Search results for "SCS"

Crida, 1609, 12, 05

Com a tít. el començament del text Caplletra ornada Sign. : [ ]1

Crida, 1610, 01, 09

Com a tít. el començament del text Caplletra ornada Sign.: [ ]2 Reclams

Ara ojats queus fan a saber de part de la S.C.R.Magestat. Y per aquella De part del ... senyor Don Gomez Suarez de Figueroa y Cardona .... Lloctinent…

1616

Caplletra historiada Sign.: [ ]2

Ara ojats queus notifiquen y fan a saber de part de la S.C.R. Magestad. E per aquella De part del ... señor Don Henrique de Auila y Guzman Marques d…

1625

Capital grav. Sign.: [ ]2 Reclams

Pragmatica Real sobre cosas tocantes al asiento general del Reyno de Valencia, por razon de la Expulsión de los Moriscos, y reducción de los Censal…

1614

La Pragmàtica datada en Madrid el 2 d'Abril de 1614 i publicada a València el dia 15 del mateix mes per manament de D. Luis Carrillo de Toledo Marqués de Carazena, Lloctinent y Capità general Escut reial xil. a la port. Caplletra grav. Sign. : A10 Reclams

Ara ojats queus notifiquen, y fau a saber de part de la S.C.R. Magestat, E per aquella de part del ... Senyor Don Luys Carrillo de Toledo Marques de …

1614

Sign.: [ ]2

Por Lorenzo Bov de Peñarroja generoso, señor de los lugares de Cenija, Benimalull, y Tormos, &c. Con el Marqves de Ariza, señor de las baronias de Be…

Signat al final: "Sylvestro Blanco" Sign.: A-D2, E1

Drug connectivity mapping and functional analysis reveal therapeutic small molecules that differentially modulate myelination

2022

Disruption or loss of oligodendrocytes (OLs) and myelin has devastating effects on CNS function and integrity, which occur in diverse neurological disorders, including Multiple Sclerosis (MS), Alzheimer’s disease and neuropsychiatric disorders. Hence, there is a need to develop new therapies that promote oligodendrocyte regeneration and myelin repair. A promising approach is drug repurposing, but most agents have potentially contrasting biological actions depending on the cellular context and their dose-dependent effects on intracellular pathways. Here, we have used a combined systems biology and neurobiological approach to identify compounds that exert positive and negative effects on olig…

Rôle du transporteur d'acides aminés Minidiscs dans le fonctionnement du système nerveux chez Drosophila melanogaster

2015

Amino acids have many functions in the body in addition to their role as basic constituents of proteins. They can for example serve as a neurotransmitter or signal for the activation of intracellular pathways. Carriers of the SLC protein family facilitate their path through the plasma membrane. The heterodimeric amino acid transporters HAT belong to SLC proteins. HAT are composed of a light chain SLC7 ensuring the specificity of transport and a heavy chain SLC3 involved in the addressing of the protein complex to the plasma membrane. My thesis focused on studying the role of a SLC7 homologue in drosophila, Minidiscs (Mnd), in the functioning of the nervous system. Mnd might belong to system…

Nemo regulates cell dynamics and represses the expression of miple, a midkine/pleiotrophin cytokine, during ommatidial rotation

2013

AbstractOmmatidial rotation is one of the most important events for correct patterning of the Drosophila eye. Although several signaling pathways are involved in this process, few genes have been shown to specifically affect it. One of them is nemo (nmo), which encodes a MAP-like protein kinase that regulates the rate of rotation throughout the entire process, and serves as a link between core planar cell polarity (PCP) factors and the E-cadherin–β-catenin complex. To determine more precisely the role of nmo in ommatidial rotation, live-imaging analyses in nmo mutant and wild-type early pupal eye discs were performed. We demonstrate that ommatidial rotation is not a continuous process, and …