Search results for "SFE"

Abnormalities in alpha-dystroglycan expression in MDC1C and LGMD2I muscular dystrophies

2004

We recently identified mutations in the fukutin related protein (FKRP) gene in patients with congenital muscular dystrophy type 1C (MDC1C) and limb girdle muscular dystrophy type 2I (LGMD2I). The sarcolemma of these patients typically displays an immunocytochemical reduction of alpha-dystroglycan. In this report we extend these observations and report a clear correlation between the residual expression of alpha-dystroglycan and the phenotype. Three broad categories were identified. Patients at the severe end of the clinical spectrum (MDC1C) were compound heterozygote between a null allele and a missense mutation or carried two missense mutations and displayed a profound depletion of alpha-d…

Influence of the Screw Positioning on the Stability of Locking Plate for Proximal Tibial Fractures: A Numerical Approach

2020

Tibial fractures are common injuries in people. The proper treatment of these fractures is important in order to recover complete mobility. The aim of this work was to investigate if screw positioning in plates for proximal tibial fractures can affect the stability of the system, and if it can consequently influence the patient healing time. In fact, a more stable construct could allow the reduction of the non-weight-bearing period and consequently speed up the healing process. For that purpose, virtual models of fractured bone/plate assemblies were created, and numerical simulations were performed to evaluate the reaction forces and the maximum value of the contact pressure at the screw/bo…

Enhanced prolylhydroxylase activity in the posterior annulus fibrosus of canine intervertebral discs following long-term running exercise

2010

The effect of long-term excercise on the intervertebral disc collagen concentration (hydroxyproline), collagen-synthesizing enzymes (prolyl-4-hydroxylase, PH, and galactosyl-hydroxylysyl glucosyltransferase, GGT) and hydroxypyridinium crosslinks was studied in ten female beagle dogs. The dogs were run on a treadmill for 1 year starting at the age of 15 weeks. The daily running distance was gradually increased to 40km, which distance the dogs ran for the final 15 weeks. Ten untrained dogs from the same breeding colony served as controls. The nucleus pulposus and anterior and posterior halves of the annulus fibrosus of C2-3, T10-12, L4-5 disc segments were analysed. Crosslinks were measured f…

Meaning of countertransference in a music therapy student's clinical studies - towards a professional perspective

2013

The concept of countertransference refers to the therapist's reactions to the client's inner world in therapy situation. Countertransference within therapy relationships can alternate from the therapist's obstructive reactions to positive experiences that may even guide the therapist towards purposeful interventions. In this research I study my own countertransference experience and my learning process of the meaning of countertransference. The methodology of the research is hermeneutic phenomenology and its structure follows the principles of the hermeneutic circle and of Gadamerian hermeneutic analysis. The data is composed of my self-reflections. I examine the self-reflections in the lig…

Vastatunteiden dynamiikka musiikkiterapiassa

2005

Immune-mediated rippling muscle disease with myasthenia gravis: a report of seven patients with long-term follow-up in two.

2009

We report seven patients with immune-mediated rippling muscle disease (iRMD) and AChR-antibody positive myasthenia gravis (MG) without germline caveolin-3 gene mutations. We describe the follow-up of two patients and the clinical features of five new patients (1 female, 4 male, aged 32 to 69 years). These presented with significant generalized, exercise-induced and electrically-silent muscle rippling with myalgia, combined with generalized MG. In two of the seven patients, MG appeared before iRMD. Mediastinal imaging excluded thymic alterations in all, although two had other coincident tumours. Myalgia and rippling were aggravated by acetylcholinesterase-inhibitor treatment. Generalized MG …

Revista de educación

2013

Un objetivo esencial de la educación formal es fomentar la transferencia de los aprendizajes, definida como la aplicación de un conocimiento aprendido en un contexto particular a una situación distinta. Sin embargo, con frecuencia los estudiantes no alcanzan a aplicar lo aprendido en el aula a situaciones de la vida cotidiana. Aunque existe un amplio consenso sobre la relevancia de la transferenciacomo refleja su peso en las evaluaciones PISA, nuestro conocimiento científico sobre este fenómeno es aún escaso. De hecho, gran parte de las investigaciones empíricas que comparan la efectividad de diversos métodos instructivos evalúan el aprendizaje de los alumnos con tareas que requieren que es…

Construcción de analogías y éxito en la resolución de problemas de matemáticas y ciencias: Un estudio con alumnado de Secundaria

2013

Resumen tomado de la publicación Documento bilingüe en español y en inglés Se desarrolla un estudio empírico con estudiantes de Secundaria para analizar la asociación entre detectar las analogías superficiales y estructurales entre problemas, y el éxito algebraico medido a través de las ecuaciones seleccionadas para resolverlos. Se consideraron distintas relaciones superficiales y estructurales entre un problema fuente y cuatro problemas diana. Se consideraron problemas con temáticas de alta (vida diaria) o baja familiaridad (ciencia). Se pidió a los estudiantes comparar el problema fuente con cada problema diana para establecer las similitudes y diferencias entre ellos. Los resultados most…

Tradurre lo Yoga

2022

Il presente articolo descrive in maniera dettagliata il lavoro svolto e le tecniche traduttive utilizzate per tradurre dall’inglese all’italiano il testo Contemporary Yoga Education: Transforming the Body, Mind and Soul. In particolare, è stata applicata la teoria della ‘naturalizzazione’, in cui il processo traduttivo non viene visto come un mero passaggio dalla lingua di partenza alla lingua di arrivo, ma come un meccanismo più ampio in cui la lingua di partenza su- bisce una trasformazione per adattarsi alla lingua di arrivo e la lingua di arrivo, a sua volta, va incontro a cambiamenti per accogliere e incorporare, attraverso le proprie risorse, quelle cioè sue naturali, la lingua di par…

Generalized Noise Study of Solid-State Nanopores at Low Frequencies.

2017

Nanopore technology has been extensively investigated for analysis of biomolecules, and a success story in this field concerns DNA sequencing using a nanopore chip featuring an array of hundreds of biological nanopores (BioNs). Solid-state nanopores (SSNs) have been explored to attain longer lifetime and higher integration density than what BioNs can offer, but SSNs are generally considered to generate higher noise whose origin remains to be confirmed. Here, we systematically study low-frequency (including thermal and flicker) noise characteristics of SSNs measuring 7 to 200 nm in diameter drilled through a 20-nm-thick SiNx membrane by focused ion milling. Both bulk and surface ionic curren…