Search results for "SHM"

Visceral leishmaniasis in a patient with Down syndrome

2006

Visceral leishmaniasis during pegylated interferon therapy for chronic hepatitis C: first report.

2005

See: Puoti et al. Use of pegylated interferons is associated with an increased incidence of infections during combination treatment of chronic hepatitis C: a side effect of pegylation? Antiviral Therapy 2004; 9:627–630.

Harmonic reduction in CHB 13-level inverters by PAM fundamental-frequency strategy

2019

In this paper cascaded H-bridges (CHB) 13-level inverters are considered and a particular pulse amplitude modulation (PAM) strategy is introduced to mitigate or eliminate many harmonic components on the output voltage, in order to obtain low Total Harmonic Distortion (THD) factor. This procedure defines different dc voltage sources and sets of six switching angles, depending on an integer parameter $q$ belonging to the close interval $I=[11, 15]$ . The obtained THD doesn't depend on modulation index $m$ . The control of $m$ is made by changing the dc voltage sources that depend linearly on m, while the switching angles remain constant. An investigation about the role of the $q$ parameter on…

Pool punishment in public goods games: How do sanctioners’ incentives affect us?

2021

Abstract Centralized sanctioning in social dilemmas has been shown to increase efficiency with respect to standard decentralized peer punishment. In this context, we explore the impact of sanctioners’ motivations through their payoff scheme, not only on their actions but also on the actions of the monitored individuals. To do so, we compare the implementation of two different payoff schemes for the monitor in a centralized sanctioning framework: (i) a fixed payoff scheme and (ii) a variable payoff scheme contingent on the level of cooperation achieved. We find that providing the sanctioner with a contingent payoff has a negative impact on contributions. This occurs although sanctioners impl…

Effects of sesame seed meal and bambaranut meal on growth, feed utilization and body composition of juvenile African catfish Clarias gariepinus

2014

Plant proteins are plausible fishmeal substitutes but are deficient in some essential amino acids (EAA) like lysine and methionine. Combination of different plant proteins with complimentary EAA could be a useful alternative. Bambaranut (Voandzeia subterranea) contains high amount of lysine while methionine is in sesame seed (Sesamum indicum). This experiment tested effects of combining sesame seed meal (SSM) and bambaranut meal (BNM) on juvenile African catfish Clarias gariepinus. Inclusion levels (%) of SSM:BNM in four novel diets were feed 1 (F1) 0:35, feed 2 (F2) 11.7:23.3, feed 3 (F3) 23.3:11.7, feed 4 (F4) 35:0. Catfish (initial weight ± SD 11.7 ± 0.56 g) were stocked in four replicat…

TLR4 abrogates the Th1 immune response through IRF1 and IFN-β to prevent immunopathology during L. infantum infection

2020

A striking feature of human visceral leishmaniasis (VL) is chronic inflammation in the spleen and liver, and VL patients present increased production levels of multiple inflammatory mediators, which contribute to tissue damage and disease severity. Here, we combined an experimental model with the transcriptional profile of human VL to demonstrate that the TLR4-IFN-β pathway regulates the chronic inflammatory process and is associated with the asymptomatic form of the disease. Tlr4-deficient mice harbored fewer parasites in their spleen and liver than wild-type mice. TLR4 deficiency enhanced the Th1 immune response against the parasite, which was correlated with an increased activation of de…

The Clinician's Duty to Warn or Protect: In the United States, England, Canada, New Zealand, France and Spain

2008

Peasants and the Political Culture in Norway (c. 1400–1700)

2016

This chapter looks at the major confrontations between the state and peasants in Norway during the period 1400–1700. These have variously been described as rebellions, riots and insurrections. Indeed, one could argue that none of these were full-scale revolts as such, if by that we mean a massive threat to the regime and social order. The peasants and their leaders would never declare that they were seeking to abolish the regime or attack the king nor that they intended to implement a new social or political order. In most cases, they would address oral or written protests or sabotage the collection of new taxes or other burdens that the state had imposed. Their protests would primarily be …

Priming of Leishmania-Reactive CD8+ T cells In Vivo Does Not Require LMP7-Containing Immunoproteasomes

2012

Vaccination with TAT-Antigen Fusion Protein Induces Protective, CD8+ T Cell-Mediated Immunity Against Leishmania Major

2010

In murine leishmaniasis, healing is mediated by IFN-γ-producing CD4 + and CD8 + T cells. Thus, an efficacious vaccine should induce Th1 and Tc1 cells. Dendritic cells (DCs) pulsed with exogenous proteins primarily induce strong CD4-dependent immunity; induction of CD8 responses has proven to be difficult. We evaluated the immunogenicity of fusion proteins comprising the protein transduction domain of HIV-1 TAT and the Leishmania antigen LACK ( Leishmania homolog of receptors for activated C kinase), as TAT-fusion proteins facilitate major histocompatibility complex class I-dependent antigen presentation. In vitro , TAT–LACK-pulsed DCs induced stronger proliferation of Leishmania -specific C…