Search results for "SELE"
showing 10 items of 4721 documents
Development of predictive retention-activity relationship models of tricyclic antidepressants by micellar liquid chromatography.
1999
The distribution of tricyclic antidepressants from plasma to brain, where these drugs exert their main clinical action, and other organs is related to transport events across the cell membranes of the different tissues. It could be expected that all the molecular features that condition the transport processes (mainly hydrophobicity and molar total charge) also control the pharmacokinetic and biochemical behavior. Micellar liquid chromatography (MLC) has been proposed to emulate in vitro the partitioning process in the biomembranes. The use of micellar solutions of Brij35 as mobile phases in reversed-phase liquid chromatography has proven to be valid to predict the biological activities of …
Central Serotonin2C Receptor: From Physiology to Pathology
2006
Since the 1950s, when serotonin (5-HT) was discovered in the mammalian central nervous system (CNS), an enormous amount of experimental evidence has revealed the pivotal role of this biogenic amine in a number of cognitive and behavioural functions. Although 5-HT is synthesized by a small group of neurons within the raphe nuclei of the brain stem, almost all parts of the CNS receive serotonergic projections. Furthermore, the importance of 5-HT modulation and the fine-tuning of its action is underlined by the large number of 5-HT binding sites found in the CNS. Hitherto, up to 15 different 5-HT receptors subtypes have been identified. This review was undertaken to summarize the work that has…
Gaining Competitive Advantage through Standardization and Differentiation of Services
2015
The goal of the paper is to study the question of whether or not differences between cultural groups influence the decision of a consumer wishing to avail himself of a particular service. Therefore we have developed a semiotic extension of the means-end approach as the theoretical basis for elaborating a solution to this problem. The conjoint analysis specifies the results of the meansend analysis.
Design and optimisation of an innovative two-hub-and-spoke network for the Mediterranean short-sea-shipping market
2020
Abstract Short Sea Shipping (SSS) is generally considered as a privileged transport mode in terms of reducing road congestion and related external costs. In the last two decades, SSS has attracted a lot of attention in the European Union, where it is also regarded as a key factor for economic and social cohesion between countries. In this regard, the present study proposes a new network design that aims at improving and increasing freight traffic between the north-western and the south-eastern shores of the Mediterranean Basin. The proposed model, designed for Ro-Ro (Roll-on Roll-off) freight transport, tries to overcome the limits of the existing multi-port-calling services through an inno…
Automating the Parameter Selection in VRP: An Off-line Parameter Tuning Tool Comparison
2014
Vehicle route optimization is an important application of combinatorial optimization. Therefore, a variety of methods has been proposed to solve different challenging vehicle routing problems. An important step in adopting these methods to solve real-life problems is to find appropriate parameters for the routing algorithms. In this chapter, we show how this task can be automated using parameter tuning by presenting a set of comparative experiments on seven state-of-the-art tuning methods. We analyze the suitability of these methods in configuring routing algorithms, and give the first critical comparison of automated parameter tuners in vehicle routing. Our experimental results show that t…
The DrosDel Collection
2004
Abstract We describe a collection of P-element insertions that have considerable utility for generating custom chromosomal aberrations in Drosophila melanogaster. We have mobilized a pair of engineered P elements, p{RS3} and p{RS5}, to collect 3243 lines unambiguously mapped to the Drosophila genome sequence. The collection contains, on average, an element every 35 kb. We demonstrate the utility of the collection for generating custom chromosomal deletions that have their end points mapped, with base-pair resolution, to the genome sequence. The collection was generated in an isogenic strain, thus affording a uniform background for screens where sensitivity to genetic background is high. The…
INTRA-CULTIVAR DIVERSITY IN SOUTHERN ITALY OLIVE CULTIVARS DEPICTED BY MORPHOLOGICAL TRAITS AND SSR MARKERS
2014
In this study, SSR analysis was performed on a large number of putative clones of the main olive cultivars from two Italian regions, Sicily and Calabria, in order to study the genetic relatedness, and to detect any degree of genetic diversity, which can be used to unambiguously identify possible superior clones. These putative clones have been collected and observed in the last ten years, following an extensive investigation carried out in traditional olive growing areas, thanks to the reports of farmers, millers, technician, growers and nurseries. The set of microsatellite (SSR) markers used allowed the detection of the genetic diversity, resulting from somatic mutation, indicating the pre…
Intra-cultivar Diversity in sicilian and calabrian olive (olea europaea L.) Cultivars Depicted by Morphological Traits and SSR Markers
2012
In this study, SSR analysis was performed on a large number of putative clones of the main olive cultivars from two Italian regions, Sicily and Calabria, in order to study the genetic relatedness, and to detect any degree of genetic diversity, which can be used to unambiguously identify possible superior clones. These putative clones have been collected and observed in the last ten years, following an extensive investigation carried out in traditional olive growing areas, thanks to the reports of farmers, millers, technician, growers and nurseries. The set of microsatellite (SSR) markers used allowed the detection of the genetic diversity, resulting from somatic mutation, indicating the pre…