Search results for "SELE"

Anthropometric measurements and nutritional assessment in autism spectrum disorders: A systematic review

2015

Abstract Adequate nutrient intake is essential for health. Due to food selectivity and restrictive diets, people with autism spectrum disorder (ASD) may have impaired nutritional status, which could affect their growth. We present a systematic review of publications (1970–2013) on anthropometric measurements and nutritional assessment in this population. The limited research published on growth and nutritional status has found contradictory results. Nutritional assessment has indicated limited food variety in the ASD population but has not confirmed significant differences with respect to recommended intakes or controls. In addition to the lack of control groups, studies in this area have s…

Mapping of the human visual cortex using image-guided transcranial magnetic stimulation

2002

We describe a protocol using transcranial magnetic stimulation (TMS) to systematically map the visual sensations induced by focal and non-invasive stimulation of the human occipital cortex. TMS is applied with a figure of eight coil to 28 positions arranged in a 2x2-cm grid over the occipital area. A digitizing tablet connected to a PC computer running customized software, and audio and video recording are used for detailed and accurate data collection and analysis of evoked phosphenes. A frameless image-guided neuronavigational device is used to describe the position of the actual sites of the stimulation coils relative to the cortical surface. Our results show that TMS is able to elicit p…

Dissociable Effects of Reward on P300 and EEG Spectra Under Conditions of High vs. Low Vigilance During a Selective Visual Attention Task

2020

The influence of motivation on selective visual attention in states of high vs. low vigilance is poorly understood. To explore the possible differences in the influence of motivation on behavioral performance and neural activity in high and low vigilance levels, we conducted a prolonged 2 h 20 min flanker task and provided monetary rewards during the 20- to 40- and 100- to 120-min intervals of task performance. Both the behavioral and electrophysiological measures were modulated by prolonged task engagement. Moreover, the effect of reward was different in high vs. low vigilance states. The monetary reward increased accuracy and decreased the reaction time (RT) and number of omitted response…

Rationale and design of the EMBRACE STEMI Study: A phase 2a, randomized, double-blind, placebo-controlled trial to evaluate the safety, tolerability …

2012

Background Although significant efforts have been made to improve ST-segment elevation myocardial infarction (STEMI) outcomes by reducing symptom-onset-to-reperfusion times, strategies to decrease the clinical impact of ischemic reperfusion injury have demonstrated limited success. Bendavia, an intravenously administered mitochondrial targeting peptide, has been shown to reduce myocardial infarct size and attenuate coronary no-reflow in experimental modelswhen given before reperfusion. Design The EMBRACE STEMI study is a phase 2a, randomized, double-blind, placebo-controlled trial enrolling 300 patients with a first-time anterior STEMI and an occluded proximal or mid–left anterior descendin…

Microalbuminuria and endothelial activation in treated and untreated diabetic and non-diabetic hypertensives

2004

Association of selenium exposure with insulin resistance and β-cell function in middle age and older adults

2021

Lovastatin stimulates p75 TNF receptor (TNFR2) expression in primary human endothelial cells

2005

HMG-CoA reductase inhibitors (statins) exert pleiotropic physiological effects. Among others they attenuate cellular responses to genotoxic and inflammatory stress. We investigated the effect of lovastatin on the expression level of TNF receptors (TNFR) in primary human endothelial cells (HUVEC). ELISA, FACS and immunocytochemical analyses show that lovastatin selectively increases the cell surface expression of TNFR2 without affecting the expression level of TNFR1. This effect of lovastatin is independent from inhibition of cell-cycle progression since cells both in G1- and G2-phase showed elevated levels of TNFR2 after lovastatin treatment. To analyze the physiological relevance of lovast…

Group 1 ITI Consensus Report: The influence of implant length and design and medications on clinical and patient-reported outcomes

2018

The following article: Jung, R.E., Al-Nawas, B., Araujo, M., Avila-Ortiz, G., Barter, S., Brodala, N., ... Windisch, P. (2018). Group 1 ITI Consensus Report: The influence of implant length and design and medications on clinical and patient-reported outcomes. Clinical Oral Implants Research, 29(S16), 69-77, can be accessed at https://doi.org/10.1111/clr.13342. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Objectives: The aim of Working Group 1 was to address the influence of different local (implant length, diameter, and design) and systemic (medications) factors on clinical, radiographic, and patient‐re…

Absence of the lactase-persistence-associated allele in early Neolithic Europeans.

2007

Lactase persistence (LP), the dominant Mendelian trait conferring the ability to digest the milk sugar lactose in adults, has risen to high frequency in central and northern Europeans in the last 20,000 years. This trait is likely to have conferred a selective advantage in individuals who consume appreciable amounts of unfermented milk. Some have argued for the “culture-historical hypothesis,” whereby LP alleles were rare until the advent of dairying early in the Neolithic but then rose rapidly in frequency under natural selection. Others favor the “reverse cause hypothesis,” whereby dairying was adopted in populations with preadaptive high LP allele frequencies. Analysis based on the cons…

Descubriendo nuevos antibióticos producidos por bacterias del suelo

2019

El abuso y/o uso inadecuado de antibióticos es actualmente un grave problema en nuestra sociedad que hace que los microorganismos adquieran resistencias frente a estos compuestos antimicrobianos. Estas resistencias son debidas a la presión de selección que ejercemos sobre los microorganismos, lo que dificulta el tratamiento de las enfermedades que causan algunos de ellos. Por lo tanto, se hace necesario la búsqueda de nuevos antibióticos mediante distintas estrategias, siendo una de ellas la relacionada con la participación ciudadana. El objetivo principal del presente proyecto, basado en una estrategia de Aprendizaje-Servicio (ApS), se ha centrado en la realización de una propuesta educati…