Search results for "SEP"
showing 10 items of 2642 documents
Protection of islets in culture by delivery of oxygen binding neuroglobin via protein transduction.
2005
Islet transplantation has become an accepted method to treat type 1 diabetes. To succeed and achieve normal levels of glucose in transplant recipients, the quality of the transplanted islets is of the utmost importance. Lack of oxygen during organ procurement, islet isolation, and subsequent culture triggers apoptosis or necrosis and loss of islet function, causing the yield and quality to diminish. A promising candidate for cytoprotection against oxygen deprivation is neuroglobin (Ngb). Ngb is a recently described member of globin family and is expressed in neurons, retina, and pancreatic islets. To overexpress this protein in the islets and study its ability to protect them, we utilized p…
Idiosyncratic responses to simulated herbivory by root fungal symbionts in a subarctic meadow
2021
Plant-associated fungi have elementary roles in ecosystem productivity. There is little information on the interactions between arbuscular mycorrhizal (AM) fungal symbiosis, fine endophytic (FE) and dark septate endophytic (DSE) fungi, and their host plants in cold climate systems. In particular, the environmental filters potentially driving the relative abundance of these root symbionts remain unknown. We investigated the interlinkage of plant and belowground fungal responses to simulated herbivory (clipping, fertilization, and trampling) in a subarctic meadow system. AM and FE frequency in the two target plant roots, Potentilla crantzii and Saussurea alpina, was unaffected by simulated he…
Identificación de los mecanismos epigenéticos relacionados con los fenómenos de inmunosupresión en sepsis y su uso como biomarcadores de pronóstico
2023
La sepsis es un síndrome complejo que provoca una respuesta inmunitaria exacerbada como resultado a una infección, lo que puede causar disfunción orgánica y, en última instancia, la muerte. La sepsis puede avanzar a shock séptico (SS), caracterizado por una disfunción orgánica aguda que puede provocar una insuficiencia circulatoria y metabólica grave, aumentando el riesgo de mortalidad. Los pacientes con sepsis o SS ingresados durante al menos 7 días en la Unidad de Cuidados Intensivos (UCI) que presentan disfunción orgánica y necesidad de ventilación mecánica se clasifican como enfermos críticos crónicos (ECC), los cuales, si están ingresados al menos 14 días y cumplen una serie de caracte…
Reflections of Hope and Anxiety in Audience Responses to Three Environmental Films
2023
This article discusses the results of a reception study of three environmental films with a focus on emotional reactions and the films’ influence on the respondents’ environmental awareness. The short experimental film Valtakunnat/Realms (Finland, 2018) envisions post-human life, and the potential destruction that the planet is being driven towards. To Teach a Bird to Fly (Finland, 2020), a short documentary fiction film about a woman raising critically endangered birds, imagines a future where the effects of climate change have been reversed. The documentary film The Biggest Little Farm (USA, 2018) follows a couple who buy a barren farm with the aim of restoring its biodiversity. Through t…
Uso de las histonas circulantes y sus modificaciones post-traduccionales como biomarcadores en sepsis y shock séptico
2022
La sepsis es una afección potencialmente mortal causada por una respuesta anormal del huésped a una infección, produciendo respuestas fisiológicas alteradas que dañan los propios tejidos del paciente y pueden provocar disfunción orgánica e incluso la muerte. Asimismo, algunos pacientes sépticos progresan a shock séptico, caracterizado por alteraciones circulatorias, celulares y metabólicas sustanciales que aumentan el riesgo de mortalidad. A pesar de que la sepsis se caracteriza por un mal funcionamiento del sistema inmunológico, lo que a su vez conduce a una respuesta inmune alterada e inmunosupresión, la alta complejidad de la fisiopatología de la sepsis requiere una mayor investigación p…
Le aree funerarie cristiane
2017
This paper shows the data edited and acquired in June and October 2010 by surveys in Sabratha made by researchers at the University of Palermo, in collaboration whit the CNR ITABC for the PRIN 2008 Project. It consists of a preliminary study for an archaeological gis of Sabratha to promote analysis regarding the riuse of space in the Regiones III-V of Sabratha, after the destruction attribuited to the earthquake on 21th July 365. In particular, the paper presents the results of the first study concerning the catacomb in the eastern suburbs, the sub-divo funerary areas between the churches 3 and 4 and the so-called Baths ofOceanus, the necropolis sub-divo North-East of the Theater and, final…
La estatua marmórea del duque de Lerma en el castillo de Dénia, obra de Giuseppe Carlone
2018
On the 28th of August of 1612, Juan Vivas de Canamas, the ambassador of king Philip III in Genoa, commissioned the Genoese sculptor Giuseppe Carlone to carve a large statue made of Polveracio white marble representing, according to the drawing attached to the contract, the figure of a knight. The portrait depicts none other than the Duke of Lerma, whose marble effigy was intended to preside in his castle and palace of the Valencian city of Denia and was installed there at the end of 1613. In this sense, the work is historically framed in the process of renovation of the castle that Lerma began at the end of the 16th century and that included the incorporation of this exclusive artistic comm…
Small molecule modulators of amine oxidation, nuclear receptor signaling and glucuronidation : 3-phenylcoumarin as a scaffold of interest
2018
The costs of the drug development process are moderated as computer-aided drug design methods are able to expedite the steps required for lead identification. In fact, computational tools are nowadays virtually indispensable from target identification and validation to preclinical tests due to exponential growth of available information regarding both potential targets and small molecules. One such small molecule with growing number of variations is coumarin. Coumarin scaffold and its various derivatives continue to interest researchers for their vast application potential. Since naturally occurring coumarins are known for example for their antioxidant and anti-inflammatory properties, thos…