Search results for "SELE"
showing 10 items of 4721 documents
Use of molecular topology in the selection of new cytostatic drugs
2000
Abstract Connectivity indices are the topological descriptors that are able to predict different chemical and biological properties of the organic compounds. Recently, our research group has demonstrated their usefulness in selecting new cytostatic compounds, all of them showing antibacterial activity. In this paper we realize that this ability is considerably increased by using our home-made pharmacological distribution diagrams (PDDs) together with the topological charge indices, so that the efficient selection of new candidates within heterogeneous sets of compounds is possible. This is a straightforward way for the design and/or selection of new active compounds on virtually any type of…
Ibrutinib Abrogates TREM-1 Mediated Neutrophil Activation
2016
Abstract Triggering receptor expressed on myeloid cells 1 (TREM-1) is an activating receptor on neutrophils (PMN) and important in the innate host defence against microbial pathogens. Here we examined the influence of the Bruton tyrosine kinase (BTK) inhibitor ibrutinib on TREM-1 dependent activation of human PMNs. Firstly, ibrutinib specifically inhibited TREM-1 mediated PMN activation of the oxidative burst and CD62L shedding, whereas TLR mediated activation remained unaffected. Correspondingly, ibrutinib suppressed ERK phosphorylation after TREM-1, but not after TLR ligation. To clarify whether this TREM-1 specific effect of ibrutinib was also relevant in vivo, we treated mice with ibrut…
The effect of periodic bottlenecks on the competitive ability of Drosophila pseudoobscura lines.
1993
Competition experiments between several Drosophila pseudoobscura strains that were previously subjected to periodic bottlenecks of different sizes and D. willistoni have been carried out. Contrary to previous results with these two species, where stable coexistence was detected, populations of D. pseudoobscura displaced D. willistoni in a few generations. By using a relative fitness measure, the control lines (that had not gone through bottlenecks) outcompeted D. willistoni faster than bottlenecked lines. One of these, corresponding to the minimum possible bottleneck size of one pair, also shows significantly lower relative fitness than the other strains. These results are discussed in rela…
CCDC 915014: Experimental Crystal Structure Determination
2013
Related Article: Zulema Arcis-Castillo,Lucia Pineiro-Lopez,M. Carmen Munoz,Rafael Ballesteros,Belen Abarca,Jose Antonio Real|2013|CrystEngComm|15|3455|doi:10.1039/C3CE00003F
CCDC 143351: Experimental Crystal Structure Determination
2001
Related Article: O.Blacque, H.Brunner, M.M.Kubicki, F.Leis, D.Lucas, Y.Mugnier, B.Nuber, J.Wachter|2001|Chem.-Eur.J.|7|1342|doi:10.1002/1521-3765(20010316)7:6<1342::AID-CHEM1342>3.0.CO;2-D
CCDC 817953: Experimental Crystal Structure Determination
2012
Related Article: J.Konu, T.Chivers, H.M.Tuononen|2011|Chem.-Eur.J.|17|11844|doi:10.1002/chem.201100891
CCDC 782269: Experimental Crystal Structure Determination
2011
Related Article: M.Bodensteiner, M.Dusek, M.M.Kubicki, M.Pronold, M.Scheer, J.Wachter, M.Zabel|2010|Eur.J.Inorg.Chem.||5298|doi:10.1002/ejic.201000796
CCDC 2096753: Experimental Crystal Structure Determination
2021
Related Article: Juan-Ram��n Jim��nez, Buqing Xu, Hasnaa El Said, Yanling Li, Jurgen von Bardeleben, Lise-Marie Chamoreau, Rodrigue Lescou��zec, Sergiu Shova, Diana Visinescu, Maria-Gabriela Alexandru, Joan Cano, Miguel Julve|2021|Dalton Trans.|50|16353|doi:10.1039/D1DT02441H
On the origin and diversification of Podolian cattle breeds: testing scenarios of European colonization using genome-wide SNP data
2021
AbstractBackgroundDuring the Neolithic expansion, cattle accompanied humans and spread from their domestication centres to colonize the ancient world. In addition, European cattle occasionally intermingled with both indicine cattle and local aurochs resulting in an exclusive pattern of genetic diversity. Among the most ancient European cattle are breeds that belong to the so-called Podolian trunk, the history of which is still not well established. Here, we used genome-wide single nucleotide polymorphism (SNP) data on 806 individuals belonging to 36 breeds to reconstruct the origin and diversification of Podolian cattle and to provide a reliable scenario of the European colonization, throug…
Ensemble feature selection with the simple Bayesian classification
2003
Abstract A popular method for creating an accurate classifier from a set of training data is to build several classifiers, and then to combine their predictions. The ensembles of simple Bayesian classifiers have traditionally not been a focus of research. One way to generate an ensemble of accurate and diverse simple Bayesian classifiers is to use different feature subsets generated with the random subspace method. In this case, the ensemble consists of multiple classifiers constructed by randomly selecting feature subsets, that is, classifiers constructed in randomly chosen subspaces. In this paper, we present an algorithm for building ensembles of simple Bayesian classifiers in random sub…