Search results for "SHM"

In vitro and in vivo antileishmanial and trypanocidal studies of new N-benzene- and N-naphthalenesulfonamide derivatives.

2013

We report in vivo and in vitro antileishmanial and trypanocidal activities of a new series of N-substituted benzene and naphthalenesulfonamides 1-15. Compounds 1-15 were screened in vitro against Leishmania infantum , Leishmania braziliensis , Leishmania guyanensis , Leishmania amazonensis , and Trypanosoma cruzi . Sulfonamides 6e, 10b, and 10d displayed remarkable activity and selectivity toward T. cruzi epimastigotes and amastigotes. 6e showed significant trypanocidal activity on parasitemia in a murine model of acute Chagas disease. Moreover, 6e, 8c, 9c, 12c, and 14d displayed interesting IC50 values against Leishmania spp promastigotes as well as L. amazonensis and L. infantum amastigot…

Localized leishmaniasis of the oral mucosa. A report of three cases

2007

El término leishmaniasis comprende un grupo de enfermedades causadas por diferentes especies de un protozoo llamado Leishmania. La leishmaniasis se produce en todo el mundo, considerándose endémica en 88 países. Existen tres formas clínicas principales de leishmaniasis: leishmaniasis visceral, leishmaniasis cutánea y leishmaniasis mucocutánea. La afectación de la mucosa, de manera exclusiva, por la Leishmania es muy rara. Presentamos una serie de tres casos de leishmaniasis mucosa localizados en la cavidad oral. El hecho de que todos los casos se produjeran en España, área endémica de L infantum, nos hace presuponer que éste fue el agente causal. La única manifestación de enfermedad de leis…

Punishment as Defiance: Deterrence and Perverse Effects in the Case of Expressive Crime

2013

Expressive crime contrasts with instrumental crime in that delinquents do not seek material benefits. Law-breakers are motivated by the desire to “make a statement”, possibly against majority attitudes in the society. Fighting expressive crime is complicated by this fact in that increasing intervention may have counter-effects. In this paper, I present a model of expressive crime. Delinquents are motivated to perform the illegal action because it transmits a signal. If the punishment associated with the crime affects the value of this signal positively, an increase in punishment may serve as defiance, and not as deterrence. Accordingly, the number of law violations may increase if those def…

The whip and the Bible : punishment versus internalization

2021

First published online: 27 August 2021 A variety of experimental and empirical research indicate that prosocial behavior is important for economic success. There are two sources of prosocial behavior: incentives and preferences. The latter, the willingness of individuals to “do their bit” for the group, we refer to as internalization, because we view it as something that a group can influence by appropriate investment. This implies that there is a trade-off between using incentives and internalization to encourage prosocial behavior. By examining this trade-off we shed light on the connection between social norms observed inside the laboratory and those observed outside in the field. For ex…

Reward and punishment: investigating cortico-bulbar excitability to disclose the value of goods

2013

A continuing challenge for neuroscientists is to develop new conceptual tools and methodologies for understanding, predicting and modelling the influences of rewarding/punishing outcomes on human behaviour and decision making. Reinforcement shapes behaviours from the most primitive (fight/flight, ingest/regurgitate, approach/avoid) to complex (buy/sell). Understanding the neural processes underlying reinforcement is critical for understanding economic and social decision-making. Moreover, comprehension of deranged processing and responses to reinforcing stimuli is crucial across a range of psychology fields and society as a whole, including psychiatric and neurological illness, eating disor…

Leishmaniasis in travelers: A literature review.

2014

Leishmaniasis is a vector-borne protozoan infection whose clinical spectrum ranges from asymptomatic infection to fatal visceral leishmaniasis. Over the last decades, an increase in imported leishmaniasis cases in developed, non-endemic countries, have been pointed-out from a review of the international literature. Among the possible causes are increasing international tourism, influx of immigrants from endemic regions and military operations. The main area for the acquisition of cutaneous leishmaniasis, especially for adventure travelers on long-term trips in highly-endemic forested areas, is represented from South America, whereas popular Mediterranean destinations are emerging as the mai…

Bush y la extrema derecha

2003

Mediterranean visceral leishmaniasis in immunocompetent children. Report of two cases relapsed after specific therapy

2004

Visceral leishmaniasis (VL) is endemic in areas bordering the Mediterranean Sea (Spain, Italy, France, Greece, Morocco, Tunisia) where it is caused by Leishmania infantum and is transmitted by the bite of a hematophagous sandfly belonging to Phlebotomus spp.; the dog constitutes the main reservoir of infection. Two cases of VL in immunocompetent children are described. Both patients lived in endemic areas for leishmaniasis (Sicily) and at admission were febrile, pale and had splenomegaly. In both patients anti-leishmania antibodies were present and a definitive diagnosis was confirmed by demonstration of leishmania parasites by microscopy or polymerase chain reaction (PCR) in the bone marro…

Disasters in the Society of Fear

2019

From immemorial times, Aborigines and ancient cultures were frightened of disasters because these events were seen as divine reprisals or punishment for their sins (as the Noah’s Ark myth shows). Although modern science introduced instrumental thinking to understand disasters, improving the quality of life, it is equally true that capitalism obscured the diagnosis of scientists to protect the system. Blind to see the real problems of earth, today, capitalism offers distorted answers to the problem of climate change, migration and refugee crises, and even to the economic downturn. Based on the tactics of blaming Others, the elite allude to poverty as the precondition toward humanitarian disa…

Does grassland cover limit the replenishment of weed seed banks during seed rain?

2012

International audience