Search results for "SIDE POPULATION"
showing 3 items of 13 documents
Human Endometrial Side Population Cells Exhibit Genotypic, Phenotypic and Functional Features of Somatic Stem Cells
2010
During reproductive life, the human endometrium undergoes around 480 cycles of growth, breakdown and regeneration should pregnancy not be achieved. This outstanding regenerative capacity is the basis for women's cycling and its dysfunction may be involved in the etiology of pathological disorders. Therefore, the human endometrial tissue must rely on a remarkable endometrial somatic stem cells (SSC) population. Here we explore the hypothesis that human endometrial side population (SP) cells correspond to somatic stem cells. We isolated, identified and characterized the SP corresponding to the stromal and epithelial compartments using endometrial SP genes signature, immunophenotyping and char…
Identification of Specific Somatic Stem Cell Markers in the Human Endometrium and Mechanisms of the Bone Marrow for Endometrial Regeneration
2018
INTRODUCTION The endometrium is a unique tissue with a high reconstitution potential during the menstrual cycle throughout the women’s reproductive life. This high regenerative potential seems to be due to the presence of somatic stem cells (SSCs) residing in the endometrial niche inside this tissue. Apart from this endogenous source, an exogenous source of stem cells composed by bone marrow-derived stem cells (BMDSCs) is postulated to exist. The endometrial contribution of bone marrow has been described in healthy and diseased women. Specifically, transplanted BMDSCs release soluble factors under tissue damage that contribute to tissue repair. To be able to differentiate both populations o…