Search results for "SEP"
showing 10 items of 2642 documents
Antisense Phosphorothioate Oligonucleotides to the p65 Subunit of NF-κB Abrogate Fulminant Septic Shock Induced byS. typhimuriumin Mice
2001
The aim of this study was to characterize the functional relevance of the transcription factor NF-κB in the pathogenesis of septic shock. BALB/c mice were infected with two wild-type (WT 1, WT 2) strains of S. typhimurium that induce NF-κB or an escape variant that lacks this ability (P21) at a dose of 1 × 109/animal, respectively. Furthermore, wild-type infected mice were treated with antisense oligonucleotides directed against NF-κB 24 h before and 3 or 6 h after infection, while mismatched oligonucleotides were used as controls. Subsequently, the clinical course, histological and immunological alterations were monitored. Infection with WT 1 and WT 2 strains led to lethal septic shock wit…
A no-carrier-added 72Se/72As isotope generator
2001
Siinznrary A no-carrier-added 72Se/72As generator has been developed for the isolation of 72As, relevant for eventual application in the syntheses of 72As-labelled radiophamaceuticals. Avoiding the addition of Se carrier and using a thennochromatographic destillation process, no-carrier-added 72As is nearly quantitatively released within 10 min. 72Se remains almost quantitatively (> 99.7%) in solution when a temperature of the separation process of 100°C is applied. Introdiiction Arsenic-72 is a positron emitting isotope with properties which are promising for eventual application in 72As-labelled radiopharmaceuticals. It has n positron emission rate of 88% and positron energies of EP+,,,,~…
Sodium channels enable fast electrical signaling and regulate phagocytosis in the retinal pigment epithelium
2019
Background Voltage-gated sodium (Nav) channels have traditionally been considered a trademark of excitable cells. However, recent studies have shown the presence of Nav channels in several non-excitable cells, such as astrocytes and macrophages, demonstrating that the roles of these channels are more diverse than was previously thought. Despite the earlier discoveries, the presence of Nav channel-mediated currents in the cells of retinal pigment epithelium (RPE) has been dismissed as a cell culture artifact. We challenge this notion by investigating the presence and possible role of Nav channels in RPE both ex vivo and in vitro. Results Our work demonstrates that several subtypes of Nav cha…
Assessing divergence time of Spirulida and Sepiida (Cephalopoda) based on hemocyanin sequences
2011
Abstract The phylogenetic position of the mesopelagic decabrachian cephalopod Spirula is still a matter of debate. Since hemocyanin has successfully been used to calibrate a molecular clock for many molluscan species, a molecular clock was calculated based on this gene with special attention to the cephalopod genera Spirula and Sepia. The obtained partial sequence comprising ca., one third (3567 bp) of the complete gene is similar to that of Sepia officinalis. The molecular clock was calibrated using the splits of Gastropoda–Cephalopoda (ca. 550 ± 50 mya) and Heterobranchia–Vetigastropoda (ca. 380 ± 10 mya). The resulting hemocyanin-based molecular clock is stable, and the estimated diverge…
Liikunnallisuus ja hyvä kunto ehkäisevät tyypin 2 diabetesta ja valtimotautien riskitekijöitä lapsesta lähtien
2021
Lasten ylipaino on saavuttanut epidemian mittasuhteet maailmanlaajuisesti. Vaikka viime vuosina tilanne on hiukan parantunut, ylipaino on edelleen yksi merkittävimmistä kansanterveydellisistä ongelmista. Riskitekijöiden kasautumisen ehkäisy ja hoito tulisi aloittaa mahdollisimman varhain: mielellään jo sikiöaikana tai viimeistään varhaislapsuudessa. nonPeerReviewed
Fouling mechanism elucidation in membrane bioreactors by bespoke physical cleaning
2018
Abstract Cake layer deposition on a membrane surface can determine both external and internal membrane fouling through negatively affecting the total filtration resistance while exerting a positive effect as a pre-filter. Membranes are usually subjected to a periodic cake layer removal through routine physical cleaning, specifically permeate backwashing of hollow fiber membranes, or enhanced cleaning through, for example, chemically-enhanced backwashing. Physical cake layer removal is crucial for sustaining permeability, yet the effect of different physical cleaning modes remains poorly evaluated. The present work attempts to analyze physical cake layer removal through the application of sp…
Polycaprolactone-based scaffold for oil-selective sorption and improvement of bacteria activity for bioremediation of polluted water: Porous PCL syst…
2017
A novel floatable and biodegradable sponge for the selective absorption of oil from water and potentially useful as cell carrier for bioremediation treatments was prepared in polycaprolactone (PCL). The eco-friendly process for fabricating the PCL sponge does not involve either synthetic routes or organic solvents, thus minimizing environmental hazard. In particular, the 3D porous materials have been prepared by mixing in the melt the polymer matrix with two water-soluble porogen agents (NaCl and PEG) and thereafter leaching the obtained PCL/NaCl/PEG composites in water. The PCL sponges here proposed are capable to remove different types of oily pollutants (up to 500 wt%), and were successf…
Experimental study of isomeric intruder 12+ states in At197,203
2017
A newly observed isomeric intruder ${\textonehalf{}}^{+}$ state $[{T}_{\textonehalf{}}=3.5(6)\phantom{\rule{0.16em}{0ex}}\mathrm{ms}]$ is identified in $^{203}\mathrm{At}$ using a gas-filled recoil separator and fusion-evaporation reactions. The isomer is depopulated through a cascade of $E3$ and mixed $M1/E2$ transitions to the ${9/2}^{\ensuremath{-}}$ ground state, and it is suggested to originate from the $\ensuremath{\pi}{({s}_{\textonehalf{}})}^{\ensuremath{-}1}$ configuration. In addition, the structures above the ${\textonehalf{}}^{+}$ state in $^{203}\mathrm{At}$ and $^{197}\mathrm{At}$ are studied using in-beam $\ensuremath{\gamma}$-ray spectroscopy, recoil-decay tagging, and recoi…
Dynamical entanglement-transfer for quantum information networks
2004
A key element in the architecture of a quantum information processing network is a reliable physical interface between fields and qubits. We study a process of entanglement transfer engineering, where two remote qubits respectively interact with entangled two-mode continuous variable (CV) field. We quantify the entanglement induced in the qubit state at the expenses of the loss of entanglement in the CV system. We discuss the range of mixed entangled states which can be obtained with this set-up. Furthermore, we suggest a protocol to determine the residual entangling power of the light fields, inferring, thus, the entanglement left in the field modes which, after the interaction, are no lon…
Excited states in the three-body system
1972
Three-body excited states are calculated in a local potential model by means of the quasi-particle method. The improvement over the approach in which the local potential is approximated by a separable one is demonstrated.