Search results for "SDG"
showing 10 items of 655 documents
Beta-Catenin mediates tumor-induced immunosuppression by inhibiting cross-priming of CD8(+) T cells
2014
Tumors activate -catenin in DCs to suppress CD8 immunity by inhibiting cross-priming; -catenin-suppressed CD8 immunity could be rescued by enhancing cross-priming. Whereas CD8(+) T cells are essential for anti-tumor immunity, tumors often evade CD8(+) T cell surveillance by immunosuppression. As the initiators of antigen-specific immune responses, DCs are likely to play a central role in regulating the balance between immunity and tolerance to tumor antigens and are specialized in their ability to cross-present exogenous tumor antigens on MHC class I molecules to initiate CD8(+) T cell immunity. However, it remains unclear whether and how tumors modulate DC functions to suppress CD8(+) T ce…
Open data from the first and second observing runs of advanced LIGO and advanced Virgo
2021
Abbot, Rich, et al. (Virgo and MAGIC Collaboration)
On the origin of the southern Permian Basin, Central Europe.
2000
A detailed study of the structural and stratigraphic evolution of the Southern Permian Basin during latest Carboniferous to Early Jurassic times, supported by quantitative subsidence analyses and forward basin modelling for 25 wells, leads us to modify the conventional model for the Rotliegend-Zechstein development of this basin. The Late Permian-Early Jurassic tectonic subsidence curves are typical for a Permian to Early Triassic extensional stage that is followed by thermal subsidence. However, a purely extensional model is extremely problematic because active faulting during this time is 'minor' and generally hard to document. Using inverse techniques to model the subsidence curves, we q…
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer
2013
Journal article TERT-locus SNPs and leukocyte telomere measures are reportedly associated with risks of multiple cancers. Using the Illumina custom genotyping array iCOGs, we analyzed ~480 SNPs at the TERT locus in breast (n = 103,991), ovarian (n = 39,774) and BRCA1 mutation carrier (n = 11,705) cancer cases and controls. Leukocyte telomere measurements were also available for 53,724 participants. Most associations cluster into three independent peaks. The minor allele at the peak 1 SNP rs2736108 associates with longer telomeres (P = 5.8 × 10!-7), lower risks for estrogen receptor (ER)-negative (P = 1.0 × 10!-8) and BRCA1 mutation carrier (P = 1.1 × 10!-5) breast cancers and altered promot…
The gut as reservoir of antibiotic resistance: microbial diversity of tetracycline resistance in mother and infant.
2011
The microbiota in the human gastrointestinal tract (GIT) is highly exposed to antibiotics, and may be an important reservoir of resistant strains and transferable resistance genes. Maternal GIT strains can be transmitted to the offspring, and resistances could be acquired from birth. This is a case study using a metagenomic approach to determine the diversity of microorganisms conferring tetracycline resistance (Tc(r)) in the guts of a healthy mother-infant pair one month after childbirth, and to investigate the potential for horizontal transfer and maternal transmission of Tc(r) genes. Fecal fosmid libraries were functionally screened for Tc(r), and further PCR-screened for specific Tc(r) …
Functional Brain Segmentation Using Inter-Subject Correlation in fMRI
2016
The human brain continuously processes massive amounts of rich sensory information. To better understand such highly complex brain processes, modern neuroimaging studies are increasingly utilizing experimental setups that better mimic daily‐life situations. A new exploratory data‐analysis approach, functional segmentation inter‐subject correlation analysis (FuSeISC), was proposed to facilitate the analysis of functional magnetic resonance (fMRI) data sets collected in these experiments. The method provides a new type of functional segmentation of brain areas, not only characterizing areas that display similar processing across subjects but also areas in which processing across subjects is h…
First Observation of Top Quark Production in the Forward Region
2015
Top quark production in the forward region in proton-proton collisions is observed for the first time. The W + b final state with W → μν is reconstructed using muons with a transverse momentum, p[subscript T], larger than 25 GeV in the pseudorapidity range 2.0 20 GeV. The results are based on data corresponding to integrated luminosities of 1.0 and 2.0 fb[superscript -1] collected at center-of-mass energies of 7 and 8 TeV by LHCb. The inclusive top quark production cross sections in the fiducial region are σ(top)[7 TeV] = 239 ± 53(stat) ± 33(syst) ± 24(theory) fb, σ(top)[8 TeV] = 289 ± 43(stat) ± 40(syst) ± 29(theory) fb.These results, along with the observed differential yields and c…
Development of accurate mass spectrometric routine and reference methods for the determination of trace amounts of iridium and rhodium in photographi…
1999
For the determination of trace amounts of iridium and rhodium in photographic emulsions different sample treatment procedures were coupled with inductively coupled plasma mass spectrometry (ICP-MS) and, for iridium, also with negative thermal ionisation isotope dilution mass spectrometry (NTI-IDMS) and ICP-IDMS. IDMS determinations of iridium were carried out using an enriched 191Ir spike solution. Elimination of the silver matrix was established for both mass spectrometric methods, which prevents corresponding memory effects in the ICP-MS system and is essential for the formation of IrO2 - thermal ions, respectively. For NTI-MS measurements, the gelatine matrix of the emulsion must also be…
Trace element behavior in the fluidized bed gasification of solid recovered fuels
2013
Gasification of biomass and recycled fuels is of particular interest for the efficient production of power and heat. Trace elements present as impurities in the product gas should be removed very efficiently. The objective of this work has been to develop and test thermodynamic models for the reactions of trace elements with chlorine and sulfur in the gasification processes of recycled fuels. In particular, the chemical reactions of trace elements with main thermochemical conversion products, main ash components, and bed and sorbent material are implemented into the model. The possibilities of gas cleaning devices in condensing and removing the trace element compounds are studied by establi…
Efficacy and cost-effectiveness of guided and unguided internet- and mobile-based indicated transdiagnostic prevention of depression and anxiety (ICa…
2019
Background Depression and anxiety are highly prevalent and often co-occur. Several studies indicate the potential of disorder-specific psychological interventions for the prevention of each of these disorders. To treat comorbidity, transdiagnostic treatment concepts seem to be a promising approach, however, evidence for transdiagnostic concepts of prevention remains inconclusive. Internet- and mobile-based interventions (IMIs) may be an effective means to deliver psychological interventions on a large scale for the prevention of common mental disorders (CMDs) such as depression and anxiety. IMIs have been shown to be effective in treating CMDs, e.g. in reducing symptoms of depression and an…