Search results for "SHM"
showing 10 items of 400 documents
IL-1 signalling is dispensable for protective immunity in Leishmania-resistant mice
2010
Leishmaniasis is a parasitic disease affecting ∼12 million people. Control of infection (e.g. in C57BL/6 mice) results from IL-12-dependent production of IFNγ by Th1/Tc1 cells. In contrast, BALB/c mice succumb to infection because of preferential Th2-type cytokine induction. Infected dendritic cells (DC) represent important sources of IL-12. Genetically determined differences in DC IL-1α/β production contribute to disease outcome. Whereas the course of disease was not dramatically altered in IL-1RI(-/-) mice, local administration of IL-1α to infected C57BL/6 mice improved disease outcome. To definitively elucidate the involvement of IL-1 in immunity against leishmaniasis, we now utilized IL…
Immune Modulating Effects of NKT Cells in a Physiologically Low Dose Leishmania major Infection Model after αGalCer Analog PBS57 Stimulation
2014
Leishmaniasis is a parasitic infection affecting ∼12 million people worldwide, mostly in developing countries. Treatment options are limited and no effective vaccines exist to date. Natural Killer T (NKT) cells are a conserved innate-like lymphocyte population with immunomodulating effects in various settings. A number of reports state a role of NKT cells in different models of Leishmania infection. Here, we investigated the effect of NKT cells in a physiologically relevant, intradermal low dose infection model. After inoculation of 103 infectious-stage L. major, comparable numbers of skin-immigrating NKT cells in both susceptible BALB/c mice and resistant C57BL/6 mice were noted. Compared …
Replacement of fishmeal with corn gluten meal in feeds for juvenile rainbow trout (Oncorhynchus mykiss) does not affect oxygen consumption during for…
2017
We compared oxygen consumption (MO2, mg/kg/h) of c. 80 g rainbow trout (Oncorhynchus mykiss) in an intermittent-flow swim respirometer at 15 °C. Before the tests the fish were grown in flow through tanks (15 °C) with either fishmeal (FM) or corn gluten meal (CGM) based diets (c. 52% protein) for a period of 3–4.5 months. Ten individuals from both treatment groups were fasted for 48 h before the swim test, which consisted of 18 loops of 210 s over three different periods: acclimation period (6 loops at 0.5 body lengths per s, BL/s), exercise period (8 loops at increased speed from 1 to 2.5 BL/s with recovery loops at 0.5 BL/s), and a recovery period (four loops at 0.5 BL/s). We did not obser…
COX-2 expression in chondrosarcoma: A role for celecoxib treatment?
2010
Chondrosarcomas are resistant to conventional chemo- and radiotherapy. A subset of chondrosarcomas arises secondarily in the benign tumour syndromes enchondromatosis (EC) and multiple osteochondromas (MO), and prevention of tumour development would greatly improve prognosis. We therefore investigated the effect of selective COX-2 inhibition on chondrosarcoma growth. COX-2 expression was studied in central- and peripheral cartilaginous tumours. The effect of COX-2 inhibition was assessed in four high-grade chondrosarcoma cell lines using celecoxib and NS-398 treatment. COX-2 activity (prostaglandin E-2 (PGE(2)) ELISA) and cell viability were measured. The (prophylactic) effect of celecoxib o…
Party autonomy regarding jurisdiction under the property regimes regulations
2021
The main accomplishment of the Property Regimes Regulations lies in their bringing more coherence into the cross-border family law adjudication. In the field of international jurisdiction, they strive to align the competence in couples? patrimony disputes to that in succession and in separation proceedings, or else to align the competence of the courts to the applicable law. These tendencies are clearly visible in the Regulations? provisions on choice of court agreements. Namely, the Regulations allow for such agreements, but severely limit parties? choice and the possible effects of these clauses. When succession or separation proceedings are pending, it is often only possible to institute…
Knowledge, beliefs and attitudes of Italian female undergraduate students towards HIV infection and risky sexual behaviour. Do female medical student…
2012
<p><strong>Background</strong>: The main purpose of this study was to identify and describe knowledge, beliefs and attitudes towards HIV infection and risky sexual behaviour in female medical freshmen in order to evaluate the possibility of female medical student-based peer education.</p><p><strong>Methods</strong>: Researchers surveyed 560 freshmen: 280 medical students and 280 non medical students at two Italian Universities, collecting the data through anonymous, self administered questionnaires. Data were codified and statistical analysis was computed using Statistica and Openstat 4 software.</p><p><strong>Results</strong>…
BEM analysis of a piezoelectric structural health monitoring system for delamination detection
2013
In the present work a piezoelectric based structural health monitoring (SHM) system is analyzed with the aim of assessing the ability of the piezoelectric patch to detect both edge and embedded delaminations proper of flange-skin composite laminated structures. he boundary element model is developed for piezoelectric solids and is implemented by taking advantage of the multidomain technique to model laminated and cracked configurations. A non-linear spring model interface is then implemented in conjunction with an iterative procedure allowing for the simulation of the finite stiffness of the bonding layers as well as of the non-penetration condition of the delamination surfaces. he dynamic …
Analysis of FBG reflection spectra under uniform and non-uniform transverse loads
2019
Loads applied transversely on the external surface of waveguides change their circular cross-sectional geometry generating birefringence. Due to this effect the reflected spectrum of a Fibre Bragg grating (FBG) undergoes a splitting of the single peak of the Bragg wavelength. In this work, we employed the Transfer Matrix Method (TMM) for x- and y-polarized wave-modes to model the uniform FBG reflection spectra for uniform and non-uniform transverse loads. We also performed experimental measurements for two different transverse load scenarios. The load profiles chosen for these experiments were applied on the FBG sensor through a block of steel and a roll bearing pin. Then, the modelled and …
La gestión de expedientes juveniles de reforma (I): un análisis de su tramitación en la fiscalía provincial de valencia (2011)
2023
Se analizan la tramitación procesal de los expedientes penales incoados a menores de edad en la provincia de Valencia durante el año 2011, estudiando la exploración del menor y la derivación –o no– a mediación. Se deja para una segunda parte el análisis de los supuestos en que se realiza escrito de alegaciones, se sustancia vista y en su caso se impone medida. The procedural processing of criminal files initiated against minors in the province of Valencia during the year 2011 is analyzed, studying the exploration of the minor and the referral –or not– to mediation. The analysis of the cases in which a statement of allegations is made, the hearing is substantiated and, where appropriate, a m…
Article 4 of the Charter of Fundamental Rights of the European Union on the prohibition of torture and inhuman or degrading treatment or punishment
2022
In this publication, I comment you on article 4 of the Charter of Fundamental Rights of the European Union on the prohibition of torture and inhuman or degrading treatment or punishment