, however, depend on their genetic properties. For instance, genetic load owing to inbreeding could alter organisms’ responses to climate change-mediated environmental changes but such effects are often overlooked. We investigated the effects of an experimental heat wave (25°C versus 15°C) on life history (reproduction, size) and constitutive immune defence traits (phenoloxidase-like and antibacterial activity of haemolymph) in relation to inbreeding b…
SCS Curve Number and Green-Ampt Infiltration Models
2019
Soil Conservation Service curve number (SCS-CN) and Green-Ampt (GA) infiltration models are probably the most applied equations in practical hydrology to compute the amount of direct runoff from rainfall. Both models are very simple, require few parameters, and present drawbacks and advantages. The empirical CN model concentrates the infiltration effect in the curve number and in the so-called soil hydrological groups, which have been widely characterized for different soil types, land cover, and antecedent soil moisture conditions (ASMCs), although the latter was considered ambiguous, whereas soil hydrological characteristics, including ASMC, are taken into account for the simplified physi…
The Challenge of Using CB-HSCs As Source for Gene Therapy: Lentiviral Vector Transduction, Phenotypic Characterization and Global Gene Expression Pro…
2015
Abstract Introduction: Genetic modification of autologous hematopoietic stem and progenitor cells (HSPC) is a promising clinical intervention to cure inherited monogenic diseases. Successful gene therapy trials have already been conducted using CD34+ cells from bone marrow and from mobilized peripheral blood. In this regard, cord blood (CB) represents an attractive source of HSCs due to its high concentration of high proliferative HSPC and increased susceptibility to be transduced by lentiviral vectors. Unfortunately, the major disadvantage is the limited number of HSC in the CB collection. Consequently, ex-vivo expansion of CB-HSC is desirable to extend clinical applications. Purposes: To …