Search results for "SID"
showing 10 items of 6756 documents
Adaptation to stressful environments : invasion success of the Colorado potato beetle (Leptinotarsa decemlineata)
2018
Biological invasions, specifically human-induced dispersals, are one of the major threats to our biodiversity and are predicted to increase. Invasive pests provide an opportunity to study whether adaptation to human-induced environments could promote invasions to other human-induced environments. One major anthropogenic selection pressure is created by pesticides, and pests can be exposed to various pesticides in their native, as well as introduced, ranges. I investigated whether exposure to anthropogenic selection (i.e. insecticides and herbicides) and exposure to multiple anthropogenic stressors selects for higher stress tolerance. I also tested whether parental prolonged diapause or inse…
La inscripción de la ciudadanía en la cuba neocolonial (1902-1919) : Sucinta referencia histórico-jurídica
2021
This historical-legal account brieflycovering 17 years of civil registration activity carried out during the neocolonial period by Municipal Judges and Secretaries, specifically that related to registration of Cuban citizens)becomes considerably relevant to understand and to godeeper into the origins of this complex process, as well asto achieve a re-encounter with the history of those who passed through those times, currently a hidden history in the shadows of Civil Registration offices, but still alive and thus allowing us to find all the beauty that there was in it.
Overexpression of SAMDC1 gene in Arabidopsis thaliana increases expression of defense-related genes as well as resistance to Pseudomonas syringae and…
2014
It has been previously described that elevation of endogenous spermine levels in Arabidopsis could be achieved by transgenic overexpression of S-Adenosylmethionine decarboxylase (SAMDC) or Spermine synthase (SPMS). In both cases, spermine accumulation had an impact on the plant transcriptome, with up-regulation of a set of genes enriched in functional categories involved in defense-related processes against both biotic and abiotic stresses. In this work, the response of SAMDC1-overexpressing plants against bacterial and oomycete pathogens has been tested. The expression of several pathogen defense-related genes was induced in these plants as well as in wild type plants exposed to an exogeno…
DESIGN OF SF3B1 SUBUNIT MODULATORS OF THE SF3B SPLICEOSOME COMPLEX
2022
The subject of this dissertation is the search for new therapeutic strategies for pancreatic cancer and aims to implement a Drug Discovery process for the rational design and synthesis of molecules active in the modulation of pathways related to the regulation of pre-mRNA splicing process. This research project is the result of a joint PhD between the University of Palermo, Italy, and the Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands. It integrates complementary skills in pharmaceutical chemistry and translational cancer research with a special focus on the rational design of new anticancer compounds potentially active on SF3B1 (Splicing Factor 3B …
The economics of platform competition: compatibility, standardization and piracy
2013
This thesis studies the platform competition with compatibility, standardization and piracy. In the first chapter we study the role played by expectations, the strength of the network externality and product differentiation in the strategic decisions of the platforms regarding compatibility and price competition. The decision problem is modeled as a two-stage game. In the first stage platforms simultaneously and non-cooperatively choose the degree of compatibility and in the second stage platforms compete in prices. More specifically, we solve a two-stage game in which duopolists decide simultaneously and non cooperatively the degree of compatibility between their products and they compete …
Evidence of a non-conservative mass transfer in the ultra-compact X-ray source XB 1916-053
2020
The dipping source XB 1916-053 is a compact binary system with an orbital period of 50 min harboring a neutron star. Using ten new {\it Chandra} observations and one {\it Swift/XRT} observation, we are able to extend the baseline of the orbital ephemeris; this allows us to exclude some models that explain the dip arrival times. The Chandra observations provide a good plasma diagnostic of the ionized absorber and allow us to determine whether it is placed at the outer rim of the accretion disk or closer to the compact object. From the available observations we are able to obtain three new dip arrival times extending the baseline of the orbital ephemeris from 37 to 40 years. From the analysis…
Lo stress ossidativo nella steatoepatite alcolica e non alcolica e nella pancreatite acuta e cronica
2010
Using uncertain preferential information from stakeholders to assess the acceptability of alternative forest management plans
2017
In forest management planning, participatory planning processes are often encouraged as a means to acquire relevant information and to enhance the stakeholders' acceptability of alternative plans. This requires the aggregation of the stakeholders' preferences that can be done in a wide variety of manners. The aggregation process strives to reduce the information into a single set of preferences that simplifies the information and allows for the use of discrete decision support tools. Depending on how the preferences are aggregated, a wide range of plan rankings can emerge. Although this range of ranking complicates the issue of plan selection, it does highlight the uncertainty involved in a…
Manifestaciones orales de la infección por VIH en la infancia: artículo de revisión
2004
La gran mayoría de niños con infección por VIH presentan, dentro de sus primeros signos de enfermedad, manifestaciones orales. Estas lesiones orales no están producidas directamente por dicho virus, son manifestaciones asociadas a la infección por VIH, ya que no son patognomónicas de la infección. Algunas de estas lesiones orales tienen un valor pronóstico de cara a la evolución de la infección y la aparición de SIDA, independientemente de otros marcadores de uso más común. Los factores de riesgo esenciales que predisponen al desarrollo de dichas manifestaciones orales son el bajo número de linfocitos T CD4+, xerostomía y la ausencia de tratamiento antiretroviral. Infecciones oportunistas c…