Search results for "SDG"
showing 10 items of 655 documents
Polycystic ovary syndrome
2016
Polycystic ovary syndrome (PCOS) affects 5-20% of women of reproductive age worldwide. The condition is characterized by hyperandrogenism, ovulatory dysfunction and polycystic ovarian morphology (PCOM) - with excessive androgen production by the ovaries being a key feature of PCOS. Metabolic dysfunction characterized by insulin resistance and compensatory hyperinsulinaemia is evident in the vast majority of affected individuals. PCOS increases the risk for type 2 diabetes mellitus, gestational diabetes and other pregnancy-related complications, venous thromboembolism, cerebrovascular and cardiovascular events and endometrial cancer. PCOS is a diagnosis of exclusion, based primarily on the p…
Manipulating the alpha level cannot cure significance testing
2018
We argue that making accept/reject decisions on scientific hypotheses, including a recent call for changing the canonical alpha level from p = 0.05 to p = 0.005, is deleterious for the finding of new discoveries and the progress of science. Given that blanket and variable alpha levels both are problematic, it is sensible to dispense with significance testing altogether. There are alternatives that address study design and sample size much more directly than significance testing does; but none of the statistical tools should be taken as the new magic method giving clear-cut mechanical answers. Inference should not be based on single studies at all, but on cumulative evidence from multiple in…
Air pollution, residential greenness and metabolic dysfunction during early pregnancy in the infancia y medio ambiente (Inma) cohort
2021
Despite extensive study, the role of air pollution in gestational diabetes remains unclear, and there is limited evidence of the beneficial impact of residential greenness on metabolic dysfunction during pregnancy. We used data from mothers in the Spanish INfancia y Medio Ambiente (INMA) Project from 2003–2008. We obtained spatiotemporally resolved estimates of fine particulate matter (PM2.5) and nitrogen dioxide (NO2) exposures in early pregnancy and estimated residential greenness using satellite-based Normal Difference Vegetation Index (NDVI) within 100, 300 and 500 m buffers surrounding the mother’s residence. We applied logistic regression models to evaluate associations between each o…
Measurement of the Spin of the Ω− Hyperon
2006
A measurement of the spin of the Omega(-) hyperon produced through the exclusive process Xi(c)(0)--Omega(-)K(+) is presented using a total integrated luminosity of 116 fb(-1) recorded with the BABAR detector at the e(+)e(-) asymmetric-energy B factory at SLAC. Under the assumption that the Xi(c)(0) has spin 1/2, the angular distribution of the Lambda from Omega(-)--LambdaK(-) decay is inconsistent with all half-integer Omega(-) spin values other than 3/2. Lower statistics data for the process Omega(c)(0)--Omega(-)pi(+) from a 230 fb(-1) sample are also found to be consistent with Omega(-) spin 3/2. If the Xi(c)(0) spin were 3/2, an Omega(-) spin of 5/2 could not be excluded.
First observation of the doubly charmed baryon decay Ξcc++→Ξc+π+
2018
The doubly charmed baryon decay Ξcc++→Ξc+π+ is observed for the first time, with a statistical significance of 5.9σ, confirming a recent observation of the baryon in the Λc+K−π+π+ final state. The data sample used corresponds to an integrated luminosity of 1.7 fb−1, collected by the LHCb experiment in pp collisions at a center-of-mass energy of 13 TeV. The Ξcc++ mass is measured to be 3620.6±1.5(stat)±0.4(syst)±0.3(Ξc+) MeV/c2 and is consistent with the previous result. The ratio of branching fractions between the decay modes is measured to be [B(Ξcc++→Ξc+π+)×B(Ξc+→pK−π+)]/[B(Ξcc++→Λc+K−π+π+)×B(Λc+→pK−π+)]=0.035±0.009(stat)±0.003(syst).
Measurement of the c0 Baryon Lifetime
2018
We report a measurement of the lifetime of the $��_c^0$ baryon using proton-proton collision data at center-of-mass energies of 7 and 8~TeV, corresponding to an integrated luminosity of 3.0 fb$^{-1}$ collected by the LHCb experiment. The sample consists of about 1000 $��_b^-\to��_c^0��^-\bar��_�� X$ signal decays, where the $��_c^0$ baryon is detected in the $pK^-K^-��^+$ final state and $X$ represents possible additional undetected particles in the decay. The $��_c^0$ lifetime is measured to be $��_{��_c^0} = 268\pm24\pm10\pm2$ fs, where the uncertainties are statistical, systematic, and from the uncertainty in the $D^+$ lifetime, respectively. This value is nearly four times larger than, …
Study of W Boson Production in Association with Beauty and Charm
2015
The associated production of a W boson with a jet originating from either a light parton or heavy-flavor quark is studied in the forward region using proton-proton collisions. The analysis uses data corresponding to integrated luminosities of 1.0 and 2.0 fb[superscript -1] collected with the LHCb detector at center-of-mass energies of 7 and 8 TeV, respectively. The W bosons are reconstructed using the W → μν decay and muons with a transverse momentum, p[subscript T], larger than 20 GeV in the pseudorapidity range 2.0 20 GeV and 2.2 20 GeV. The fraction of W + jet events that originate from beauty and charm quarks is measured, along with the charge asymmetries of the W + b and W + c produ…
Proliferative verrucous leukoplakia; a critical appraisal of the diagnostic criteria
2012
Since its introduction in the literature in 1985, the term proliferative verrucous leukoplakia (PVL) has been the subject of an ongoing discussion with regard to its definition. Widespread or multifocal occurrence of oral leukoplakia is not just synonymous to PVL. In the present treatise the proposal is made to require the involvement of more than two oral oral subsites, a total added seizeof the leukoplakic areas of at least 3 centimeters, and a well documented period of at least five years of disease evolution being characterized by spreading and the occurrence of one or more recurrences in a previously treated area. Key words:Oral premalignant lesions, leukoplakia, verrucous leukoplakia.
Global, regional, and national levels and causes of maternal mortality during 1990-2013: A systematic analysis for the Global Burden of Disease Study…
2014
BACKGROUND: The fifth Millennium Development Goal (MDG 5) established the goal of a 75% reduction in the maternal mortality ratio (MMR; number of maternal deaths per 100,000 livebirths) between 1990 and 2015. We aimed to measure levels and track trends in maternal mortality, the key causes contributing to maternal death, and timing of maternal death with respect to delivery.METHODS: We used robust statistical methods including the Cause of Death Ensemble model (CODEm) to analyse a database of data for 7065 site-years and estimate the number of maternal deaths from all causes in 188 countries between 1990 and 2013. We estimated the number of pregnancy-related deaths caused by HIV on the basi…
Hepatitis C virus prevalence and level of intervention required to achieve the WHO targets for elimination in the European Union by 2030: a modelling…
2017
Background Hepatitis C virus (HCV) is a leading cause of liver-related morbidity and mortality worldwide. In the European Union (EU), treatment and cure of HCV with direct-acting antiviral therapies began in 2014. WHO targets are to achieve a 65% reduction in liver-related deaths, a 90% reduction of new viral hepatitis infections, and 90% of patients with viral hepatitis infections being diagnosed by 2030. This study assessed the prevalence of HCV in the EU and the level of intervention required to achieve WHO targets for HCV elimination. Methods We populated country Markov models for the 28 EU countries through a literature search of PubMed and Embase between Jan 1, 2000, and March 31, 201…